Active Compounds Combination Containing Fluopyram Bacillus and Biologically Control Agent

ABSTRACT

The present invention relates to active compound combinations and compostions for reducing the damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes or phytopathogens and which have fungicidal or nematicidal or insecticidal activity including any combination of the three activities, in particular within a composition, which comprises (A) Fluopyram, (B) a spore-forming bacterium of the genera  Bacillus , selected from  Bacillus firmus, Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillus subtilis  strain GB03,  Bacillus subtilis  strain QST713, and (C) at least one biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, entomopathogenic nematodes, inoculants, botanicals and products produced by microorganisms including proteins or secondary to metabolites. Moreover, the invention relates to a method for curatively or preventively controlling insects, nematodes or phytopathogens on the plant, plant parts, harvested fruits or vegetables, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.

The present invention relates to active compound combinations andcompostions for reducing the damage of plants and plant parts as well aslosses in harvested fruits or vegetables caused by insects, nematodes orphytopathogens and which have fungicidal or nematicidal or insecticidalactivity including any combination of the three activities, inparticular within a composition, which comprises (A) Fluopyram, (B) aspore-forming bacterium of the genera Bacillus, selected from Bacillusfirmus, Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens,Bacillus subtilis strain GB03, Bacillus subtilis strain QST713, and (C)at least one biological control agent, in particular bacteria, fungi oryeasts, protozoa, viruses, entomopathogenic nematodes, inoculants,botanicals and products produced by microorganisms including proteins orsecondary metabolites. Moreover, the invention relates to a method forcuratively or preventively controlling insects, nematodes orphytopathogens on the plant, plant parts, harvested fruits orvegetables, to the use of a combination according to the invention forthe treatment of seed, to a method for protecting a seed and not atleast to the treated seed.

Fluopyram is defined to be the compound of the formula (I)

as well as the N-oxides of the compound thereof.

Fluopyram is a broad spectrum fungicide of the chemical class ofpyridylethylbenzamide derivatives with penetrant and translaminarproperties for foliar, drip, drench and seed treatment applications on awide range of different crops against many economically important plantdiseases. It is very effective in preventative applications againstpowdery mildew species, grey mould and white mould species. It has anefficacy against many other plant diseases. Fluopyram has shown activityin spore germination, germ tube elongation and mycelium growth tests. Atthe biochemical level, fluopyram inhibits mitochondrial respiration byblocking the electron transport in the respiratory chain of SuccinateDehydrogenase (complex II—SDH inhibitor).

Fluopyram and its manufacturing process starting from known andcommercially available compounds is described in EP-A 1 531 673 and WO2004/016088.

A general description of the nematicidal activity ofpyridylethylbenzamide derivatives is found in WO-A 2008/126922. Adescription of nematicidal activity of Bacteria, in particular Bacillusfirmus is found in WO-A 1996/32840, a description of nematicidalactivity of Bacillus chitinosporus is found in WO-A 9821966.

The use of bacteria such as Bacillus sp. as biological control agent insynergistic compositions with fungicides e.g. Fluopyram for controllingphytopathogenic organisms in agriculture is described e.g. in US2011/0110906 A, US 2010/0249193 A, US 20100/209410 A, EP 2460407 A andWO 2012/016989. In these documents only binary mixtures of thebiological control agent and Fluopyram are disclosed. WO 2012/038480 Adiscloses seeds of a plant comprising (a) a gene preferably Axmi031, andAxn2 (producing proteins of Bacillus thuringiensis), (b) a biologicalcontrol agent preferably Bacillus firmus CNCM I-1582, (c) one or moreinsecticides (including biological control agents preferably Pasteuriaand Verticillium and (d) one or more fungicides preferably Fluopyram. Inthis document Pasteuria and Verticillium are not further specified.

Since the environmental and economic requirements imposed on modern-daycrop protection compositions are continually increasing, with regard,for example, to the spectrum of action, toxicity, selectivity,application rate, formation of residues, and favourable preparationability, and since, furthermore, there may be problems, for example,with resistances, a constant task is to develop new compositions, inparticular fungicidal or nematicidal agents, which in some areas atleast help to fulfil the abovementioned requirements. The presentinvention provides active compound combinations/compositions which insome aspects at least achieve the stated objective.

It has now been found, surprisingly, that the combinations according tothe invention not only bring about the additive enhancement of thespectrum of action with respect to the insects, nematodes orphytopathogens to be controlled that was in principle to be expected butachieves a synergistic effect which extends the range of action of thecomponent (A) and of the component (B) and of the component (C) in twoways. Firstly, the rates of application of the component (A) and of thecomponent (B) and of the component (C) are lowered whilst the actionremains equally good. Secondly, the combination still achieves a highdegree of control of insects, nematodes or phytopathogens even where thetwo individual compounds have become totally ineffective in such a lowapplication rate range. This allows, on the one hand, a substantialbroadening of the spectrum of phytopathogenic fungi and nematodes thatcan be controlled and, on the other hand, increased safety in use.

In addition to the fungicidal or nematicidal or insecticidal synergisticactivity, the active compound combinations according to the inventionhave further surprising properties which, in a wider sense, may also becalled synergistic, such as, for example: broadening of the activityspectrum to other insects, nematodes or phytopathogens, for example toresistant strains of plant diseases; lower application rates of theactive compound combination; sufficient control of pests with the aid ofthe active compound combinations according to the invention even atapplication rates where the individual compounds show no or virtually noactivity; advantageous behaviour during formulation or during use, forexample during grinding, sieving, emulsifying, dissolving or dispensing;improved storage stability and light stability; advantageous residueformation; improved toxicological or ecotoxicological behaviour;improved properties of the plant so called plant physiology effects, forexample better growth, increased harvest yields, a better developed rootsystem, a larger leaf area, greener leaves, stronger shoots, less seedrequired, lower phytotoxicity, mobilization of the defence system of theplant, good compatibility with plants. Thus, the use of the activecompound combinations or compositions according to the inventioncontributes considerably to keeping young cereal stands healthy, whichincreases, for example, the winter survival of the cereal seed treated,and also safeguards quality and yield. Moreover, the active compoundcombinations according to the invention may contribute to enhancedsystemic action. Even if the individual compounds of the combinationhave no sufficient systemic properties, the active compound combinationsaccording to the invention may still have this property. In a similarmanner, the active compound combinations according to the invention mayresult in higher long term efficacy of the fungicidal or nematicidal ornematicidal action.

The combinations or compositions according to the present invention arenow described in detail:

Accordingly, the present invention provides an active compoundcombination comprising:

(A) Fluopyram,

(B) a spore-forming bacterium of the genera Bacillus, selected from thegroup consisting of Bacillus firmus, Bacillus cereus, Bacillus pumilis,Bacillus amyloliquefaciens, Bacillus subtilis strain GB03, Bacillussubtilis strain QST713, and

(C) at least one biological control agent selected from the groupconsisting of

(C1) bacteria,

(C2) fungi or yeasts,

(C3) protozoas,

(C4) viruses,

(C5) entomopathogenic nematodes,

(C6) inoculants,

(C7) botanicals, and

(C8) products produced by microorganisms including proteins or secondarymetabolites for reducing overall damage of plants and plant parts aswell as losses in harvested fruits or vegetables caused by insects,nematodes or phytopathogens.

The term active compound combination shall refer to the species as wellas to individual strains of the respective species

Accordingly, the present invention provides particularly an activecompound combination comprising

(A) Fluopyram,

(B) a spore-forming bacterium of the genera Bacillus, selected from thegroup consisting of Bacillus firmus, Bacillus firmus CNCM I-1582,Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillussubtilis strain GB03, Bacillus subtilis strain QST713, and

(C) at least one biological control agent selected from the groupconsisting of

(C1) bacteria,

(C2) fungi or yeasts,

(C3) protozoas,

(C4) viruses,

(C5) entomopathogenic nematodes,

(C6) inoculants,

(C7) botanicals, and (C8.1) Harpin (produced by Erwinia amylovora)

for reducing overall damage of plants and plant parts as well as lossesin harvested fruits or vegetables caused by insects, nematodes orphytopathogens,with the proviso that the spore-forming bacterium (B) of the generaBacillus and the biological control agent (C) are not identical.

Accordingly, the present invention provides particularly an activecompound combination comprising

(A) Fluopyram,

(B) a spore-forming bacterium of the genera Bacillus,

selected from the group consisting of Bacillus firmus, Bacillus firmusCNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillusamyloliquefaciens, Bacillus subtilis strain GB03, Bacillus subtilisstrain QST713, and

(C) one biological control agent selected from the group consisting of

(C1) bacteria,

(C2) fungi or yeasts,

(C3) protozoas,

(C4) viruses,

(C5) entomopathogenic nematodes,

(C6) inoculants,

(C7) botanicals, and (C8.1) Harpin (produced by Erwinia amylovora)

for reducing overall damage of plants and plant parts as well as lossesin harvested fruits or vegetables caused by insects, nematodes orphytopathogens,with the proviso that the spore-forming bacterium (B) of the generaBacillus and the biological control agent (C) are not identical.

The term active compound combination shall refer to the species as wellas to individual strains of the respective species.

In particular, the spore-forming bacterium (B) of the genera Bacillus isselected from the group consisting of

(B1) Bacillus firmus strain CNCM I-1582, in particular the spores (U.S.Pat. No. 6,406,690),

(B2) Bacillus cereus strain CNCM I-1562, in particular the spores, (U.S.Pat. No. 6,406,690),

(B3) Bacillus amyloliquefaciens strain 1N937a,

(B4) Bacillus amyloliquefaciens strain FZB42 (product known asRhizoVital®),

(B5) Bacillus subtilis strain GB03 (marketed as Kodiak™ Gustafson LLC),

(B6) Bacillus subtilis strain QST713 (marketed as Serenade™ byAgraquest),

(B7) Bacillus pumilus strain GB34 (marketed as YieldShield™ by GustafsonLLC),

(B8) Bacillus pumilus strain QST2808 (marketed as Sonata™ by Agraquest).

As used herein “biological control” is defined as control of aphytopathogen or insect or an acarid or a nematode by the use of asecond organism or by the use of botanicals or products produced bymicroorganisms including proteins or secondary metabolites, particularly(C8.1) Harpin. Particularly preferred is the control of nematodes.Particularly preferred “biological control” is defined as control ofnematodes by the use of a second organism or by the use of botanicals orproducts produced by microorganisms including proteins or secondarymetabolites, particularly (C8.1) Harpin.

In the context of the present invention, “control of a phytopathogen orinsect or an acarid or a nematode” means a reduction in infestation byharmful phytopathogens or insect or an acarid or a nematode, comparedwith the untreated plant measured as fungicidal or insecticidal ornematicidal efficacy, preferably a reduction by 25-50%, compared withthe untreated plant (100%), more preferably a reduction by 40-79%,compared with the untreated plant (100%); even more preferably, theinfection by harmful phytopathogens or insect or an acarid or anematode, is entirely suppressed (by 70-100%). The control may becurative, i.e. for treatment of already infected plants, or protective,for protection of plants which have not yet been infected.

Preferably, the compound (A) Fluopyram and the spore-forming bacterium(B) of the genera Bacillus is mixed with one biological control agent(C), in particular bacteria, fungi or yeasts, protozoa, viruses,entomopathogenic nematodes, botanicals or products produced bymicroorganisms including proteins or secondary metabolites, particularly(C8.1) Harpin, for reducing overall damage of plants and plant parts aswell as losses in harvested fruits or vegetables caused by insects,nematodes or phytopathogens.

Mutants of the bacterial, fungal, nematodal or protozoan strains havingall the identifying characteristics of the respective strain shall beincluded within the definition of the biological control agent.

The products produced by microorganisms including proteins or secondarymetabolites, particularly (C8.1) Harpin are characterized that theyexhibit activity against phytopathogenic insects, phytopathogenicnematodes or phytopathogens.

Accordingly, in the present invention the biological control agents (C)comprises bacteria, fungi or yeasts, protozoa, viruses, entomopathogenicnematodes, botanicals and products produced by microorganisms includingproteins or secondary metabolites, particularly (C8.1) Harpin.

Accordingly, in the present invention biological control (C) agentsconsist of bacteria, fungi or yeasts, protozoa, viruses,entomopathogenic nematodes, botanicals and products produced bymicroorganisms including proteins or secondary metabolites, particularly(C8.1) Harpin.

Accordingly, in the present invention biological control agents are inparticular bacteria, fungi or yeasts, protozoa, viruses,entomopathogenic nematodes, botanicals and products produced bymicroorganisms including proteins or secondary metabolites, particularly(C8.1) Harpin.

In particular, the biological control agent (C) is selected from thegroup comprising (C1) bacteria including spore-forming, root-colonizingbacteria, or bacteria useful as biofungicide, bioinsecticide ornematicide selected from the group consisting of

(C1.1) Bacillus agri, (C1.2) Bacillus aizawai, (C1.3) Bacillusalbolactis, (C1.6) Bacillus coagulans, (C1.7) Bacillus endoparasiticus,(C1.8) Bacillus endorhythmos, (C1.9) Bacillus azotoformans, (C1.10)Bacillus kurstaki, (C1.11) Bacillus lacticola, (C1.12) Bacilluslactimorbus, (C1.13) Bacillus lactis, (C1.14) Bacillus laterosporus,(C1.15) Bacillus lentimorbus, (C1.16) Bacillus licheniformis, (C1.17)Bacillus medusa, (C1.18) Bacillus megaterium, (C1.19) Bacillus metiens,(C1.20) Bacillus natto, (C1.21) Bacillus nigrificans, (C1.22) Bacilluspopillae (neu Paenibacillus popilliae), (C1.24) Bacillus siamensis,(C1.25) Bacillus sphaericus (products known as VectoLexs®), (C1.26)Bacillus subtilis var. amyloliquefaciens strain FZB24 (products known asTaegro®), (C1.27) Bacillus thuringiensis, in particular (C1.27a)Bacillus thuringiensis var. israelensis (products known as VectoBac®) or(C1.27b) Bacillus thuringiensis subsp. aizawai strain ABTS-1857(products known as XenTari®), or (C1.27c) Bacillus thuringiensis subsp.kurstaki strain HD-1 (products known as Dipel® ES) or (C1.27d) Bacillusthuringiensis subsp. tenebrionis strain NB 176 (products known asNovodor® FC) or (C1.27e) Bacillus thuringiensis subsp. morrisoni or(C1.27f) Bacillus thuringiensis var san diego, (C1.28) Bacillusuniflagellatus, (C1.29) Delftia acidovorans, in particular strain RAY209(products known as BioBoost®), (C1.30) Lysobacter antibioticus, inparticular strain 13-1 (cf. Biological Control 2008, 45, 288-296),(C1.31) Pasteuria penetrans (synonym Bacillus penetrans), (C1.32)Pseudomonas chlororaphis, in particular strain MA 342 (products known asCedomon), (C1.33) Pseudomonas proradix (products known as Proradix®),(C1.34) Streptomyces galbus, in particular strain K61 (products known asMycostop®, cf. Crop Protection 2006, 25, 468-475), (C1.35) Streptomycesgriseoviridis (products known as Mycostop®), (C1.36) Bacillus lautus,(C1.37) Bacillus atrophaeus, (C1.39) Bacillus mycoides, (C1.40) Bacillusacidoterrestris, (C1.41) Bacillus fastidiosus, (C1.42) Bacillusmegaterium, (C1.43) Bacillus psychrosaccharolyticus, (C1.44) Bacillusmaroccanus, (C1.45) Bacillus megaterium C, (C1.46) Bacilluspantothenticus, (C1.47) Bacillus lentus, (C1.48) Bacillus badius,(C1.49) Bacillus smithi, (C1.50) Acinetobacter spec, (C1.51)Acinetobacter lwoffii, (C1.52) Bacillus luciferensis, (C1.53)Chromobacterium bacterium subtsugae strain PRAA4-1T (product known asGrandevo), (C1.54) Pasteuria usgae (product known as Econem™ BiologicalNematicide), (C1.55) Paenibacillus polymyxa, (C1.56) Bacillus subtilisvar. amyloliquefaciens strain FZB24 (products known as Taegro®), (C1.57)Serratia entomophila (product known as Invade®), (C1.58) Bacilluschitinosporus (C1.59) Pseudomonas cepacia (ex Burkholderia cepacia)strains M54 and J82, (C1.60) Bacillus nematocida, in particular strainB-16;

(C2) fungi or yeasts selected from the group consisting of:

(C2.1) Ampelomyces quisqualis, in particular strain AQ 10 (product knownas AQ 10®), (C2.2) Aureobasidium pullulans, in particular blastosporesof strain DSM14940 or blastospores of strain DSM 14941 or mixturesthereof (product known as Blossom Protect®), (C2.3) Beauveria bassiana,in particular strain ATCC 74040 (products known as Naturalis®, fromIntrachem) and strain GHA (products known as Mycotrol, BotaniGard),(C2.4) Candida oleophila, in particular strain O (products known asNexy®), (C2.5) Coniothyrium minitans, in particular strain CON/M/91-8(products known as Contans®), (C2.6) Dilophosphora alopecuri (productsknown as Twist Fungus®), (C2.7) Gliocladium catenulatum, in particularstrain J1446 (products known as Prestop®), (C2.8) Lecanicillium lecanii(formerly known as Verticillium lecanii), in particular conidia ofstrain KV01 (products known as Mycotal®, Vertalec®), (C2.9) Metarhiziumanisopliae, in particular strain F52 (products known as BIO 1020),(C2.10) Metschnikovia fructicola, in particular the strain NRRL Y-30752(products known as Shemer®), (C2.11) Microsphaeropsis ochracea (productsknown as Microx®), (C2.12) Muscodor albus, in particular strain QST20799 (products known as QRD300), (C2.13) Nomuraea rileyi, in particularstrains SA86101, GU87401, SR86151, CG128 and VA9101, (C2.14)Paecilomyces lilacinus, in particular spores of P. lilacinus strain 251(products known as BioAct®, cf. Crop Protection 2008, 27, 352-361),(C2.15) Paecilomyces fumosoroseus (also known as Isaria fumosorosae,products known as PFR-97TM 20% WDG), (C2.16) Penicillium bilaii, inparticular strain ATCC22348 (products known as JumpStart®, PB-50,Provide), (C2.17) Pichia anomala, in particular strain WRL-076, (C2.18)Pseudozyma flocculosa, in particular strain PF-A22 UL (products known asSporodex® L), (C2.19) Pythium oligandrum DV74 (products known asPolyversum), (C2.20) Trichoderma asperellum, in particular strain ICC012 (products known as Bioten®), (C2.21) Trichoderma harzianum, inparticular T. harzianum T39 (products known as Trichodex®), (C2.22)Beauveria brongniartii (products known as Beaupro), (C2.23) Asohersoniaaleyrodes, (C2.24) Hirsutella thompsoni (products known as Mycohit),(C2.25) Lagenidium giganteum (products known as LAGINEX®), (C2.26)Myrothecium verrucaria strain AARC-0255 (products known as DiTera™),(C2.27) Pandora delphacis, C2.28) Tsukamurella paurometabola (productsknown as HeberNem®), (C2.29) Verticillium lecanii, in particular strainDAOM198499 and DAOM216596, (C2.30) ARF 18 (Arkansas Fungus 18), (C2.31)Trichoderma atroviride (products known as Esquive®) (C2.32) Glomusaggregatum, (C2.33) Glomus etunicatum, (C2.34) Glomus intraradices,(C2.35) Glomus mosseae, (C2.36) Glomus deserticola, (C2.37) Glomusclarum, (C2.38) Glomus brasilianum, (C2.39) Glomus monosporum, (C2.40)Gigaspora margarita, (C2.41) Rhizopogon villosullus, (C2.42) Rhizopogon.luteolus, (C2.43) Rhizopogon. amylopogon, (C2.44) Rhizopogon.fulvigleba, (C2.45) Pisolithus tinctorius, (C2.46) Scleroderma cepa,(C2.47) Scleroderma citrinum, (C2.48) Suillus granulatus, (C2.49)Suillus punctatapies, (C2.50) Laccaria laccata, (C2.51) Laccariabicolor;

(C3) Protozoas selected from the group consisting of

(C3.1) Nosema locustae, (C3.2) Thelohania, (C3.3) Vairimorpha;

(C4) Viruses selected from the group consisting of

(C4.1) Gypsy moth (Lymantria dispar) nuclear polyhedrosis virus (NPV),(C4.2) Tussock moth (Lymantriidae) NPV, (C4.3) Heliothis NPV, (C4.4)Pine sawfly (Neodiprion) NPV, and (C4.5) Codling moth (Cydia pomonella)granulosis virus (GV);), (C4.6) Adoxophyes orana GV (product known asCapex®), (C4.7) Helicoverpa armigera NPV (products known as Vivus Max®,Vivus Gold®) or Gemstar®), (C4.8) Spodoptera exigua NPV, (C4.9)Spodoptera littoralis NPV, (C4.10) Spodoptera litura NPV, (C4.11)Neodiprion abietis NPV (product known as ABIETIV™), (C4.12) Neodiprionsertifer NPV (product known as Neocheck-S™);

(C5) entomopathogenic nematodes selected from the group consisting of

(C5.1) Steinernema ssp. (=Neoaplectana spp.), (C5.2) Steinernemascapterisci, (C5.3) Steinernema feltiae, (C5.4) Steinernema carpocapsae,(C5.5) Heterorhabditis spp., (C5.6) Heterorhabditis heliothidis, (C5.7)Hexamermis spp., (C5.8) Amphimermis spp., (C5.9) Mermis nigrescens,(C5.10) Agamermis decaudata, (C5.11) Maupasina weissi, (C5.12) Subuluraspp., (C5.13) Seuratum cadarachense, (C5.14) Pterygodermatites spp.,(C5.15) Abbreviata caucasica, (C5.16) Spirura guianensis, (C5.17)Diplotriaena spp., (C5.18) Tetrameres spp., (C5.19) Acuaria spp.,(C5.20) Gongylonema spp., (C5.21) Protrellatus spp., (C5.22) Hydromermisspp., (C5.23) Cameronia spp., (C5.24) Physaloptera spp., (C5.25)Chitwoodiella ovofilamenta, (C5.26) Gynopoecilia pseudovipara, (C5.27)Parasitylenchus spp., (C5.28) Neoparasitylenchus rugulosi, (C5.29)Sulphuretylenchus elongatus, (C5.30) Sphaerulariopsis spp., (C5.31)Allantonema spp., (C5.32) Contortylenchus spp., (C5.33) Bovienema spp.,(C5.34) Parasitaphelenchus spp., (C5.35) Parasitorhabditis spp., (C5.36)Phasmarhabditis hermaphrodita, (C5.37) Romanomermis spp., (C5.38)Octomyomermis spp., (C5.39) Strelkovimermis peterseni, (C5.40)Perutilimermis culicis, (C5.41) Culicimermis spp., (C5.42) Empidomermisspp., (C5.43) Gastromermis spp., (C5.44) Isomermis spp., (C5.45)Neomesomermis spp., (C5.46) Limnomermis spp., (C5.47) Mesomermis spp.,and (C5.48) Xenorhabdus luminescence (entomopathogenic bacteriasymbiotically associated with nematodes);

(C6) Inoculants selected from the group consisting of

(C6.1) Rhizobium leguminosarum, (C6.2) Rhizobium tropici, (C6.3)Rhizobium loti, (C6.4) Rhizobium trifolii, (C6.5) Rhizobium meliloti,(C6.6) Rhizobium fredii, (C6.7) Azorhizobium caulinodans, (C6.8)Pseudomonas, (C6.9) Azospirillum, (C6.10) Azotobacter, (C6.11)Streptomyces, (C6.12) Burkholdia, (C6.13) Agrobacterium, (C6.14) EndoMycorhiza, (C6.15) Ecto Mycorhiza, (C6.16) Vesicular Arbuscular (VA)Mycorhiza, (6.17) Bradyrhizobium;

(C7) Botanicals (or: plant extracts) selected from the group consistingof

(C7.1) Thymus oil, (C7.2) Azadirachtin (Neem), (C7.3) Pyrethrum, (C7.4)Cassia nigricans, (C7.5) Quassia amara, (C7.6) Rotenon, (C7.7) Garlic,(C7.8) Quillaja, (C7.9) Sabadilla, in particular Veratrin, (C7.10)Ryania, in particular Ryanodine, (C7.11) Viscum album (mistel), (C7.12)mugwort or common tansy (Tanacetum vulgare), (C7.13) Artemisiaabsinthium, (C7.14) Urtica dioica, (C7.15) Symphytum officinale, (C7.16)Tropaeulum majus, (C7.17) Quercus, (C7.18) mustard flour, (C7.19)Chenopodium anthelminticum, (C7.20) Dryopteris filix-mas, (C7.21) barkof Chinese bittersweet (Celastrus orbiculatus), (C7.22) Equisetumarvense, (C7.23) bark of Celastus angulatus, (C7.24) Laminarin (BrownAlgae), (C7.25) Alginic acid (Brown Algae), (C7.26) Chitin/Chitinosan.(C7.27) Chenopodium quinoa (product known as HeadsUp), (C7.28) Melaleucaalternifolia (products known as Timorex Gold®), (C7.29) Sesame oil(product known as Dragongfire-CCP™);

(C8) Products produced by microorganisms including proteins or secondarymetabolites selected from the group consisting of

(C8.1) Harpin (produced by Erwinia amylovora, products known asHarp-N-Tek™, Messenger®, Employ™ ProAct™), (C8.2) Thymol.

In particular, the biological control agent (C) is selected from thegroup comprising

(C1) bacteria including spore-forming, root-colonizing bacteria, orbacteria useful as biofungicide, bioinsecticide or nematicide selectedfrom the group consisting of

-   -   (C1.1) Bacillus agri, (C1.2) Bacillus aizawai, (C1.3) Bacillus        albolactis, (C1.6) Bacillus coagulans, (C1.7) Bacillus        endoparasiticus, (C1.8) Bacillus endorhythmos, (C1.9) Bacillus        azotoformans, (C1.10) Bacillus kurstaki, (C1.11) Bacillus        lacticola, (C1.12) Bacillus lactimorbus, (C1.13) Bacillus        lactis, (C1.14) Bacillus laterosporus, (C1.15) Bacillus        lentimorbus, (C1.16) Bacillus licheniformis, in particular        strain SB3086 (product known as EcoGuard™ Biofungicide or Green        Releaf from Novozymes Biologicals, US), (C1.17) Bacillus medusa,        (C1.18) Bacillus megaterium, (C1.19) Bacillus metiens, (C1.20)        Bacillus natto, (C1.21) Bacillus nigrificans, (C1.22) Bacillus        popillae (also known as Paenibacillus popilliae, product known        as Milky spore disease from St. Gabriel Laboratories), (C1.24)        Bacillus siamensis, (C1.25) Bacillus sphaericus, in particular        Serotype H5a5b strain 2362, (product known as VectoLex® from        Valent BioSciences, US), (C1.26) Bacillus subtilis var.        amyloliquefaciens strain FZB24 (products known as Taegro®,        Rhizopro, FZB24), (C1.27) Bacillus thuringiensis, in particular        (C1.27a) Bacillus thuringiensis var. israelensis (serotype        H-14), in particular strain AM65-52 (Accession No. ATCC 1276,        products known as VectoBac®, from Valent BioSciences, US) or        strain BMP 144, (product known as Aquabac from Becker Microbial        Products IL), (C1.27b) Bacillus thuringiensis subsp. aizawai        strain ABTS-1857 (products known as XenTari® from Bayer Crop        Science, DE) or strain GC-91 (Accession No. NCTC 11821), or        serotype H-7, (products known as Florbac WG from Valent        BioSciences, US) or (C1.27c) Bacillus thuringiensis subsp.        kurstaki strain HD-1, (products known as Dipel® ES from Valent        BioSciences, US), or strain BMP 123 from Becker Microbial        Products, IL, or strain ABTS 351 (Accession No. ATCC SD-1275),        or strain PB 54 (Accession No. CECT 7209), or strain SA 11        (Accession No. NRRL B30790), or strain SA 12 (Accession No. NRRL        B-30791), or strain EG 2348 (Accession No. NRRL B-18208) or        (C1.27d) Bacillus thuringiensis subsp. tenebrionis strain NB 176        (products known as Novodor® FC from BioFa, DE) or (C1.27e)        Bacillus thuringiensis subsp. morrisoni or (C1.27f) Bacillus        thuringiensis var. san diego (product known as M-One® from        Mycogen Corporation, US) or (C1.27g) Bacillus thuringiensis        subsp. thuringiensis (serotype 1) MPPL002, or (C1.27h) Bacillus        thuringiensis var. aegyptii, or (C1.27k) Bacillus thuringiensis        var. colmeri, or (C1.27l) Bacillus thuringiensis var.        darmstadiensis, or (C1.27m) Bacillus thuringiensis var.        dendrolimus, or (C1.27n) Bacillus thuringiensis var. galleriae,        or (C1.27o) Bacillus thuringiensis var. japonensis, in        particular strain Buibui or (C1.27r) Bacillus thuringiensis var.        7216 (products known as Amactic, Pethian), or (C1.27s) Bacillus        thuringiensis var. T36, or (C1.27t) Bacillus thuringiensis        strain BD#32 (Accession No. NRRL B-21530) from Agraquest, or        (C1.27u) Bacillus thuringiensis strain AQ52 (Accession No. NRRL        B-21619) from Agraquest, or (C1.27v) Bacillus thuringiensis        strain CR-371 (Accession No. ATCC 55273), (C1.28) Bacillus        uniflagellatus, (C1.29) Delftia acidovorans, in particular        strain RAY209 (products known as BioBoost®), (C1.30) Lysobacter        antibioticus, in particular strain 13-1 (cf. Biological Control        2008, 45, 288-296), (C1.31) Pasteuria penetrans (synonym        Bacillus penetrans), (C1.32) Pseudomonas chlororaphis, in        particular strain MA 342 (products known as Cedomon from        Bioagri, S) or strain 63-28 (product known as ATEze from EcoSoil        Systems, US), (C1.33) Pseudomonas proradix (products known as        Proradix®), (C1.34) Streptomyces galbus, in particular strain        K61 (Accession No. DSM 7206, products known as Mycostop®, cf.        Crop Protection 2006, 25, 468-475) or strain NRRL 30232, (C1.35)        Streptomyces griseoviridis (products known as Mycostop®),        (C1.36) Bacillus lautus, (C1.37) Bacillus atrophaeus, (C1.39)        Bacillus mycoides, in particular isolate J (product known as BmJ        from Certis USA) or strain 683 or strain AQ726 (Accession No.        NRRL B21664), (C1.40) Bacillus acidoterrestris, (C1.41) Bacillus        fastidiosus, (C1.42) Bacillus megaterium (products known as        Bioarc®, from BioArc), or strain YFM3.25, (C1.43) Bacillus        psychrosaccharolyticus, (C1.44) Bacillus maroccanus, (C1.45)        Bacillus megaterium C, (C1.46) Bacillus pantothenticus (also        known as Virgibacillus pantothenticus), in particular strain        ATCC 14576/DSM 491, (C1.47) Bacillus lentus, (C1.48) Bacillus        badius, (C1.49) Bacillus smithi, (C1.50) Acinetobacter spec,        (C1.51) Acinetobacter lwoffii, (C1.52) Bacillus luciferensis,        (C1.53) Chromobacterium subtsugae, in particular strain PRAA4-1T        (product known as Grandevo, from Marrone Bio Innovations),        (C1.54) Pasteuria usgae (product known as Econem™ Biological        Nematicide), (C1.55) Paenibacillus polymyxa, in particular        strain AC-1 (product known as Topseed from Green Biotech Company        Ltd.), (C1.57) Serratia entomophila (product known as Invade®),        (C1.58) Bacillus chitinosporus, in particular strain AQ746        (Accession No. NRRL B-21618), (C1.59) Pseudomonas cepacia (ex        Burkholderia cepacia, product known as Deny from Stine Microbial        Products), (C1.60) Bacillus nematocida, in particular strain        B-16, (C1.61) Bacillus circulans, (C1.62) Brevibacillus        laterosporus (also known as Bacillus laterosporus), in        particular strain ATCC 64 or strain NRS 1111 or strain NRS 1645        or strain NRS 1647 or strain BPM3 or strain G4 or strain NCIMB        41419, (C1.63) Corynebacterium paurometabolum, (C1.64)        Lactobacillus acidophilus (products known as Fruitsan® from        Inagrosa-Industrias Agrobiologicas, S.A), (C1.65) Paenibacillus        alvei, in particular strain T36 or strain III3DT-1A or strain        III2E or strain 46C3 or strain 2771, (C1.66) Paenibacillus        macerans, (C1.67) Pasteuria nishizawae, in particular strain        Pn1, (C1.68) Pasteuria ramosa, (C1.69) Pasteuria thornei,        (C1.70) Pseudomonas aeruginosa, in particular strains WS-1 or        PN1, (C1.71) Pseudomonas aureofaciens, in particular strain TX-1        (product known as Spot-Less Biofungicide from Eco Soils Systems,        CA), (C1.72) Pseudomonas fluorescens, in particular strain A506        (products known as Blightban or BlightBan A506 from NuFarm),        (C1.73) Pseudomonas putida, (C1.74) Pseudomonas resinovorans        (products known as Solanacure), (C1.75) Pseudomonas syringae, in        particular strain MA-4 (products known as Biosave from        EcoScience, US), (C1.76) Serratia marcescens, in particular        strain SRM (MTCC8708) or strain R35, (C1.77) Streptomyces        candidus, in particular strain Y21007-2, (products known as        Bio-bac), (C1.78) Streptomyces lydicus, in particular strain        WYCD108 (products known as ActinovateSP) or strain WYEC108        (products known as Actino-iron from Natural Industries), (C1.79)        Streptomyces saraceticus, (C1.80) Streptomyces venezuelae,        (C1.81) Xenorhabdus nematophila, (C1.82) Agrobacterium        radiobacter, (C1.83) Bacillus mojavensis, especially strain        CECT-7666, (C1.84) Pantoea agglomerans, in particular strain        E325 (products known as Bloomtime Biological FD Biopesticide),        (C1.85) Streptomyces colombiensis, (C1.86) Streptomyces sp. WYE        20 (KCTC 0341BP) and WYE 324 (KCTC 0342BP), (C1.87) Bacillus        brevis (also known as Brevibacillus brevis, product known as        Brevisin), in particular strain SS86-3 or strain SS86-4 or        strain SS86-5 or strain 2904, (C1.88) Erwinia carotovora (also        known as Pectobacterium carotovorum) carotovora (product known        as Biokeeper), (C1.89) Xanthomonas campestris pv vesicatoria        (product known as Camprico), (C1.90) Pasteuria reniformis, in        particular strain Pr3, (C1.91) Burkholderia spec strain A396        (Accession No. NRRL B-50319, product known as MBI-206 TGAI from        Marrone Bio Innovations), (C1.92) Bacillus firmus CNCM I-1582,        in particular the spores (cf. U.S. Pat. No. 6,406,690, products        known as Bionem, VOTIVO), (C1.93) Bacillus cereus (synonyms:        Bacillus endorhythmos, Bacillus medusa), in particular spores of        Bacillus cereus strain CNCM I-1562 (cf. U.S. Pat. No.        6,406,690), or strain BP01 (ATCC 55675, product known as        Mepichlor from Arysta, US or Mepplus, Micro-Flo Company LLC,        US), (C1.94) Bacillus amyloliquefaciens strain IN937a or strain        FZB42 (DSM 231179, product known as RhizoVital® from ABiTEP,        DE), or strain B3, or strain D747, (products known as Bacstar®        from Etec Crop Solutions, NZ, or Double Nickel™ from Certis,        US), (C1.95) Bacillus subtilis, in particular strain GB03        (Accession No. ATCC SD-1397, product known as Kodiak® from Bayer        Crop Science, DE) or strain QST713/AQ713 (Accession No. NRRL        B21661, products known as Serenade QST 7130, Serenade Soil and        Serenade Max from AgraQuest, US) or strain AQ 153 (ATCC        accession No. 55614) or strain AQ743 (Accession No. NRRL        B-21665) or strain DB 101, (products known as Shelter from        Dagutat Bio lab, ZA) or strain DB 102, (products known as        Artemis from Dagutat Bio lab, ZA) or strain MBI 600, (products        known as Subtilex from Becker Underwood, US) or strain        QST30002/AQ30002 (Accession No. NRRL B-50421, cf. WO        2012/087980) or strain QST30004/AQ30004 (Accession No. NRRL        B-50455, cf. WO 2012/087980), (C1.96) Bacillus pumilus, in        particular strain GB34 (Accession No. ATCC 700814, products        known as Yield Shield® from Bayer Crop Science, DE) or strain        QST2808 (Accession No. NRRL B-30087, products known as Sonata        QST 2808® from AgraQuest, US), or strain BU F-33 (product known        as Integral F-33 from Becker Underwood, US), or strain AQ717        (Accession No. NRRL B21662, (C1.97) Pasteuria sp., in particular        strain SD-5832 and (C1.98) Pasteuria sp., in particular strain        PTA-9643, (C1.98) Agrobacterium radiobacter, in particular        strain K84 (products known as Galltrol-A from AgBioChem) or        strain K1026 (products known as Nogall, Becker Underwood),        (C1.99) Agrobacterium vitis, in particular the non-pathogenic        strain VAR03-1, (C1.100) Azorhizobium caulinodans, preferably        strain ZB-SK-5, (C1.101) Azospirillum amazonense, (C1.102)        Azospirillum brasilense, (C1.103) Azospirillum halopraeference,        (C1.104) Azospirillum irakense, (C1.105) Azospirillum lipoferum,        (C1.106), Azotobacter chroococcum, preferably strain H 23 (CECT        4435), (C1.107) Azotobacter vinelandii, preferably strain ATCC        12837, (C1.108) Bacillus acidocaldarius, (C1.109) Bacillus        acidoterrestris, (C1.110) Bacillus alcalophilus, (C1.111)        Bacillus alvei, (C1.112) Bacillus aminoglucosidicus, (C1.113)        Bacillus aminovorans, (C1.114) Bacillus amylolyticus (also known        as Paenibacillus amylolyticus), (C1.115) Bacillus        aneurinolyticus, (C1.116) Bacillus subtilis isolate B246, for        example in form of the commercially available product Avogreen        from RE at UP), (C1.117) Bacillus tequilensis, in particular        strain NII-094, (C1.118) Bacillus sp. strain AQ175 (ATCC        Accession No. 55608), (C1.119) Bacillus sp. strain AQ177 (ATCC        Accession No. 55609), (C1.120) Bacillus sp. strain AQ178 (ATCC        Accession No. 53522), (C1.121) Gluconacetobacter diazotrophicus,        (C1.122) Herbaspirilum rubrisubalbicans, (C1.123) Herbaspirilum        seropedicae, (C1.124) Lactobacillus sp. (products known as        Lactoplant from LactoPAFI), (C1.125) Lysobacter enzymogenes, in        particular strain C3 (cf. J Nematol. 2006 June; 38(2): 233-239),        (C1.126) Rhodococcus globerulus strain AQ719 (Accession No. NRRL        B21663, from AgraQuest), (C1.127) Streptomyces sp. Strain NRRL        B-30145 (from Agraquest), (C1.128) Streptomyces acidiscabies, in        particular strain RL-110T, (product known as MBI-005EP from        Marrone Bioinnovations), (C1.129) Streptomyces goshikiensis,        (C1.130) Streptomyces lavendulae, (C1.131) Streptomyces prasinus        (cf. “Prasinons A and B: potent insecticides from Streptomyces        prasinus” Applied microbiology 1973 November), (C1.132)        Streptomyces rimosus;

(C2) fungi or yeasts selected from the group consisting of:

(C2.1) Ampelomyces quisqualis, in particular strain AQ 10 (product knownas AQ 10®), (C2.2) Aureobasidium pullulans, in particular blastosporesof strain DSM14940 or blastospores of strain DSM 14941 or mixturesthereof (product known as Blossom Protect®), (C2.3) Beauveria bassiana,in particular strain ATCC 74040 (products known as Naturalis®) or strainGHA (products known as Mycotrol, BotaniGard) or strain ATP02 (DSM 24665)or strain CG716 (product known as BoveMax), (C2.4) Candida oleophila, inparticular strain O (products known as Nexy®) or strain I-182 (productsknown as ASPIRE®, Decco I-182), (C2.5) Coniothyrium minitans, inparticular strain CON/M/91-8 (DSM-9660) (products known as Contans®),(C2.6) Dilophosphora alopecuri (products known as Twist Fungus®), (C2.7)Gliocladium catenulatum, in particular strain J1446 (products known asPrestop®), (C2.8) Lecanicillium lecanii (formerly known as Verticilliumlecanii), in particular conidia of strain KV01 (products known asMycotal®, Vertalec®, from Koppert/Arysta) or strain DAOM198499 orDAOM216596, (C2.9) Metarhizium anisopliae, in particular strain F52 (DSM3884, ATCC 90448, products known as BIO 1020, MET52) or var. acridumisolate IMI 330189/ARSEF 7486 (products known as Green Muscle®) (C2.10)Metschnikovia fructicola, in particular the strain NRRL Y-30752(products known as Shemer®), (C2.11) Microsphaeropsis ochracea (productsknown as Microx®), (C2.12) Muscodor albus, in particular strain QST20799 (products known as QRD300), (C2.13) Nomuraea rileyi, in particularstrains SA86101, GU87401, SR86151, CG128 and VA9101, (C2.14)Paecilomyces lilacinus, in particular spores of P. lilacinus strain251(AGAL 89/030550) (products known as BioAct®, cf. Crop Protection2008, 27, 352-361), (C2.15) Paecilomyces fumosoroseus (also known asIsaria fumosorosae), in particular strain apopka 97 (ATCC 20874)(products known as PFR-97TM 20% WDG, PreFeRal® WG,), (C2.16) Penicilliumbilaii, in particular strain ATCC22348 (products known as JumpStart®,PB-50, Provide), (C2.17) Pichia anomala, in particular strain WRL-076,(C2.18) Pseudozyma flocculosa, in particular strain PF-A22 UL (productsknown as Sporodex® L), (C2.19) Pythium oligandrum, in particular strainDV74 (products known as Polyversum) or strain M1 (ATCC 38472), (C2.20)Trichoderma asperellum, in particular strain ICC 012 (also known asTrichoderma harzianum ICC012, products known as Bioten®) or strain SKT-1(products known as Triderma® or ECO-HOPE®) or strain T34 (products knownas T34 Biocontrol) or strain SF04 or strain TV1 (also known asTrichoderma viride TV1) or strain T11 (also known as Trichoderma virideT25), (C2.21) Trichoderma harzianum, in particular T. harzianum T39(products known as Trichodex®) or strain T-22 (products known asPLANTSHIELD®T-22G, Rootshield, TurfShield), or strain TH 35 (productsknown as ROOT PRO®) or strain TSTh20/PTA-0317 or strain 1295-22(products known as Bio-Trek), (C2.22) Beauveria brongniartii (productsknown as Beaupro), (C2.23) Aschersonia aleyrodes, (C2.24) Hirsutellathompsoni (products known as Mycohit), (C2.25) Lagenidium giganteum(products known as LAGINEX®), (C2.26) Myrothecium verrucaria strainAARC-0255 (products known as DiTera™), (C2.27) Pandora delphacis,(C2.28) Tsukamurella paurometabola, in particular strain C-924 (productsknown as HeberNem®), (C2.30) ARF 18 (Arkansas Fungus 18), (C2.31)Trichoderma atroviride in particular strain CNCM I-1237 (products knownas Esquive® WP, Sentinel®, Tenet®) or strain NMI No. V08/002387 orstrain NMI No. V08/002389 or strain NMI No. V08/002390 or strain NMI No.V08/002388 (patent application US 2011/0009260) or strain ATCC 20476(IMI 206040) or strain T11 (IMI352941) or strain LC52 (products known asSentinel®, Agrimm Technologies, (products known as Esquive®) or strainNMI V08/002387, or strain NMI V08/002389 or strain SKT-1/FERM P-1651 orstrain SKT-2/FERM P-16511 or strain SKT-3/FERM P-17021 (described inJP3691264) or strain L52 (product known as SENTINEL®), (C2.32) Glomusaggregatum, (C2.33) Glomus etunicatum, (C2.34) Glomus intraradices,(C2.35) Glomus mosseae, (C2.36) Glomus deserticola, (C2.37) Glomusclarum, (C2.38) Glomus brasilianum, (C2.39) Glomus monosporum, (C2.40)Gigaspora margarita, (C2.41) Rhizopogon villosullus, (C2.42) Rhizopogon.luteolus, (C2.43) Rhizopogon. amylopogon, (C2.44) Rhizopogon fulvigleba,(C2.45) Pisolithus tinctorius, (C2.46) Scleroderma cepa, (C2.47)Scleroderma citrinum, (C2.48) Suillus granulatus, (C2.49) Suilluspunctatapies, (C2.50) Laccaria laccata, (C2.51) Laccaria bicolor;(C2.52) Metarhizium flavoviride, (C2.53) Arthrobotrys dactyloides,(C2.54) Arthrobotrys oligospora, (C2.55) Arthrobotrys superba (C2.56)Aspergillus flavus strain NRRL 21882 (product known as Afla-Guard®, fromSyngenta) or strain AF36 (product known as AF36), (C2.57) Candidasaitoana, in particular strain NRRL Y-21022 (products known as BIOCURE®or BIOCOAT®), (C2.58) Chaetomium cupreum, (C2.59) Chaetomium globosum,(C2.60) Chondrostereum purpureum, in particular strain PFC2139, (C2.61)Cladosporium cladosporioides strain H39 (as described in EP2230918 A1),(C2.62) Conidiobolus obscurus, (C2.63) Cryptococcus albidus (productknown as Yield Plus®.), (C2.64) Cryptococcus flavescens, in particularstrain NRRL Y-50378 and strain NRRL Y-50379, (C2.65), Dactylariacandida, (C2.66) Entomophthora virulenta, (C2.67) Harposporiumanguillullae, (C2.68) Hirsutella minnesotensis, (C2.69) Hirsutellarhossiliensis, (C2.70) Meristacrum asterospermum, (C2.71) Microdochiumdimerum, in particular strain L13 (products known as ANTIBOT®,Agrauxine), (C2.72) Monacrosporium cionopagum, (C2.73) Monacrosporiumpsychrophilum, (C2.74) Monacrosporium drechsleri, (C2.75) Monacrosporiumgephyropagum, (C2.76) Ophiostoma piliferum, in particular strain D97(products known as Sylvanex), (C2.77) Paecilomyces variotii, inparticular strain Q-09 (product known as Nemaquim), (C2.78) Pochoniachlamydosporia (=Vercillium chlamydosporiumi), (C2.79) Pseudozymaaphidis, (C2.80) Stagonospora heteroderae, (C2.81) Stagonosporaphaseoli, (C2.82) Talaromyces flavus, in particular strain V117b(products known as PROTUS®), (C2.83) Trichoderma viride (also known asTrichoderma gamsii), in particular strain ICC 080 (products known asREMEDIER® WP, Bioderma®) and strain TV1 (products known as T. virideTV1, Agribiotec), (C2.84) Trichoderma harmatum, isolate 382 (C2.85)Trichoderma koningii, (C2.86) Trichoderma lignorum, (C2.87) Trichodermapolysporum, isolate IMI 206039 (ATCC 20475), (C2.88) Trichodermastromaticum, (C2.89) Trichoderma virens (also known as Gliocladiumvirens), in particular strain GL-21 (products known as SOILGARD®) orstrain G41 (products known as BW240 WP Biological Fungicide), (C2.90)Ulocladium oudemansii, in particular strain HRU3 (products known asBOTRY-ZEN®), (C2.91) Verticillium albo-atrum in particular strainWCS850, (C2.92) Verticillium chlamydosporium, (C2.93) Verticilliumdahlia isolate WCS 850 (products known as Dutch Trig), (2.94) Zoophtoraradicans, (2.95) Cylindrocarpon heteronema, (C2.96) Exophialajeanselmei, (C2.97) Exophilia pisciphila, (C2.98) Fusarium aspergilus,(C2.99) Fusarium oxysporum, for example the non pathogenic strain Fo47(product FUSACLEAN) or the non pathogenic strain 251/2RB (product knownas BIOFOX®), (C2.100) Fusarium solani, for example strain Fs-K (asdescribed in patent application US20110059048), (C2.101) Gliocladiumroseum, in particular strain 321U, (C2.102) Mucor haemelis (productsknown as BIO-AVARD), (C2.103) Nematoctonus geogenius, (C2.104)Nematoctonus leiosporus, (C2.105) Phlebiopsis gigantea (products knownas ROTSOP®), (C2.106) Trichoderma album (products known as Biozeid®),(C2.107) Trichoderma asperellum (products known as BIO-TAM™) and,(C2.108) Trichoderma gamsii (products known as BIO-TAM™) or inparticular strain ICC080 (products known as Bioderma), (C2.109)Hirsutella citriformis, (C2.110) Muscodor roseus strain A3-5 (AccessionNo. NRRL 30548), (C2.111) Neocosmospora vasinfecta, (C2.112) Penicilliumvermiculatum (products known as Vermiculen®), (C2.113) Saccharomycescerevisae, in particular strain CNCM No. I-3936, strain CNCM No. I3937,strain CNCM No. I-3938, strain CNCM No. I-3939 (patent application US2011/0301030), (C2.114) Sporothrix insectorum (products known asSporothrix®),

(C3) Protozoas selected from the group consisting of

(C3.1) Nosema locustae, (C3.2) Thelohania, (C3.3) Vairimorpha;

(C4) Viruses selected from the group consisting of (C4.1) Gypsy moth(Lymantria dispar) nuclear polyhedrosis virus (NPV), (C4.2) Tussock moth(Lymantriidae) NPV, (C4.3) Heliothis NPV, (C4.4) Pine sawfly(Neodiprion) NPV, (C4.5) Codling moth (Cydia pomonella) granulosis virus(GV), (C4.6) Adoxophyes orana GV (product known as Capex®), (C4.7)Helicoverpa armigera NPV (products known as Vivus Max®, Vivus Gold®) orGemstar®), (C4.8) Spodoptera exigua NPV, (C4.9) Spodoptera littoralisNPV, (C4.10) Spodoptera litura NPV, (C4.11) Neodiprion abietis NPV(product known as ABIETIV™), (C4.12) Neodiprion sertifer NPV (productknown as Neocheck-S™), (C4.13) Agrotis segetum (turnip moth) nuclearpolyhedrosis virus (NPV), (C4.14) Anticarsia gemmatalis (Woolly pyrolmoth) mNPV (products known as Polygen), (C4.15) Autographa californica(Alfalfa Looper) mNPV (products known as VPN80 from Agricola El Sol);

(C5) entomopathogenic nematodes selected from the group consisting of

(C5.1) Steinernema ssp. (=Neoaplectana spp.), (C5.2) Steinernemascapterisci, (C5.3) Steinernema feltiae (=Neoplectana carpocapsae,products known as Nemasys®), (C5.4) Steinernema carpocapsae (productsknown as Biocontrol; Nematac® C), (C5.5) Heterorhabditis spp., (C5.6)Heterorhabditis heliothidis, (C5.7) Hexamermis spp., (C5.8) Amphimermisspp., (C5.9) Mermis nigrescens, (C5.10) Agamermis decaudata, (C5.11)Maupasina weissi, (C5.12) Subulura spp., (C5.13) Seuratum cadarachense,(C5.14) Pterygodermatites spp., (C5.15) Abbreviata caucasica, (C5.16)Spirura guianensis, (C5.17) Diplotriaena spp., (C5.18) Tetrameres spp.,(C5.19) Acuaria spp., (C5.20) Gongylonema spp., (C5.21) Protrellatusspp., (C5.22) Hydromermis spp., (C5.23) Cameronia spp., (C5.24)Physaloptera spp., (C5.25) Chitwoodiella ovofilamenta, (C5.26)Gynopoecilia pseudovipara, (C5.27) Parasitylenchus spp., (C5.28)Neoparasitylenchus rugulosi, (C5.29) Sulphuretylenchus elongatus,(C5.30) Sphaerulariopsis spp., (C5.31) Allantonema spp., (C5.32)Contortylenchus spp., (C5.33) Bovienema spp., (C5.34) Parasitaphelenchusspp., (C5.35) Parasitorhabditis spp., (C5.36) Phasmarhabditishermaphrodita, (C5.37) Romanomermis spp., (C5.38) Octomyomermis spp.,(C5.39) Strelkovimermis peterseni, (C5.40) Perutilimermis culicis,(C5.41) Culicimermis spp., (C5.42) Empidomermis spp., (C5.43)Gastromermis spp., (C5.44) Isomermis spp., (C5.45) Neomesomermis spp.,(C5.46) Limnomermis spp., (C5.47) Mesomermis spp., (C5.48) Xenorhabdusluminescence (entomopathogenic bacteria symbiotically associated withnematodes); (C5.49) Heterorhabditis bacteriophora (products known asB-Green, Nemasys® G), (C5.50) Heterorhabditis baujardi, (C5.51)Heterorhabditis indica (products known as Nematon), (C5.52)Heterorhabditis marelatus, (C5.53) Heterorhabditis megidis, (C5.54)Heterorhabditis zealandica, (C5.55) Phasmarhabditis hermaphrodita,(C5.56) Steinernema bibionis, (C5.57) Steinernema glaseri (productsknown as Biotopia), (C5.58) Steinernema kraussei (products known asLarvesure, Nemasys® L), (C5.59) Steinernema riobrave (products known asBiovector), (C5.60) Steinernema scapterisci (products known asNematacS), (C5.61) Steinernema scarabaei, (C5.62) Steinernema siamkayai,(C5.63) Beddingia (=Deladenus) siridicola, (C5.64) Filipjevimermisleipsandra, (C5.65) Steinernema thailandse products known as Nemanox®),

(C6) Inoculants selected from the group consisting of

(C6.1) Rhizobium leguminosarum, in particular bv. viceae strain Z25(Accession No. CECT 4585), (C6.2) Rhizobium tropici, (C6.3) Rhizobiumloci, (C6.4) Rhizobium trifolii, (C6.5) Rhizobium meliloti, (C6.6)Rhizobium fredii, (C6.7) Azorhizobium caulinodans, (C6.8) Pseudomonas,(C6.9) Azospirillum, (C6.10) Azotobacter, (C6.11) Streptomyces, (C6.12)Burkholdia, (C6.13) Agrobacterium, (C6.14) Endo Mycorhiza, (C6.15) EctoMycorhiza, (C6.16) Vesicular Arbuscular (VA) Mycorhiza, (C6.17)Bradyrhizobium;

(C7) Botanicals (or: plant extracts) selected from the group consistingof

(C7.1) Thymus oil, (C7.2) Azadirachtin (Neem), (C7.3) Pyrethrum, (C7.4)Cassia nigricans, (C7.5) Quassia amara, (C7.6) Rotenon, (C7.7) Garlic,(C7.8) Quillaja, (C7.9) Sabadilla, in particular Veratrin, (C7.10)Ryania, in particular Ryanodine, (C7.11) Viscum album (mistel), (C7.12)mugwort or common tansy (Tanacetum vulgare), (C7.13) Artemisiaabsinthium, (C7.14) Urtica dioica, (C7.15) Symphytum officinale, (C7.16)Tropaeulum majus, (C7.17) Quercus (C7.18) mustard flour, (C7.19)Chenopodium anthelminticum, (C7.20) Dryopteris filix-mas, (C7.21) barkof Chinese bittersweet (Celastrus orbiculatus), (C7.22) Equisetumarvense, (C7.23) bark of Celastus angulatus, (C7.24) Laminarin (BrownAlgae), (C7.25) Alginic acid (Brown Algae), (C7.26) Chitin/Chitinosan.(C7.27) Chenopodium quinoa (product known as HeadsUp), (C7.28) Melaleucaalternifolia (products known as Timorex Gold®), (C7.29) Sesame oil(product known as Dragongfire-CCP™) and (C7.30) natural extracts orsimulated blend of Chenopodium ambrosioides (products known as Requiem).

(C8) Products produced by microorganisms including proteins or secondarymetabolites selected from the group consisting of

(C8.1) Harpin (produced by Erwinia amylovora, products known asHarp-N-Tek™, Messenger®, Employ™ PrOACt™).

Bacillus subtilis, for example the strains GBO3 and QST 713, as well asBacillus amyloliquefaciens, strain FZB 24 and 42, are species withphytopathogenic properties. These bacteria are applied to the soil or tothe leaves. Bacillus thuringiensis with its different subspeciesproduces endotoxin containing crystals which have high insect pathogenicspecifity. Bacillus thuringiensis subsp. kurstaki, strain HD-1, is usedfor control of lepidopteran larvae, but without noctuidae. Bacillusthuringiensis subsp. aizawai, for example the strains SAN 401 I,ABG-6305 and ABG-6346, is effective against different lepidopteranspecies including also noctuidae. Bacillus thuringiensis subsp.tenebrionis, for example the strains SAN 418 I and ABG6479, protectsplants against leaf beetle larvae. Bacillus thuringiensis subsp.israelensis, for example the strains SAN 402 I and ABG-6164, is appliedagainst larvae of various dipteran pests, e.g. mosquitoes andnematoceres.

Preference is given to combinations comprising at least

(A) Fluopyram and (B1) Bacillus firmus strain CNCM I-1582 and (C) thebiological control agent, with the proviso that the spore-formingbacterium (B) of the genera Bacillus and the biological control agent(C) are not identical.

Preference is given to combinations comprising at least

(A) Fluopyram and (B2) Bacillus cereus strain CNCM I-1562 and (C) thebiological control agent, with the proviso that the spore-formingbacterium (B) of the genera Bacillus and the biological control agent(C) are not identical.

Preference is given to combinations comprising at least

(A) Fluopyram and (B3) Bacillus amyloliquefaciens strain IN937a, and (C)the biological control agent, with the proviso that the spore-formingbacterium (B) of the genera Bacillus and the biological control agent(C) are not identical.

Preference is given to combinations comprising at least

(A) Fluopyram and (B4) Bacillus amyloliquefaciens strain FZB42 and (C)the biological control agent, with the proviso that the spore-formingbacterium (B) of the genera Bacillus and the biological control agent(C) are not identical.

Preference is given to combinations comprising at least

(A) Fluopyram and (B5) Bacillus subtilis strain GB03 and (C) thebiological control agent, with the proviso that the spore-formingbacterium (B) of the genera Bacillus and the biological control agent(C) are not identical.

Preference is given to combinations comprising at least

(A) Fluopyram and (B6) Bacillus subtilis strain QST713 and (C) thebiological control agent, with the proviso that the spore-formingbacterium (B) of the genera Bacillus and the biological control agent(C) are not identical.

Preference is given to combinations comprising at least

(A) Fluopyram and (B7) Bacillus pumilus strain GB34 and (C) thebiological control agent, with the proviso that the spore-formingbacterium (B) of the genera Bacillus and the biological control agent(C) are not identical.

Preference is given to combinations comprising at least

-   (A) Fluopyram and (B8) Bacillus pumilus strain QST2808 and (C) the    biological control agent, with the proviso that the spore-forming    bacterium (B) of the genera Bacillus and the biological control    agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and (B1)Bacillus firmus strain CNCM I1582 and (C) the biological control agent,with the proviso that the spore-forming bacterium (B) of the generaBacillus and the biological control agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and (B2)Bacillus cereus strain CNCM I1562 and (C) the biological control agent,with the proviso that the spore-forming bacterium (B) of the generaBacillus and the biological control agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and (B3)Bacillus amyloliquefaciens strain 1N937a, and (C) the biological controlagent, with the proviso that the spore-forming bacterium (B) of thegenera Bacillus and the biological control agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and (B4)Bacillus amyloliquefaciens strain FZB42 and (C) the biological controlagent, with the proviso that the spore-forming bacterium (B) of thegenera Bacillus and the biological control agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and (B5)Bacillus subtilis strain GB03 and (C) the biological control agent, withthe proviso that the spore-forming bacterium (B) of the genera Bacillusand the biological control agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and (B6)Bacillus subtilis strain QST713 and (C) the biological control agent,with the proviso that the spore-forming bacterium (B) of the generaBacillus and the biological control agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and (B7)Bacillus pumilus strain GB34 and (C) the biological control agent, withthe proviso that the spore-forming bacterium (B) of the genera Bacillusand the biological control agent (C) are not identical.

Preference is given to combinations comprising Fluopyram and (B8)Bacillus pumilus strain QST2808 and (C) the biological control agent,with the proviso that the spore-forming bacterium (B) of the generaBacillus and the biological control agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and the(B1) Bacillus firmus strain CNCM I1582 and one biological control agentselected from group (C1) bacteria as described above with the provisothat the spore-forming bacterium (B) of the genera Bacillus and thebiological control agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and the(B2) Bacillus cereus strain CNCM I1562 and one biological control agentselected from (C1) bacteria as described above with the proviso that thespore-forming bacterium (B) of the genera Bacillus and the biologicalcontrol agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and the(B3) Bacillus amyloliquefaciens strain 1N937a, and one biologicalcontrol agent selected from (C1) bacteria as described above, with theproviso that the spore-forming bacterium (B) of the genera Bacillus andthe biological control agent (C) are not identical with the proviso thatthe spore-forming bacterium (B) of the genera Bacillus and thebiological control agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and the(B4) Bacillus amyloliquefaciens strain FZB42 and one biological controlagent selected from (C1) bacteria as described above, with the provisothat the spore-forming bacterium (B) of the genera Bacillus and thebiological control agent (C) are not identical with the proviso that thespore-forming bacterium (B) of the genera Bacillus and the biologicalcontrol agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and the(B5) Bacillus subtilis strain GB03 and one biological control agentselected from (C1) bacteria as described above, with the proviso thatthe spore-forming bacterium (B) of the genera Bacillus and thebiological control agent (C) are not identical with the proviso that thespore-forming bacterium (B) of the genera Bacillus and the biologicalcontrol agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and the(B6) Bacillus subtilis strain QST713 and one biological control agentselected from (C1) bacteria as described above, with the proviso thatthe spore-forming bacterium (B) of the genera Bacillus and thebiological control agent (C) are not identical.

Preference is given to combinations comprising (A) Fluopyram and the(B7) Bacillus pumilus strain GB34 and one biological control agentselected from (C1) bacteria as described above, with the proviso thatthe spore-forming bacterium (B) of the genera Bacillus and thebiological control agent (C) are not identical.

Preference is given to combinations comprising Fluopyram and the (B8)Bacillus pumilus strain QST2808 and one biological control agentselected from (C1) bacteria as described above, with the proviso thatthe spore-forming bacterium (B) of the genera Bacillus and thebiological control agent (C) are not identical.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B1) Bacillus firmus strain CNCM I-1582 and onebiological control agent selected from (C2) fungi or yeasts as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B2) Bacillus cereus strain CNCM I-1562 and onebiological control agent selected from (C2) fungi or yeasts as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B3) Bacillus amyloliquefaciens strain IN937a, andone biological control agent selected from (C2) fungi or yeasts asdescribed above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B4) Bacillus amyloliquefaciens strain FZB42 andone biological control agent selected from (C2) fungi or yeasts asdescribed above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B5) Bacillus subtilis strain GB03 and onebiological control agent selected from (C2) fungi or yeasts as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B6) Bacillus subtilis strain QST713 and onebiological control agent selected from (C2) fungi or yeasts as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B7) Bacillus pumilus strain GB34 and onebiological control agent selected from (C2) fungi or yeasts as describedabove.

Preference is given to combinations comprising at least

-   (A) Fluopyram and the (B8) Bacillus pumilus strain QST2808 and one    biological control agent selected from (C2) fungi or yeasts as    described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B1) Bacillus firmus strain CNCM I-1582 and onebiological control agent selected from (C3) protozoas as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B2) Bacillus cereus strain CNCM I-1562 and onebiological control agent selected from (C3) protozoas as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B3) Bacillus amyloliquefaciens strain IN937a, andone biological control agent selected from (C3) protozoas as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B4) Bacillus amyloliquefaciens strain FZB42 andone biological control agent selected from (C3) protozoas as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B5) Bacillus subtilis strain GB03 and onebiological control agent selected from (C3) protozoas as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B6) Bacillus subtilis strain QST713 and onebiological control agent selected from (C3) protozoas as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B7) Bacillus pumilus strain GB34 and onebiological control agent selected from (C3) protozoas as describedabove.

Preference is given to combinations comprising at least

-   -   (A) Fluopyram and the (B8) Bacillus pumilus strain QST2808 and        one biological control agent selected from (C3) protozoas as        described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B1) Bacillus firmus strain CNCM I-1582 and onebiological control agent selected from (C4) viruses as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B2) Bacillus cereus strain CNCM I-1562 and onebiological control agent selected from (C4) viruses as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B3) Bacillus amyloliquefaciens strain IN937a, andone biological control agent selected from (C4) viruses as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B4) Bacillus amyloliquefaciens strain FZB42 andone biological control agent selected from (C4) viruses as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B5) Bacillus subtilis strain GB03 and onebiological control agent selected from (C4) viruses as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B6) Bacillus subtilis strain QST713 and onebiological control agent selected from (C4) viruses as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B7) Bacillus pumilus strain GB34 and onebiological control agent selected from (C4) viruses as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B8) Bacillus pumilus strain QST2808 and onebiological control agent selected from (C4) viruses as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B1) Bacillus firmus strain CNCM I-1582 and onebiological control agent selected from (C5) entomopathogenic nematodesas described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B2) Bacillus cereus strain CNCM I-1562 and onebiological control agent selected from (C5) entomopathogenic nematodesas described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B3) Bacillus amyloliquefaciens strain IN937a, andone biological control agent selected from (C5) entomopathogenicnematodes as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B4) Bacillus amyloliquefaciens strain FZB42 andone biological control agent selected from (C5) entomopathogenicnematodes as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B5) Bacillus subtilis strain GB03 and onebiological control agent selected from (C5) entomopathogenic nematodesas described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B6) Bacillus subtilis strain QST713 and onebiological control agent selected from (C5) entomopathogenic nematodesas described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B7) Bacillus pumilus strain GB34 and onebiological control agent selected from (C5) entomopathogenic nematodesas described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B8) Bacillus pumilus strain QST2808 and onebiological control agent selected from (C5) entomopathogenic nematodesas described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B1) Bacillus firmus strain CNCM I-1582 and onebiological control agent selected from (C6) inoculants as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B2) Bacillus cereus strain CNCM I-1562 and onebiological control agent selected from (C6) inoculants as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B3) Bacillus amyloliquefaciens strain IN937a, andone biological control agent selected from (C6) inoculants as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B4) Bacillus amyloliquefaciens strain FZB42 andone biological control agent selected from (C6) inoculants as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B5) Bacillus subtilis strain GB03 and onebiological control agent selected from (C6) inoculants as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B6) Bacillus subtilis strain QST713 and onebiological control agent selected from (C6) inoculants as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B7) Bacillus pumilus strain GB34 and onebiological control agent selected from

(C6) inoculants as described above.

Preference is given to combinations comprising at least

-   -   (A) Fluopyram and the (B8) Bacillus pumilus strain QST2808 and        one biological control agent selected from (C6) inoculants as        described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B1) Bacillus firmus strain CNCM I-1582 and onebiological control agent selected from (C7) botanicals as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B2) Bacillus cereus strain CNCM I-1562 and onebiological control agent selected from (C7) botanicals as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B3) Bacillus amyloliquefaciens strain IN937a, andone biological control agent selected from (C7) botanicals as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B4) Bacillus amyloliquefaciens strain FZB42 andone biological control agent selected from (C7) botanicals as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B5) Bacillus subtilis strain GB03 and onebiological control agent selected from (C7) botanicals as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B6) Bacillus subtilis strain QST713 and onebiological control agent selected from (C7) botanicals as describedabove.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B7) Bacillus pumilus strain GB34 and onebiological control agent selected from

(C7) botanicals as described above.

Preference is given to combinations comprising at least

-   -   (A) Fluopyram and the (B8) Bacillus pumilus strain QST2808 and        one biological control agent selected from (C7) botanicals as        described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B1) Bacillus firmus strain CNCM I-1582 and onebiological control agent selected from (C8.1) Harpin (produced byErwinia amylovora) as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B2) Bacillus cereus strain CNCM I-1562 and onebiological control agent selected from (C8.1) Harpin (produced byErwinia amylovora) as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B3) Bacillus amyloliquefaciens strain 1N937a, andone biological control agent selected from (C8.1) Harpin (produced byErwinia amylovora) as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B4) Bacillus amyloliquefaciens strain FZB42 andone biological control agent selected from (C8.1) Harpin (produced byErwinia amylovora) as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B5) Bacillus subtilis strain GB03 and onebiological control agent selected from (C8.1) Harpin (produced byErwinia amylovora) as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B6) Bacillus subtilis strain QST713 and onebiological control agent selected from (C8.1) Harpin (produced byErwinia amylovora) as described above.

Preference is given to combinations comprising at least

(A) Fluopyram and the (B7) Bacillus pumilus strain GB34 and onebiological control agent selected from (C8.1) Harpin (produced byErwinia amylovora) as described above.

Preference is given to combinations comprising at least

-   -   (A) Fluopyram and the (B8) Bacillus pumilus strain QST2808 and        one biological control agent selected from (C8.1) Harpin        (produced by Erwinia amylovora) as described above.

(C5) entomopathogenic nematodes,

(C6) inoculants,

(C7) botanicals, and (C8.1) Harpin (produced by Erwinia amylovora)

Preference is also given to the following ternary active compoundcombinations selected from the group (G1) consisting of

(A)+(B1)+(C1.1), (A)+(B1)+(C1.2), (A)+(B1)+(C1.3), (A)+(B1)+(C1.4),(A)+(B1)+(C1.5), (A)+(B1)+(C1.6), (A)+(B1)+(C1.7), (A)+(B1)+(C1.8),(A)+(B1)+(C1.9), (A)+(B1)+(C1.10), (A)+(B1)+(C1.11), (A)+(B1)+(C1.12),(A)+(B1)+(C1.13), (A)+(B1)+(C1.14), (A)+(B1)+(C1.15), (A)+(B1)+(C1.16),(A)+(B1)+(C1.17), (A)+(B1)+(C1.18), (A)+(B1)+(C1.19), (A)+(B1)+(C1.20),(A)+(B1)+(C1.21), (A)+(B1)+(C1.22), (A)+(B1)+(C1.23), (A)+(B1)+(C1.24),(A)+(B1)+(C1.25), (A)+(B1)+(C1.26), (A)+(B1)+(C1.27), (A)+(B1)+(C1.27a),(A)+(B1)+(C1.27b), (A)+(B1)+(C1.27c), (A)+(B1)+(C1.27d),(A)+(B1)+(C1.27e), (A)+(B1)+(C1.27f), (A)+(B1)+(C1.27g),(A)+(B1)+(C1.27h), (A)+(B1)+(C1.27), (A)+(B1)+(C1.27l),(A)+(B1)+(C1.27m), (A)+(B1)+(C1.27n), (A)+(B1)+(C1.27o),(A)+(B1)+(C1.27r), (A)+(B1)+(C1.27s), (A)+(B1)+(C1.27t),(A)+(B1)+(C1.27u), (A)+(B1)+(C1.27v), (A)+(B1)+(C1.28),(A)+(B1)+(C1.29), (A)+(B1)+(C1.30), (A)+(B1)+(C1.31), (A)+(B1)+(C1.32),(A)+(B1)+(C1.33), (A)+(B1)+(C1.34), (A)+(B1)+(C1.35), (A)+(B1)+(C1.36),(A)+(B1)+(C1.37), (A)+(B1)+(C1.38), (A)+(B1)+(C1.39), (A)+(B1)+(C1.40),(A)+(B1)+(C1.41), (A)+(B1)+(C1.42), (A)+(B1)+(C1.43), (A)+(B1)+(C1.44),(A)+(B1)+(C1.45), (A)+(B1)+(C1.46), (A)+(B1)+(C1.47), (A)+(B1)+(C1.48),(A)+(B1)+(C1.49), (A)+(B1)+(C1.50), (A)+(B1)+(C1.51), (A)+(B1)+(C1.52),(A)+(B1)+(C1.53), (A)+(B1)+(C1.54), (A)+(B1)+(C1.55), (A)+(B1)+(C1.56),(A)+(B1)+(C1.57), (A)+(B1)+(C1.58), (A)+(B1)+(C1.59), (A)+(B1)+(C1.60),(A)+(B1)+(C1.61), (A)+(B1)+(C1.62), (A)+(B1)+(C1.63), (A)+(B1)+(C1.64),(A)+(B1)+(C1.65), (A)+(B1)+(C1.66), (A)+(B1)+(C1.67), (A)+(B1)+(C1.68),(A)+(B1)+(C1.69), (A)+(B1)+(C1.70), (A)+(B1)+(C1.71), (A)+(B1)+(C1.72),(A)+(B1)+(C1.73), (A)+(B1)+(C1.74), (A)+(B1)+(C1.75), (A)+(B1)+(C1.76),(A)+(B1)+(C1.77), (A)+(B1)+(C1.78), (A)+(B1)+(C1.79), (A)+(B1)+(C1.80),(A)+(B1)+(C1.81), (A)+(B1)+(C1.82), (A)+(B1)+(C1.83), (A)+(B1)+(C1.84),(A)+(B1)+(C1.85), (A)+(B1)+(C1.86), (A)+(B1)+(C1.87), (A)+(B1)+(C1.88),(A)+(B1)+(C1.89), (A)+(B1)+(C1.90), (A)+(B1)+(C1.91), (A)+(B1)+(C1.92),(A)+(B1)+(C1.93), (A)+(B1)+(C1.94), (A)+(B1)+(C1.95), (A)+(B1)+(C1.96),(A)+(B1)+(C1.97), (A)+(B1)+(C1.98), (A)+(B1)+(C1.99), (A)+(B1)+(C1.100),(A)+(B1)+(C1.101), (A)+(B1)+(C1.102), (A)+(B1)+(C1.103),(A)+(B1)+(C1.104), (A)+(B1)+(C1.105), (A)+(B1)+(C1.106),(A)+(B1)+(C1.107), (A)+(B1)+(C1.108), (A)+(B1)+(C1.109),(A)+(B1)+(C1.110), (A)+(B1)+(C1.111), (A)+(B1)+(C1.112),(A)+(B1)+(C1.113), (A)+(B1)+(C1.114), (A)+(B1)+(C1.115),(A)+(B1)+(C1.116), (A)+(B1)+(C1.117), (A)+(B1)+(C1.118),(A)+(B1)+(C1.119), (A)+(B1)+(C1.120), (A)+(B1)+(C1.121),(A)+(B1)+(C1.122), (A)+(B1)+(C1.123), (A)+(B1)+(C1.124),(A)+(B1)+(C1.125), (A)+(B1)+(C1.126), (A)+(B1)+(C1.127),(A)+(B1)+(C1.128), (A)+(B1)+(C1.129), (A)+(B1)+(C1.130),(A)+(B1)+(C1.131), (A)+(B1)+(C1.132), (A)+(B1)+(C2.1), (A)+(B1)+(C2.2),(A)+(B1)+(C2.3), (A)+(B1)+(C2.4), (A)+(B1)+(C2.5), (A)+(B1)+(C2.6),(A)+(B1)+(C2.7), (A)+(B1)+(C2.8), (A)+(B1)+(C2.9), (A)+(B1)+(C2.10),(A)+(B1)+(C2.11), (A)+(B1)+(C2.12), (A)+(B1)+(C2.13), (A)+(B1)+(C2.14),(A)+(B1)+(C2.15), (A)+(B1)+(C2.16), (A)+(B1)+(C2.17), (A)+(B1)+(C2.18),(A)+(B1)+(C2.19), (A)+(B1)+(C2.20), (A)+(B1)+(C2.21), (A)+(B1)+(C2.22),(A)+(B1)+(C2.23), (A)+(B1)+(C2.24), (A)+(B1)+(C2.25), (A)+(B1)+(C2.26),(A)+(B1)+(C2.27), (A)+(B1)+(C2.28), (A)+(B1)+(C2.29), (A)+(B1)+(C2.30),(A)+(B1)+(C2.31), (A)+(B1)+(C2.32), (A)+(B1)+(C2.33), (A)+(B1)+(C2.34),(A)+(B1)+(C2.35), (A)+(B1)+(C2.36), (A)+(B1)+(C2.37), (A)+(B1)+(C2.38),(A)+(B1)+(C2.39), (A)+(B1)+(C2.40), (A)+(B1)+(C2.41), (A)+(B1)+(C2.42),(A)+(B1)+(C2.43), (A)+(B1)+(C2.44), (A)+(B1)+(C2.45), (A)+(B1)+(C2.46),(A)+(B1)+(C2.47), (A)+(B1)+(C2.48), (A)+(B1)+(C2.49), (A)+(B1)+(C2.50),(A)+(B1)+(C2.51), (A)+(B1)+(C2.52), (A)+(B1)+(C2.53), (A)+(B1)+(C2.54),(A)+(B1)+(C2.55), (A)+(B1)+(C2.56), (A)+(B1)+(C2.57), (A)+(B1)+(C2.58),(A)+(B1)+(C2.59), (A)+(B1)+(C2.60), (A)+(B1)+(C2.61), (A)+(B1)+(C2.62),(A)+(B1)+(C2.63), (A)+(B1)+(C2.64), (A)+(B1)+(C2.65), (A)+(B1)+(C2.66),(A)+(B1)+(C2.67), (A)+(B1)+(C2.68), (A)+(B1)+(C2.69), (A)+(B1)+(C2.70),(A)+(B1)+(C2.71), (A)+(B1)+(C2.72), (A)+(B1)+(C2.73), (A)+(B1)+(C2.74),(A)+(B1)+(C2.75), (A)+(B1)+(C2.76), (A)+(B1)+(C2.77), (A)+(B1)+(C2.78),(A)+(B1)+(C2.79), (A)+(B1)+(C2.80), (A)+(B1)+(C2.81), (A)+(B1)+(C2.82),(A)+(B1)+(C2.83), (A)+(B1)+(C2.84), (A)+(B1)+(C2.85), (A)+(B1)+(C2.86),(A)+(B1)+(C2.87), (A)+(B1)+(C2.88), (A)+(B1)+(C2.89), (A)+(B1)+(C2.90),(A)+(B1)+(C2.91), (A)+(B1)+(C2.92), (A)+(B1)+(C2.93), (A)+(B1)+(C2.94),(A)+(B1)+(C2.95), (A)+(B1)+(C2.96), (A)+(B1)+(C2.97), (A)+(B1)+(C2.98),(A)+(B1)+(C2.99), (A)+(B1)+(C2.100), (A)+(B1)+(C2.101),(A)+(B1)+(C2.102), (A)+(B1)+(C2.103), (A)+(B1)+(C2.104),(A)+(B1)+(C2.105), (A)+(B1)+(C2.106), (A)+(B1)+(C2.107),(A)+(B1)+(C2.108), (A)+(B1)+(C2.109), (A)+(B1)+(C2.110),(A)+(B1)+(C2.111), (A)+(B1)+(C2.112), (A)+(B1)+(C2.113),(A)+(B1)+(C2.114), (A)+(B1)+(C3.1), (A)+(B1)+(C3.2), (A)+(B1)+(C3.3),(A)+(B1)+(C4.1), (A)+(B1)+(C4.2), (A)+(B1)+(C4.3), (A)+(B1)+(C4.4),(A)+(B1)+(C4.5), (A)+(B1)+(C4.6), (A)+(B1)+(C4.7), (A)+(B1)+(C4.8),(A)+(B1)+(C4.9), (A)+(B1)+(C4.10), (A)+(B1)+(C4.11), (A)+(B1)+(C4.12),(A)+(B1)+(C4.13), (A)+(B1)+(C4.14), (A)+(B1)+(C4.15), (A)+(B1)+(C5.1),(A)+(B1)+(C5.2), (A)+(B1)+(C5.3), (A)+(B1)+(C5.4), (A)+(B1)+(C5.5),(A)+(B1)+(C5.6), (A)+(B1)+(C5.7), (A)+(B1)+(C5.8), (A)+(B1)+(C5.9),(A)+(B1)+(C5.10), (A)+(B1)+(C5.11), (A)+(B1)+(C5.12), (A)+(B1)+(C5.13),(A)+(B1)+(C5.14), (A)+(B1)+(C5.15), (A)+(B1)+(C5.16), (A)+(B1)+(C5.17),(A)+(B1)+(C5.18), (A)+(B1)+(C5.19), (A)+(B1)+(C5.20), (A)+(B1)+(C5.21),(A)+(B1)+(C5.22), (A)+(B1)+(C5.23), (A)+(B1)+(C5.24), (A)+(B1)+(C5.25),(A)+(B1)+(C5.26), (A)+(B1)+(C5.27), (A)+(B1)+(C5.28), (A)+(B1)+(C5.29),(A)+(B1)+(C5.30), (A)+(B1)+(C5.31), (A)+(B1)+(C5.32), (A)+(B1)+(C5.33),(A)+(B1)+(C5.34), (A)+(B1)+(C5.35), (A)+(B1)+(C5.36), (A)+(B1)+(C5.37),(A)+(B1)+(C5.38), (A)+(B1)+(C5.39), (A)+(B1)+(C5.40), (A)+(B1)+(C5.41),(A)+(B1)+(C5.42), (A)+(B1)+(C5.43), (A)+(B1)+(C5.44), (A)+(B1)+(C5.45),(A)+(B1)+(C5.46), (A)+(B1)+(C5.47), (A)+(B1)+(C5.48), (A)+(B1)+(C5.49),(A)+(B1)+(C5.50), (A)+(B1)+(C5.51), (A)+(B1)+(C5.52), (A)+(B1)+(C5.53),(A)+(B1)+(C5.54), (A)+(B1)+(C5.55), (A)+(B1)+(C5.56), (A)+(B1)+(C5.57),(A)+(B1)+(C5.58), (A)+(B1)+(C5.59), (A)+(B1)+(C5.60), (A)+(B1)+(C5.61),(A)+(B1)+(C5.62), (A)+(B1)+(C5.63), (A)+(B1)+(C5.64), (A)+(B1)+(C5.65),(A)+(B1)+(C6.1), (A)+(B1)+(C6.2), (A)+(B1)+(C6.3), (A)+(B1)+(C6.4),(A)+(B1)+(C6.5), (A)+(B1)+(C6.6), (A)+(B1)+(C6.7), (A)+(B1)+(C6.8),(A)+(B1)+(C6.9), (A)+(B1)+(C6.10), (A)+(B1)+(C6.11), (A)+(B1)+(C6.12),(A)+(B1)+(C6.13), (A)+(B1)+(C6.14), (A)+(B1)+(C6.15), (A)+(B1)+(C6.16),(A)+(B1)+(C6.17), (A)+(B1)+(C7.1), (A)+(B1)+(C7.2), (A)+(B1)+(C7.3),(A)+(B1)+(C7.4), (A)+(B1)+(C7.5), (A)+(B1)+(C7.6), (A)+(B1)+(C7.7),(A)+(B1)+(C7.8), (A)+(B1)+(C7.9), (A)+(B1)+(C7.10), (A)+(B1)+(C7.11),(A)+(B1)+(C7.12), (A)+(B1)+(C7.13), (A)+(B1)+(C7.14), (A)+(B1)+(C7.15),(A)+(B1)+(C7.16), (A)+(B1)+(C7.17), (A)+(B1)+(C7.18), (A)+(B1)+(C7.19),(A)+(B1)+(C7.20), (A)+(B1)+(C7.21), (A)+(B1)+(C7.22), (A)+(B1)+(C7.23),(A)+(B1)+(C7.24), (A)+(B1)+(C7.25), (A)+(B1)+(C7.26), (A)+(B1)+(C7.27),(A)+(B1)+(C7.28), (A)+(B1)+(C7.29), (A)+(B1)+(C7.30), (A)+(B1)+(C8.1),

(A)+(B2)+(C1.1), (A)+(B2)+(C1.2), (A)+(B2)+(C1.3), (A)+(B2)+(C1.4),(A)+(B2)+(C1.5), (A)+(B2)+(C1.6), (A)+(B2)+(C1.7), (A)+(B2)+(C1.8),(A)+(B2)+(C1.9), (A)+(B2)+(C1.10), (A)+(B2)+(C1.11), (A)+(B2)+(C1.12),(A)+(B2)+(C1.13), (A)+(B2)+(C1.14), (A)+(B2)+(C1.15), (A)+(B2)+(C1.16),(A)+(B2)+(C1.17), (A)+(B2)+(C1.18), (A)+(B2)+(C1.19), (A)+(B2)+(C1.20),(A)+(B2)+(C1.21), (A)+(B2)+(C1.22), (A)+(B2)+(C1.23), (A)+(B2)+(C1.24),(A)+(B2)+(C1.25), (A)+(B2)+(C1.26), (A)+(B2)+(C1.27), (A)+(B2)+(C1.27a),(A)+(B2)+(C1.27b), (A)+(B2)+(C1.27c), (A)+(B2)+(C1.27d),(A)+(B2)+(C1.27e), (A)+(B2)+(C1.27f), (A)+(B2)+(C1.27g),(A)+(B2)+(C1.27h), (A)+(B2)+(C1.27), (A)+(B2)+(C1.27l),(A)+(B2)+(C1.27m), (A)+(B2)+(C1.27n), (A)+(B2)+(C1.27o),(A)+(B2)+(C1.27r), (A)+(B2)+(C1.27s), (A)+(B2)+(C1.27t),(A)+(B2)+(C1.27u), (A)+(B2)+(C1.27v), (A)+(B2)+(C1.28),(A)+(B2)+(C1.29), (A)+(B2)+(C1.30), (A)+(B2)+(C1.31), (A)+(B2)+(C1.32),(A)+(B2)+(C1.33), (A)+(B2)+(C1.34), (A)+(B2)+(C1.35), (A)+(B2)+(C1.36),(A)+(B2)+(C1.37), (A)+(B2)+(C1.38), (A)+(B2)+(C1.39), (A)+(B2)+(C1.40),(A)+(B2)+(C1.41), (A)+(B2)+(C1.42), (A)+(B2)+(C1.43), (A)+(B2)+(C1.44),(A)+(B2)+(C1.45), (A)+(B2)+(C1.46), (A)+(B2)+(C1.47), (A)+(B2)+(C1.48),(A)+(B2)+(C1.49), (A)+(B2)+(C1.50), (A)+(B2)+(C1.51), (A)+(B2)+(C1.52),(A)+(B2)+(C1.53), (A)+(B2)+(C1.54), (A)+(B2)+(C1.55), (A)+(B2)+(C1.56),(A)+(B2)+(C1.57), (A)+(B2)+(C1.58), (A)+(B2)+(C1.59), (A)+(B2)+(C1.60),(A)+(B2)+(C1.61), (A)+(B2)+(C1.62), (A)+(B2)+(C1.63), (A)+(B2)+(C1.64),(A)+(B2)+(C1.65), (A)+(B2)+(C1.66), (A)+(B2)+(C1.67), (A)+(B2)+(C1.68),(A)+(B2)+(C1.69), (A)+(B2)+(C1.70), (A)+(B2)+(C1.71), (A)+(B2)+(C1.72),(A)+(B2)+(C1.73), (A)+(B2)+(C1.74), (A)+(B2)+(C1.75), (A)+(B2)+(C1.76),(A)+(B2)+(C1.77), (A)+(B2)+(C1.78), (A)+(B2)+(C1.79), (A)+(B2)+(C1.80),(A)+(B2)+(C1.81), (A)+(B2)+(C1.82), (A)+(B2)+(C1.83), (A)+(B2)+(C1.84),(A)+(B2)+(C1.85), (A)+(B2)+(C1.86), (A)+(B2)+(C1.87), (A)+(B2)+(C1.88),(A)+(B2)+(C1.89), (A)+(B2)+(C1.90), (A)+(B2)+(C1.91), (A)+(B2)+(C1.92),(A)+(B2)+(C1.93), (A)+(B2)+(C1.94), (A)+(B2)+(C1.95), (A)+(B2)+(C1.96),(A)+(B2)+(C1.97), (A)+(B2)+(C1.98), (A)+(B2)+(C1.99), (A)+(B2)+(C1.100),(A)+(B2)+(C1.101), (A)+(B2)+(C1.102), (A)+(B2)+(C1.103),(A)+(B2)+(C1.104), (A)+(B2)+(C1.105), (A)+(B2)+(C1.106),(A)+(B2)+(C1.107), (A)+(B2)+(C1.108), (A)+(B2)+(C1.109),(A)+(B2)+(C1.110), (A)+(B2)+(C1.111), (A)+(B2)+(C1.112),(A)+(B2)+(C1.113), (A)+(B2)+(C1.114), (A)+(B2)+(C1.115),(A)+(B2)+(C1.116), (A)+(B2)+(C1.117), (A)+(B2)+(C1.118),(A)+(B2)+(C1.119), (A)+(B2)+(C1.120), (A)+(B2)+(C1.121),(A)+(B2)+(C1.122), (A)+(B2)+(C1.123), (A)+(B2)+(C1.124),(A)+(B2)+(C1.125), (A)+(B2)+(C1.126), (A)+(B2)+(C1.127),(A)+(B2)+(C1.128), (A)+(B2)+(C1.129), (A)+(B2)+(C1.130),(A)+(B2)+(C1.131), (A)+(B2)+(C1.132), (A)+(B2)+(C2.1), (A)+(B2)+(C2.2),(A)+(B2)+(C2.3), (A)+(B2)+(C2.4), (A)+(B2)+(C2.5), (A)+(B2)+(C2.6),(A)+(B2)+(C2.7), (A)+(B2)+(C2.8), (A)+(B2)+(C2.9), (A)+(B2)+(C2.10),(A)+(B2)+(C2.11), (A)+(B2)+(C2.12), (A)+(B2)+(C2.13), (A)+(B2)+(C2.14),(A)+(B2)+(C2.15), (A)+(B2)+(C2.16), (A)+(B2)+(C2.17), (A)+(B2)+(C2.18),(A)+(B2)+(C2.19), (A)+(B2)+(C2.20), (A)+(B2)+(C2.21), (A)+(B2)+(C2.22),(A)+(B2)+(C2.23), (A)+(B2)+(C2.24), (A)+(B2)+(C2.25), (A)+(B2)+(C2.26),(A)+(B2)+(C2.27), (A)+(B2)+(C2.28), (A)+(B2)+(C2.29), (A)+(B2)+(C2.30),(A)+(B2)+(C2.31), (A)+(B2)+(C2.32), (A)+(B2)+(C2.33), (A)+(B2)+(C2.34),(A)+(B2)+(C2.35), (A)+(B2)+(C2.36), (A)+(B2)+(C2.37), (A)+(B2)+(C2.38),(A)+(B2)+(C2.39), (A)+(B2)+(C2.40), (A)+(B2)+(C2.41), (A)+(B2)+(C2.42),(A)+(B2)+(C2.43), (A)+(B2)+(C2.44), (A)+(B2)+(C2.45), (A)+(B2)+(C2.46),(A)+(B2)+(C2.47), (A)+(B2)+(C2.48), (A)+(B2)+(C2.49), (A)+(B2)+(C2.50),(A)+(B2)+(C2.51), (A)+(B2)+(C2.52), (A)+(B2)+(C2.53), (A)+(B2)+(C2.54),(A)+(B2)+(C2.55), (A)+(B2)+(C2.56), (A)+(B2)+(C2.57), (A)+(B2)+(C2.58),(A)+(B2)+(C2.59), (A)+(B2)+(C2.60), (A)+(B2)+(C2.61), (A)+(B2)+(C2.62),(A)+(B2)+(C2.63), (A)+(B2)+(C2.64), (A)+(B2)+(C2.65), (A)+(B2)+(C2.66),(A)+(B2)+(C2.67), (A)+(B2)+(C2.68), (A)+(B2)+(C2.69), (A)+(B2)+(C2.70),(A)+(B2)+(C2.71), (A)+(B2)+(C2.72), (A)+(B2)+(C2.73), (A)+(B2)+(C2.74),(A)+(B2)+(C2.75), (A)+(B2)+(C2.76), (A)+(B2)+(C2.77), (A)+(B2)+(C2.78),(A)+(B2)+(C2.79), (A)+(B2)+(C2.80), (A)+(B2)+(C2.81), (A)+(B2)+(C2.82),(A)+(B2)+(C2.83), (A)+(B2)+(C2.84), (A)+(B2)+(C2.85), (A)+(B2)+(C2.86),(A)+(B2)+(C2.87), (A)+(B2)+(C2.88), (A)+(B2)+(C2.89), (A)+(B2)+(C2.90),(A)+(B2)+(C2.91), (A)+(B2)+(C2.92), (A)+(B2)+(C2.93), (A)+(B2)+(C2.94),(A)+(B2)+(C2.95), (A)+(B2)+(C2.96), (A)+(B2)+(C2.97), (A)+(B2)+(C2.98),(A)+(B2)+(C2.99), (A)+(B2)+(C2.100), (A)+(B2)+(C2.101),(A)+(B2)+(C2.102), (A)+(B2)+(C2.103), (A)+(B2)+(C2.104),(A)+(B2)+(C2.105), (A)+(B2)+(C2.106), (A)+(B2)+(C2.107),(A)+(B2)+(C2.108), (A)+(B2)+(C2.109), (A)+(B2)+(C2.110),(A)+(B2)+(C2.111), (A)+(B2)+(C2.112), (A)+(B2)+(C2.113),(A)+(B2)+(C2.114), (A)+(B2)+(C3.1), (A)+(B2)+(C3.2), (A)+(B2)+(C3.3),(A)+(B2)+(C4.1), (A)+(B2)+(C4.2), (A)+(B2)+(C4.3), (A)+(B2)+(C4.4),(A)+(B2)+(C4.5), (A)+(B2)+(C4.6), (A)+(B2)+(C4.7), (A)+(B2)+(C4.8),(A)+(B2)+(C4.9), (A)+(B2)+(C4.10), (A)+(B2)+(C4.11), (A)+(B2)+(C4.12),(A)+(B2)+(C4.13), (A)+(B2)+(C4.14), (A)+(B2)+(C4.15), (A)+(B2)+(C5.1),(A)+(B2)+(C5.2), (A)+(B2)+(C5.3), (A)+(B2)+(C5.4), (A)+(B2)+(C5.5),(A)+(B2)+(C5.6), (A)+(B2)+(C5.7), (A)+(B2)+(C5.8), (A)+(B2)+(C5.9),(A)+(B2)+(C5.10), (A)+(B2)+(C5.11), (A)+(B2)+(C5.12), (A)+(B2)+(C5.13),(A)+(B2)+(C5.14), (A)+(B2)+(C5.15), (A)+(B2)+(C5.16), (A)+(B2)+(C5.17),(A)+(B2)+(C5.18), (A)+(B2)+(C5.19), (A)+(B2)+(C5.20), (A)+(B2)+(C5.21),(A)+(B2)+(C5.22), (A)+(B2)+(C5.23), (A)+(B2)+(C5.24), (A)+(B2)+(C5.25),(A)+(B2)+(C5.26), (A)+(B2)+(C5.27), (A)+(B2)+(C5.28), (A)+(B2)+(C5.29),(A)+(B2)+(C5.30), (A)+(B2)+(C5.31), (A)+(B2)+(C5.32), (A)+(B2)+(C5.33),(A)+(B2)+(C5.34), (A)+(B2)+(C5.35), (A)+(B2)+(C5.36), (A)+(B2)+(C5.37),(A)+(B2)+(C5.38), (A)+(B2)+(C5.39), (A)+(B2)+(C5.40), (A)+(B2)+(C5.41),(A)+(B2)+(C5.42), (A)+(B2)+(C5.43), (A)+(B2)+(C5.44), (A)+(B2)+(C5.45),(A)+(B2)+(C5.46), (A)+(B2)+(C5.47), (A)+(B2)+(C5.48), (A)+(B2)+(C5.49),(A)+(B2)+(C5.50), (A)+(B2)+(C5.51), (A)+(B2)+(C5.52), 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(A)+(B7)+(C2.18),(A)+(B7)+(C2.19), (A)+(B7)+(C2.20), (A)+(B7)+(C2.21), (A)+(B7)+(C2.22),(A)+(B7)+(C2.23), (A)+(B7)+(C2.24), (A)+(B7)+(C2.25), (A)+(B7)+(C2.26),(A)+(B7)+(C2.27), (A)+(B7)+(C2.28), (A)+(B7)+(C2.29), (A)+(B7)+(C2.30),(A)+(B7)+(C2.31), (A)+(B7)+(C2.32), (A)+(B7)+(C2.33), (A)+(B7)+(C2.34),(A)+(B7)+(C2.35), (A)+(B7)+(C2.36), (A)+(B7)+(C2.37), (A)+(B7)+(C2.38),(A)+(B7)+(C2.39), (A)+(B7)+(C2.40), (A)+(B7)+(C2.41), (A)+(B7)+(C2.42),(A)+(B7)+(C2.43), (A)+(B7)+(C2.44), (A)+(B7)+(C2.45), (A)+(B7)+(C2.46),(A)+(B7)+(C2.47), (A)+(B7)+(C2.48), (A)+(B7)+(C2.49), (A)+(B7)+(C2.50),(A)+(B7)+(C2.51), (A)+(B7)+(C2.52), (A)+(B7)+(C2.53), (A)+(B7)+(C2.54),(A)+(B7)+(C2.55), (A)+(B7)+(C2.56), (A)+(B7)+(C2.57), (A)+(B7)+(C2.58),(A)+(B7)+(C2.59), (A)+(B7)+(C2.60), (A)+(B7)+(C2.61), (A)+(B7)+(C2.62),(A)+(B7)+(C2.63), (A)+(B7)+(C2.64), (A)+(B7)+(C2.65), (A)+(B7)+(C2.66),(A)+(B7)+(C2.67), (A)+(B7)+(C2.68), (A)+(B7)+(C2.69), (A)+(B7)+(C2.70),(A)+(B7)+(C2.71), (A)+(B7)+(C2.72), (A)+(B7)+(C2.73), (A)+(B7)+(C2.74),(A)+(B7)+(C2.75), (A)+(B7)+(C2.76), (A)+(B7)+(C2.77), (A)+(B7)+(C2.78),(A)+(B7)+(C2.79), (A)+(B7)+(C2.80), (A)+(B7)+(C2.81), (A)+(B7)+(C2.82),(A)+(B7)+(C2.83), (A)+(B7)+(C2.84), (A)+(B7)+(C2.85), (A)+(B7)+(C2.86),(A)+(B7)+(C2.87), (A)+(B7)+(C2.88), (A)+(B7)+(C2.89), (A)+(B7)+(C2.90),(A)+(B7)+(C2.91), (A)+(B7)+(C2.92), (A)+(B7)+(C2.93), (A)+(B7)+(C2.94),(A)+(B7)+(C2.95), (A)+(B7)+(C2.96), (A)+(B7)+(C2.97), (A)+(B7)+(C2.98),(A)+(B7)+(C2.99), (A)+(B7)+(C2.100), (A)+(B7)+(C2.101),(A)+(B7)+(C2.102), (A)+(B7)+(C2.103), (A)+(B7)+(C2.104),(A)+(B7)+(C2.105), (A)+(B7)+(C2.106), (A)+(B7)+(C2.107),(A)+(B7)+(C2.108), (A)+(B7)+(C2.109), (A)+(B7)+(C2.110),(A)+(B7)+(C2.111), (A)+(B7)+(C2.112), (A)+(B7)+(C2.113),(A)+(B7)+(C2.114), (A)+(B7)+(C3.1), (A)+(B7)+(C3.2), (A)+(B7)+(C3.3),(A)+(B7)+(C4.1), (A)+(B7)+(C4.2), (A)+(B7)+(C4.3), (A)+(B7)+(C4.4),(A)+(B7)+(C4.5), (A)+(B7)+(C4.6), (A)+(B7)+(C4.7), (A)+(B7)+(C4.8),(A)+(B7)+(C4.9), (A)+(B7)+(C4.10), (A)+(B7)+(C4.11), (A)+(B7)+(C4.12),(A)+(B7)+(C4.13), (A)+(B7)+(C4.14), (A)+(B7)+(C4.15), (A)+(B7)+(C5.1),(A)+(B7)+(C5.2), (A)+(B7)+(C5.3), (A)+(B7)+(C5.4), (A)+(B7)+(C5.5),(A)+(B7)+(C5.6), (A)+(B7)+(C5.7), (A)+(B7)+(C5.8), (A)+(B7)+(C5.9),(A)+(B7)+(C5.10), (A)+(B7)+(C5.11), (A)+(B7)+(C5.12), (A)+(B7)+(C5.13),(A)+(B7)+(C5.14), (A)+(B7)+(C5.15), (A)+(B7)+(C5.16), (A)+(B7)+(C5.17),(A)+(B7)+(C5.18), (A)+(B7)+(C5.19), (A)+(B7)+(C5.20), (A)+(B7)+(C5.21),(A)+(B7)+(C5.22), (A)+(B7)+(C5.23), (A)+(B7)+(C5.24), (A)+(B7)+(C5.25),(A)+(B7)+(C5.26), (A)+(B7)+(C5.27), (A)+(B7)+(C5.28), (A)+(B7)+(C5.29),(A)+(B7)+(C5.30), (A)+(B7)+(C5.31), (A)+(B7)+(C5.32), (A)+(B7)+(C5.33),(A)+(B7)+(C5.34), (A)+(B7)+(C5.35), (A)+(B7)+(C5.36), (A)+(B7)+(C5.37),(A)+(B7)+(C5.38), (A)+(B7)+(C5.39), (A)+(B7)+(C5.40), (A)+(B7)+(C5.41),(A)+(B7)+(C5.42), (A)+(B7)+(C5.43), (A)+(B7)+(C5.44), (A)+(B7)+(C5.45),(A)+(B7)+(C5.46), (A)+(B7)+(C5.47), (A)+(B7)+(C5.48), (A)+(B7)+(C5.49),(A)+(B7)+(C5.50), (A)+(B7)+(C5.51), (A)+(B7)+(C5.52), (A)+(B7)+(C5.53),(A)+(B7)+(C5.54), (A)+(B7)+(C5.55), (A)+(B7)+(C5.56), (A)+(B7)+(C5.57),(A)+(B7)+(C5.58), (A)+(B7)+(C5.59), (A)+(B7)+(C5.60), (A)+(B7)+(C5.61),(A)+(B7)+(C5.62), (A)+(B7)+(C5.63), (A)+(B7)+(C5.64), (A)+(B7)+(C5.65),(A)+(B7)+(C6.1), (A)+(B7)+(C6.2), (A)+(B7)+(C6.3), (A)+(B7)+(C6.4),(A)+(B7)+(C6.5), (A)+(B7)+(C6.6), (A)+(B7)+(C6.7), (A)+(B7)+(C6.8),(A)+(B7)+(C6.9), (A)+(B7)+(C6.10), (A)+(B7)+(C6.11), (A)+(B7)+(C6.12),(A)+(B7)+(C6.13), (A)+(B7)+(C6.14), (A)+(B7)+(C6.15), (A)+(B7)+(C6.16),(A)+(B7)+(C6.17), (A)+(B7)+(C7.1), (A)+(B7)+(C7.2), (A)+(B7)+(C7.3),(A)+(B7)+(C7.4), (A)+(B7)+(C7.5), (A)+(B7)+(C7.6), (A)+(B7)+(C7.7),(A)+(B7)+(C7.8), (A)+(B7)+(C7.9), (A)+(B7)+(C7.10), (A)+(B7)+(C7.11),(A)+(B7)+(C7.12), (A)+(B7)+(C7.13), (A)+(B7)+(C7.14), (A)+(B7)+(C7.15),(A)+(B7)+(C7.16), (A)+(B7)+(C7.17), (A)+(B7)+(C7.18), (A)+(B7)+(C7.19),(A)+(B7)+(C7.20), (A)+(B7)+(C7.21), (A)+(B7)+(C7.22), (A)+(B7)+(C7.23),(A)+(B7)+(C7.24), (A)+(B7)+(C7.25), (A)+(B7)+(C7.26), (A)+(B7)+(C7.27),(A)+(B7)+(C7.28), (A)+(B7)+(C7.29), (A)+(B7)+(C7.30), (A)+(B7)+(C8.1),

(A)+(B8)+(C1.1), (A)+(B8)+(C1.2), (A)+(B8)+(C1.3), (A)+(B8)+(C1.4),(A)+(B8)+(C1.5), (A)+(B8)+(C1.6), (A)+(B8)+(C1.7), (A)+(B8)+(C1.8),(A)+(B8)+(C1.9), (A)+(B8)+(C1.10), (A)+(B8)+(C1.11), (A)+(B8)+(C1.12),(A)+(B8)+(C1.13), (A)+(B8)+(C1.14), (A)+(B8)+(C1.15), (A)+(B8)+(C1.16),(A)+(B8)+(C1.17), (A)+(B8)+(C1.18), (A)+(B8)+(C1.19), (A)+(B8)+(C1.20),(A)+(B8)+(C1.21), (A)+(B8)+(C1.22), (A)+(B8)+(C1.23), (A)+(B8)+(C1.24),(A)+(B8)+(C1.25), (A)+(B8)+(C1.26), (A)+(B8)+(C1.27), (A)+(B8)+(C1.27a),(A)+(B8)+(C1.27b), (A)+(B8)+(C1.27c), (A)+(B8)+(C1.27d),(A)+(B8)+(C1.27e), (A)+(B8)+(C1.27f), (A)+(B8)+(C1.27g),(A)+(B8)+(C1.27h), (A)+(B8)+(C1.27), (A)+(B8)+(C1.27l),(A)+(B8)+(C1.27m), (A)+(B8)+(C1.27n), (A)+(B8)+(C1.27o),(A)+(B8)+(C1.27r), (A)+(B8)+(C1.27s), (A)+(B8)+(C1.27t),(A)+(B8)+(C1.27u), (A)+(B8)+(C1.27v), (A)+(B8)+(C1.28),(A)+(B8)+(C1.29), (A)+(B8)+(C1.30), (A)+(B8)+(C1.31), (A)+(B8)+(C1.32),(A)+(B8)+(C1.33), (A)+(B8)+(C1.34), (A)+(B8)+(C1.35), (A)+(B8)+(C1.36),(A)+(B8)+(C1.37), (A)+(B8)+(C1.38), (A)+(B8)+(C1.39), (A)+(B8)+(C1.40),(A)+(B8)+(C1.41), (A)+(B8)+(C1.42), (A)+(B8)+(C1.43), (A)+(B8)+(C1.44),(A)+(B8)+(C1.45), (A)+(B8)+(C1.46), (A)+(B8)+(C1.47), (A)+(B8)+(C1.48),(A)+(B8)+(C1.49), (A)+(B8)+(C1.50), (A)+(B8)+(C1.51), (A)+(B8)+(C1.52),(A)+(B8)+(C1.53), (A)+(B8)+(C1.54), (A)+(B8)+(C1.55), (A)+(B8)+(C1.56),(A)+(B8)+(C1.57), (A)+(B8)+(C1.58), (A)+(B8)+(C1.59), (A)+(B8)+(C1.60),(A)+(B8)+(C1.61), (A)+(B8)+(C1.62), (A)+(B8)+(C1.63), (A)+(B8)+(C1.64),(A)+(B8)+(C1.65), (A)+(B8)+(C1.66), (A)+(B8)+(C1.67), (A)+(B8)+(C1.68),(A)+(B8)+(C1.69), (A)+(B8)+(C1.70), (A)+(B8)+(C1.71), (A)+(B8)+(C1.72),(A)+(B8)+(C1.73), (A)+(B8)+(C1.74), (A)+(B8)+(C1.75), (A)+(B8)+(C1.76),(A)+(B8)+(C1.77), (A)+(B8)+(C1.78), (A)+(B8)+(C1.79), (A)+(B8)+(C1.80),(A)+(B8)+(C1.81), (A)+(B8)+(C1.82), (A)+(B8)+(C1.83), (A)+(B8)+(C1.84),(A)+(B8)+(C1.85), (A)+(B8)+(C1.86), (A)+(B8)+(C1.87), (A)+(B8)+(C1.88),(A)+(B8)+(C1.89), (A)+(B8)+(C1.90), (A)+(B8)+(C1.91), (A)+(B8)+(C1.92),(A)+(B8)+(C1.93), (A)+(B8)+(C1.94), (A)+(B8)+(C1.95), (A)+(B8)+(C1.96),(A)+(B8)+(C1.97), (A)+(B8)+(C1.98), (A)+(B8)+(C1.99), (A)+(B8)+(C1.100),(A)+(B8)+(C1.101), (A)+(B8)+(C1.102), (A)+(B8)+(C1.103),(A)+(B8)+(C1.104), (A)+(B8)+(C1.105), (A)+(B8)+(C1.106),(A)+(B8)+(C1.107), (A)+(B8)+(C1.108), (A)+(B8)+(C1.109),(A)+(B8)+(C1.110), (A)+(B8)+(C1.111), (A)+(B8)+(C1.112),(A)+(B8)+(C1.113), (A)+(B8)+(C1.114), (A)+(B8)+(C1.115),(A)+(B8)+(C1.116), (A)+(B8)+(C1.117), (A)+(B8)+(C1.118),(A)+(B8)+(C1.119), (A)+(B8)+(C1.120), (A)+(B8)+(C1.121),(A)+(B8)+(C1.122), (A)+(B8)+(C1.123), (A)+(B8)+(C1.124),(A)+(B8)+(C1.125), (A)+(B8)+(C1.126), (A)+(B8)+(C1.127),(A)+(B8)+(C1.128), (A)+(B8)+(C1.129), (A)+(B8)+(C1.130),(A)+(B8)+(C1.131), (A)+(B8)+(C1.132), (A)+(B8)+(C2.1), (A)+(B8)+(C2.2),(A)+(B8)+(C2.3), (A)+(B8)+(C2.4), (A)+(B8)+(C2.5), (A)+(B8)+(C2.6),(A)+(B8)+(C2.7), (A)+(B8)+(C2.8), (A)+(B8)+(C2.9), (A)+(B8)+(C2.10),(A)+(B8)+(C2.11), (A)+(B8)+(C2.12), (A)+(B8)+(C2.13), (A)+(B8)+(C2.14),(A)+(B8)+(C2.15), (A)+(B8)+(C2.16), (A)+(B8)+(C2.17), (A)+(B8)+(C2.18),(A)+(B8)+(C2.19), (A)+(B8)+(C2.20), (A)+(B8)+(C2.21), (A)+(B8)+(C2.22),(A)+(B8)+(C2.23), (A)+(B8)+(C2.24), (A)+(B8)+(C2.25), (A)+(B8)+(C2.26),(A)+(B8)+(C2.27), (A)+(B8)+(C2.28), (A)+(B8)+(C2.29), (A)+(B8)+(C2.30),(A)+(B8)+(C2.31), (A)+(B8)+(C2.32), (A)+(B8)+(C2.33), (A)+(B8)+(C2.34),(A)+(B8)+(C2.35), (A)+(B8)+(C2.36), (A)+(B8)+(C2.37), (A)+(B8)+(C2.38),(A)+(B8)+(C2.39), (A)+(B8)+(C2.40), (A)+(B8)+(C2.41), (A)+(B8)+(C2.42),(A)+(B8)+(C2.43), (A)+(B8)+(C2.44), (A)+(B8)+(C2.45), (A)+(B8)+(C2.46),(A)+(B8)+(C2.47), (A)+(B8)+(C2.48), (A)+(B8)+(C2.49), (A)+(B8)+(C2.50),(A)+(B8)+(C2.51), (A)+(B8)+(C2.52), (A)+(B8)+(C2.53), (A)+(B8)+(C2.54),(A)+(B8)+(C2.55), (A)+(B8)+(C2.56), (A)+(B8)+(C2.57), (A)+(B8)+(C2.58),(A)+(B8)+(C2.59), (A)+(B8)+(C2.60), (A)+(B8)+(C2.61), (A)+(B8)+(C2.62),(A)+(B8)+(C2.63), (A)+(B8)+(C2.64), (A)+(B8)+(C2.65), (A)+(B8)+(C2.66),(A)+(B8)+(C2.67), (A)+(B8)+(C2.68), (A)+(B8)+(C2.69), (A)+(B8)+(C2.70),(A)+(B8)+(C2.71), (A)+(B8)+(C2.72), (A)+(B8)+(C2.73), (A)+(B8)+(C2.74),(A)+(B8)+(C2.75), (A)+(B8)+(C2.76), (A)+(B8)+(C2.77), (A)+(B8)+(C2.78),(A)+(B8)+(C2.79), (A)+(B8)+(C2.80), (A)+(B8)+(C2.81), (A)+(B8)+(C2.82),(A)+(B8)+(C2.83), (A)+(B8)+(C2.84), (A)+(B8)+(C2.85), (A)+(B8)+(C2.86),(A)+(B8)+(C2.87), (A)+(B8)+(C2.88), (A)+(B8)+(C2.89), (A)+(B8)+(C2.90),(A)+(B8)+(C2.91), (A)+(B8)+(C2.92), (A)+(B8)+(C2.93), (A)+(B8)+(C2.94),(A)+(B8)+(C2.95), (A)+(B8)+(C2.96), (A)+(B8)+(C2.97), (A)+(B8)+(C2.98),(A)+(B8)+(C2.99), (A)+(B8)+(C2.100), (A)+(B8)+(C2.101),(A)+(B8)+(C2.102), (A)+(B8)+(C2.103), (A)+(B8)+(C2.104),(A)+(B8)+(C2.105), (A)+(B8)+(C2.106), (A)+(B8)+(C2.107),(A)+(B8)+(C2.108), (A)+(B8)+(C2.109), (A)+(B8)+(C2.110),(A)+(B8)+(C2.111), (A)+(B8)+(C2.112), (A)+(B8)+(C2.113),(A)+(B8)+(C2.114), (A)+(B8)+(C3.1), (A)+(B8)+(C3.2), (A)+(B8)+(C3.3),(A)+(B8)+(C4.1), (A)+(B8)+(C4.2), (A)+(B8)+(C4.3), (A)+(B8)+(C4.4),(A)+(B8)+(C4.5), (A)+(B8)+(C4.6), (A)+(B8)+(C4.7), (A)+(B8)+(C4.8),(A)+(B8)+(C4.9), (A)+(B8)+(C4.10), (A)+(B8)+(C4.11), (A)+(B8)+(C4.12),(A)+(B8)+(C4.13), (A)+(B8)+(C4.14), (A)+(B8)+(C4.15), (A)+(B8)+(C5.1),(A)+(B8)+(C5.2), (A)+(B8)+(C5.3), (A)+(B8)+(C5.4), (A)+(B8)+(C5.5),(A)+(B8)+(C5.6), (A)+(B8)+(C5.7), (A)+(B8)+(C5.8), (A)+(B8)+(C5.9),(A)+(B8)+(C5.10), (A)+(B8)+(C5.11), (A)+(B8)+(C5.12), (A)+(B8)+(C5.13),(A)+(B8)+(C5.14), (A)+(B8)+(C5.15), (A)+(B8)+(C5.16), (A)+(B8)+(C5.17),(A)+(B8)+(C5.18), (A)+(B8)+(C5.19), (A)+(B8)+(C5.20), (A)+(B8)+(C5.21),(A)+(B8)+(C5.22), (A)+(B8)+(C5.23), (A)+(B8)+(C5.24), (A)+(B8)+(C5.25),(A)+(B8)+(C5.26), (A)+(B8)+(C5.27), (A)+(B8)+(C5.28), (A)+(B8)+(C5.29),(A)+(B8)+(C5.30), (A)+(B8)+(C5.31), (A)+(B8)+(C5.32), (A)+(B8)+(C5.33),(A)+(B8)+(C5.34), (A)+(B8)+(C5.35), (A)+(B8)+(C5.36), (A)+(B8)+(C5.37),(A)+(B8)+(C5.38), (A)+(B8)+(C5.39), (A)+(B8)+(C5.40), (A)+(B8)+(C5.41),(A)+(B8)+(C5.42), (A)+(B8)+(C5.43), (A)+(B8)+(C5.44), (A)+(B8)+(C5.45),(A)+(B8)+(C5.46), (A)+(B8)+(C5.47), (A)+(B8)+(C5.48), (A)+(B8)+(C5.49),(A)+(B8)+(C5.50), (A)+(B8)+(C5.51), (A)+(B8)+(C5.52), (A)+(B8)+(C5.53),(A)+(B8)+(C5.54), (A)+(B8)+(C5.55), (A)+(B8)+(C5.56), (A)+(B8)+(C5.57),(A)+(B8)+(C5.58), (A)+(B8)+(C5.59), (A)+(B8)+(C5.60), (A)+(B8)+(C5.61),(A)+(B8)+(C5.62), (A)+(B8)+(C5.63), (A)+(B8)+(C5.64), (A)+(B8)+(C5.65),(A)+(B8)+(C6.1), (A)+(B8)+(C6.2), (A)+(B8)+(C6.3), (A)+(B8)+(C6.4),(A)+(B8)+(C6.5), (A)+(B8)+(C6.6), (A)+(B8)+(C6.7), (A)+(B8)+(C6.8),(A)+(B8)+(C6.9), (A)+(B8)+(C6.10), (A)+(B8)+(C6.11), (A)+(B8)+(C6.12),(A)+(B8)+(C6.13), (A)+(B8)+(C6.14), (A)+(B8)+(C6.15), (A)+(B8)+(C6.16),(A)+(B8)+(C6.17), (A)+(B8)+(C7.1), (A)+(B8)+(C7.2), (A)+(B8)+(C7.3),(A)+(B8)+(C7.4), (A)+(B8)+(C7.5), (A)+(B8)+(C7.6), (A)+(B8)+(C7.7),(A)+(B8)+(C7.8), (A)+(B8)+(C7.9), (A)+(B8)+(C7.10), (A)+(B8)+(C7.11),(A)+(B8)+(C7.12), (A)+(B8)+(C7.13), (A)+(B8)+(C7.14), (A)+(B8)+(C7.15),(A)+(B8)+(C7.16), (A)+(B8)+(C7.17), (A)+(B8)+(C7.18), (A)+(B8)+(C7.19),(A)+(B8)+(C7.20), (A)+(B8)+(C7.21), (A)+(B8)+(C7.22), (A)+(B8)+(C7.23),(A)+(B8)+(C7.24), (A)+(B8)+(C7.25), (A)+(B8)+(C7.26), (A)+(B8)+(C7.27),(A)+(B8)+(C7.28), (A)+(B8)+(C7.29), (A)+(B8)+(C7.30), (A)+(B8)+(C8.1).

The following combinations are particularly preferred:

(A)+(B1)+(C1.27), (A)+(B1)+(C1.31), (A)+(B1)+(C2.4), (A)+(B1)+(C2.5),(A)+(B1)+(C2.9), (A)+(B1)+(C2.10), (A)+(B1)+(C2.14), (A)+(B1)+(C8.1),(A)+(B1)+(C1.18), (A)+(B1)+(C2.13), (A)+(B1)+(C2.16), (A)+(B1)+(C7.19),(A)+(B1)+(C7.28), (A)+(B1)+(C1.27a), (A)+(B1)+(C1.27b),(A)+(B1)+(C1.27c), (A)+(B1)+(C1.27d), (A)+(B1)+(C1.27e),(A)+(B1)+(C1.27f).

(A)+(B2)+(C1.27), (A)+(B2)+(C1.31), (A)+(B2)+(C2.4), (A)+(B2)+(C2.5),(A)+(B2)+(C2.9), (A)+(B2)+(C2.10), (A)+(B2)+(C2.14), (A)+(B2)+(C8.1),(A)+(B2)+(C1.18), (A)+(B2)+(C2.13), (A)+(B2)+(C2.16), (A)+(B2)+(C7.19),(A)+(B2)+(C7.28), (A)+(B2)+(C1.27a), (A)+(B2)+(C1.27b),(A)+(B2)+(C1.27c), (A)+(B2)+(C1.27d), (A)+(B2)+(C1.27e),(A)+(B2)+(C1.27f),

(A)+(B3)+(C1.27), (A)+(B3)+(C1.31), (A)+(B3)+(C2.4), (A)+(B3)+(C2.5),(A)+(B3)+(C2.9), (A)+(B3)+(C2.10), (A)+(B3)+(C2.14), (A)+(B3)+(C8.1),(A)+(B3)+(C1.18), (A)+(B3)+(C2.13), (A)+(B3)+(C2.16), (A)+(B3)+(C7.19),(A)+(B3)+(C7.28), (A)+(B3)+(C1.27a), (A)+(B3)+(C1.27b),(A)+(B3)+(C1.27c), (A)+(B3)+(C1.27d), (A)+(B3)+(C1.27e),(A)+(B3)+(C1.27f)

(A)+(B4)+(C1.27), (A)+(B4)+(C1.31), (A)+(B4)+(C2.4), (A)+(B4)+(C2.5),(A)+(B4)+(C2.9), (A)+(B4)+(C2.10), (A)+(B4)+(C2.14), (A)+(B4)+(C8.1),(A)+(B4)+(C1.18), (A)+(B4)+(C2.13), (A)+(B4)+(C2.16), (A)+(B4)+(C7.19),(A)+(B4)+(C7.28), (A)+(B4)+(C1.27a), (A)+(B4)+(C1.27b),(A)+(B4)+(C1.27c), (A)+(B4)+(C1.27d), (A)+(B4)+(C1.27e),(A)+(B4)+(C1.27f);

(A)+(B5)+(C1.27), (A)+(B5)+(C1.31), (A)+(B5)+(C2.4), (A)+(B5)+(C2.5),(A)+(B5)+(C2.9), (A)+(B5)+(C2.10), (A)+(B5)+(C2.14), (A)+(B5)+(C8.1),(A)+(B5)+(C1.18), (A)+(B5)+(C2.13), (A)+(B5)+(C2.16), (A)+(B5)+(C7.19),(A)+(B5)+(C7.28), (A)+(B5)+(C1.27a), (A)+(B5)+(C1.27b),(A)+(B5)+(C1.27c), (A)+(B5)+(C1.27d), (A)+(B5)+(C1.27e),(A)+(B5)+(C1.27f);

(A)+(B6)+(C1.27), (A)+(B6)+(C1.31), (A)+(B6)+(C2.4), (A)+(B6)+(C2.5),(A)+(B6)+(C2.9), (A)+(B6)+(C1.18), (A)+(B6)+(C2.13), (A)+(B6)+(C2.16),(A)+(B6)+(C7.19), (A)+(B6)+(C7.28), (A)+(B6)+(C2.10), (A)+(B6)+(C2.14),(A)+(B6)+(C8.1), (A)+(B6)+(C1.27a), (A)+(B6)+(C1.27b),(A)+(B6)+(C1.27c), (A)+(B6)+(C1.27d), (A)+(B6)+(C1.27e),(A)+(B6)+(C1.27f);

(A)+(B7)+(C1.27), (A)+(B7)+(C1.31), (A)+(B7)+(C2.4), (A)+(B7)+(C2.5),(A)+(B7)+(C2.9), (A)+(B7)+(C2.10), (A)+(B7)+(C2.14), (A)+(B7)+(C8.1),(A)+(B7)+(C1.18), (A)+(B7)+(C2.13), (A)+(B7)+(C2.16), (A)+(B7)+(C7.19),(A)+(B7)+(C7.28), (A)+(B7)+(C1.27a), (A)+(B7)+(C1.27b),(A)+(B7)+(C1.27c), (A)+(B7)+(C1.27d), (A)+(B7)+(C1.27e),(A)+(B7)+(C1.27f);

(A)+(B8)+(C1.27), (A)+(B8)+(C1.31), (A)+(B8)+(C2.4), (A)+(B8)+(C2.5),(A)+(B8)+(C2.9), (A)+(B8)+(C2.10), (A)+(B8)+(C2.14), (A)+(B8)+(C8.1),(A)+(B8)+(C1.18), (A)+(B8)+(C2.13), (A)+(B8)+(C2.16), (A)+(B8)+(C7.19),(A)+(B8)+(C7.28), (A)+(B8)+(C1.27a), (A)+(B8)+(C1.27b),(A)+(B8)+(C1.27c), (A)+(B8)+(C1.27d), (A)+(B8)+(C1.27e),(A)+(B8)+(C1.27f).

The invention is further directed to the preparation of a compositioncontaining compound (A), spore-forming bacteria (B) and at least onebiological control agent (C) selected from bacteria, in particularspore-forming bacteria, fungi or yeasts, protozoas, viruses, andentomopathogenic nematodes, inoculants, botanicals, and productsproduced by microorganisms including proteins or secondary metabolitesparticularly (C8.1) Harpin, for reducing overall damage of plants andplant parts as well as losses in harvested fruits or vegetables causedby insects, nematodes or phytopathogens.

The invention is also directed to a method for reducing overall damageof plants and plant parts as well as losses in harvested fruits orvegetables caused by insects, nematodes or phytopathogens comprising thestep of simultaneously or sequentially applying compound (A),spore-forming bacteria (B) and at least one biological control agent (C)selected from bacteria, in particular spore-forming bacteria, fungi oryeasts, protozoas, viruses, and entomopathogenic nematodes, inoculantsbotanicals, and products produced by microorganisms including proteinsor secondary metabolites, particularly (C8.1) Harpin, on the plant,plant parts, harvested fruits or vegetables.

As already mentioned before, using compound (A), spore-forming bacteria(B) and at least one biological control agent (C) selected frombacteria, in particular spore-forming bacteria, fungi or yeasts,protozoas, viruses, and entomopathogenic nematodes, inoculants,botanicals, and products produced by microorganisms including proteinsor secondary metabolites, particularly (C8.1) Harpin as a combination isadvantageous. The broadening of the activity spectrum to otheragricultural pests (i.e. insects, acari, nematodes, and phytopathogens)and, for example to resistant strains of such agricultural pests orplant diseases can be achieved.

Also according to the invention, the compound (A) Fluopyram, (B) aspore-forming bacterium of the genera Bacillus, selected from Bacillusfirmus, Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis,Bacillus amyloliquefaciens, Bacillus subtilis strain GB03, Bacillussubtilis strain QST713, and (C) a biological control agent, inparticular bacteria, fungi or yeasts, protozoa, viruses,entomopathogenic nematodes, inoculants, botanicals and products producedby microorganisms including proteins or secondary metabolites,particularly (C8.1) Harpin can be used in a lower application rate andstill achieve the sufficient control of the agricultural pests or plantdiseases. This is particularly visible if application rates for thebefore mentioned compounds or biological control agents are used wherethe individual compounds or biological control agents show no orvirtually no activity. Moreover, even an enhanced systemic action ofcompound (A) Fluopyram, (B) a spore-forming bacterium of the generaBacillus, selected from Bacillus firmus, Bacillus firmus CNCM I-1582,Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillussubtilis strain GB03, Bacillus subtilis strain QST713, and (C) abiological control agent, in particular bacteria, fungi or yeasts,protozoa, viruses, entomopathogenic nematodes, inoculants, botanicalsand products produced by microorganisms including proteins or secondarymetabolites, particularly (C8.1) Harpin is higher or a persistency ofthe fungicidal, insecticidal, acaricidal or nematicidal action isexpected.

Plant Physiology Effects

Also according to the invention, the compound (A) Fluopyram, (B) aspore-forming bacterium of the genera Bacillus, selected from Bacillusfirmus, Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis,Bacillus amyloliquefaciens, Bacillus subtilis strain GB03, Bacillussubtilis strain QST713, and (C) a biological control agent, inparticular bacteria, fungi or yeasts, protozoa, viruses,entomopathogenic nematodes, inoculants, botanicals and products producedby microorganisms including proteins or secondary metabolites,particularly (C8.1) Harpin can be used for improving plant physiologyeffects.

In context with the present invention plant physiology effects comprisethe following:

Abiotic stress tolerance, comprising temperature tolerance, droughttolerance and recovery after drought stress, water use efficiency(correlating to reduced water consumption), flood tolerance, ozonestress and UV tolerance, tolerance towards chemicals like heavy metals,salts, pesticides (safener) etc.

Biotic stress tolerance, comprising increased fungal resistance andincreased resistance against nematodes, viruses and bacteria. In contextwith the present invention, biotic stress tolerance preferably comprisesincreased fungal resistance and increased resistance against nematodes

Increased plant vigor, comprising plant health/plant quality and seedvigor, reduced stand failure, improved appearance, increased recovery,improved greening effect and improved photosynthetic efficiency.

Effects on plant hormones or functional enzymes.

Effects on growth regulators (promoters), comprising earliergermination, better emergence, more developed root system or improvedroot growth, increased ability of filtering, more productive tillers,earlier flowering, increased plant height or biomass, shorting of stems,improvements in shoot growth, number of kernels/ear, number of ears/m²,number of stolons or number of flowers, enhanced harvest index, biggerleaves, less dead basal leaves, improved phyllotaxy, earliermaturation/earlier fruit finish, homogenous riping, increased durationof grain filling, better fruit finish, bigger fruit/vegetable size,sprouting resistance and reduced lodging.

Increased yield, referring to total biomass per hectare, yield perhectare, kernel/fruit weight, seed size or hectolitre weight as well asto increased product quality, comprising:

improved processability relating to size distribution (kernel, fruit,etc.), homogenous riping, grain moisture, better milling, bettervinification, better brewing, increased juice yield, harvestability,digestibility, sedimentation value, falling number, pod stability,storage stability, improved fiber length/strength/uniformity, increaseof milk or meet quality of silage fed animals, adaption to cooking andfrying;further comprising improved marketability relating to improvedfruit/grain quality, size distribution (kernel, fruit, etc.), increasedstorage/shelf-life, firmness/softness, taste (aroma, texture, etc.),grade (size, shape, number of berries, etc.), number of berries/fruitsper bunch, crispness, freshness, coverage with wax, frequency ofphysiological disorders, colour, etc.;further comprising increased desired ingredients such as e.g. proteincontent, fatty acids, oil content, oil quality, aminoacid composition,sugar content, acid content (pH), sugar/acid ratio (Brix), polyphenols,starch content, nutritional quality, gluten content/index, energycontent, taste, etc.;and further comprising decreased undesired ingredients such as e.g. lessmycotoxins, less aflatoxines, geosmin level, phenolic aromas, lacchase,polyphenol oxidases and peroxidases, nitrate content etc.

Sustainable agriculture, comprising nutrient use efficiency, especiallynitrogen (N)-use efficiency, phosphours (P)-use efficiency, water useefficiency, improved transpiration, respiration or CO₂ assimilationrate, better nodulation, improved Ca-metabolism etc.

Delayed senescence, comprising improvement of plant physiology which ismanifested, for example, in a longer grain filling phase, leading tohigher yield, a longer duration of green leaf colouration of the plantand thus comprising colour (greening), water content, dryness etc.Accordingly, in the context of the present invention, it has been foundthat the specific inventive application of the active compoundcombination makes it possible to prolong the green leaf area duration,which delays the maturation (senescence) of the plant. The mainadvantage to the farmer is a longer grain filling phase leading tohigher yield. There is also an advantage to the farmer on the basis ofgreater flexibility in the harvesting time.

Therein “sedimentation value” is a measure for protein quality anddescribes according to Zeleny (Zeleny value) the degree of sedimentationof flour suspended in a lactic acid solution during a standard timeinterval. This is taken as a measure of the baking quality. Swelling ofthe gluten fraction of flour in lactic acid solution affects the rate ofsedimentation of a flour suspension. Both a higher gluten content and abetter gluten quality give rise to slower sedimentation and higherZeleny test values. The sedimentation value of flour depends on thewheat protein composition and is mostly correlated to the proteincontent, the wheat hardness, and the volume of pan and hearth loaves. Astronger correlation between loaf volume and Zeleny sedimentation volumecompared to SDS sedimentation volume could be due to the protein contentinfluencing both the volume and Zeleny value (Czech J. Food Sci. Vol.21, No. 3: 91-96, 2000).

Further the “falling number” as mentioned herein is a measure for thebaking quality of cereals, especially of wheat. The falling number testindicates that sprout damage may have occurred. It means that changes tothe physical properties of the starch portion of the wheat kernel hasalready happened. Therein, the falling number instrument analyzesviscosity by measuring the resistance of a flour and water paste to afalling plunger. The time (in seconds) for this to happen is known asthe falling number. The falling number results are recorded as an indexof enzyme activity in a wheat or flour sample and results are expressedin time as seconds. A high falling number (for example, above 300seconds) indicates minimal enzyme activity and sound quality wheat orflour. A low falling number (for example, below 250 seconds) indicatessubstantial enzyme activity and sprout-damaged wheat or flour.

The term “more developed root system”/“improved root growth” refers tolonger root system, deeper root growth, faster root growth, higher rootdry/fresh weight, higher root volume, larger root surface area, biggerroot diameter, higher root stability, more root branching, higher numberof root hairs, or more root tips and can be measured by analyzing theroot architecture with suitable methodologies and Image analysisprogrammes (e.g. WinRhizo).

The term “crop water use efficiency” refers technically to the mass ofagriculture produce per unit water consumed and economically to thevalue of product(s) produced per unit water volume consumed and can e.g.be measured in terms of yield per ha, biomass of the plants,thousand-kernel mass, and the number of ears per m2.

The term “nitrogen-use efficiency” refers technically to the mass ofagriculture produce per unit nitrogen consumed and economically to thevalue of product(s) produced per unit nitrogen consumed, reflectinguptake and utilization efficiency.

Improvement in greening/improved colour and improved photosyntheticefficiency as well as the delay of senescence can be measured withwell-known techniques such as a HandyPea system (Hansatech). Fv/Fm is aparameter widely used to indicate the maximum quantum efficiency ofphotosystem II (PSII). This parameter is widely considered to be aselective indication of plant photosynthetic performance with healthysamples typically achieving a maximum Fv/Fm value of approx. 0.85.Values lower than this will be observed if a sample has been exposed tosome type of biotic or abiotic stress factor which has reduced thecapacity for photochemical quenching of energy within PSII. Fv/Fm ispresented as a ratio of variable fluorescence (Fv) over the maximumfluorescence value (Fm). The Performance Index is essentially anindicator of sample vitality. (See e.g. Advanced Techniques in SoilMicrobiology, 2007, 11, 319-341; Applied Soil Ecology, 2000, 15,169-182.)

The improvement in greening/improved colour and improved photosyntheticefficiency as well as the delay of senescence can also be assessed bymeasurement of the net photosynthetic rate (Pn), measurement of thechlorophyll content, e.g. by the pigment extraction method of Zieglerand Ehle, measurement of the photochemical efficiency (Fv/Fm ratio),determination of shoot growth and final root or canopy biomass,determination of tiller density as well as of root mortality.

Within the context of the present invention preference is given toimproving plant physiology effects which are selected from the groupcomprising: enhanced root growth/more developed root system, improvedgreening, improved water use efficiency (correlating to reduced waterconsumption), improved nutrient use efficiency, comprising especiallyimproved nitrogen (N)-use efficiency, delayed senescence and enhancedyield.

Within the enhancement of yield preference is given as to an improvementin the sedimentation value and the falling number as well as to theimprovement of the protein and sugar content—especially with plantsselected from the group of cereals (preferably wheat).

Preferably the novel use of the fungicidal or nematicidal or pestidicalcompositions of the present invention relates to a combined use of a)preventively or curatively controlling insects, nematodes orphytopathogens, and b) at least one of enhanced root growth, improvedgreening, improved water use efficiency, delayed senescence and enhancedyield. From group b) enhancement of root system, water use efficiencyand N-use efficiency is particularly preferred.

The compound (A) Fluopyram, (B) a spore-forming bacterium of the generaBacillus, selected from Bacillus firmus, Bacillus firmus CNCM I-1582,Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillussubtilis strain GB03, Bacillus subtilis strain QST713, and (C) abiological control agent, in particular bacteria, fungi or yeasts,protozoa, viruses, entomopathogenic nematodes, inoculants, botanicalsand products produced by microorganisms including proteins or secondarymetabolites, particularly (C8.1) Harpin may be applied in any desiredmanner, such as in the form of a seed coating, soil drench, or directlyin-furrow or as a foliar spray and applied either pre-emergence,post-emergence or both. In other words, the composition can be appliedto the seed, the plant or to harvested fruits and vegetables or to thesoil wherein the plant is growing or wherein it is desired to grow.

The term “controlling” stands for a reduction of the damage on the plantor plant parts as well as losses in harvested fruits or vegetablescaused by insects, nematodes or phytopathogens of at least 30%,preferably 50%, more preferably 60%, more preferably 75%, morepreferably 80%, more preferably 90%, when compared to the untreatedcontrol.

If not mentioned otherwise, the expression “combination” stands for thevarious combinations of the compound (A) Fluopyram, (B) a spore-formingbacterium of the genera Bacillus, selected from Bacillus firmus,Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillusamyloliquefaciens, Bacillus subtilis strain GB03, Bacillus subtilisstrain QST713, and (C) a biological control agent, in particularbacteria, fungi or yeasts, protozoa, viruses, entomopathogenicnematodes, inoculants, botanicals and products produced bymicroorganisms including proteins or secondary metabolites, particularly(C8.1) Harpin in a solo-formulation, in a single “ready-mix” form, in acombined spray mixture composed from solo-formulations, such as a“tank-mix”, and especially in a combined use of the single activeingredients when applied in a sequential manner, i.e. one after theother within a reasonably short period, such as a few hours or days,e.g. 2 hours to 7 days. The order of applying compound (A),spore-forming bacteria (B) and at least one biological control agent (C)selected from bacteria, in particular spore-forming bacteria, fungi oryeasts, protozoal, viruses, and entomopathogenic nematodes, inoculants,botanicals, and products produced by microorganisms including proteinsor secondary metabolites, particularly (C8.1) Harpin is not essentialfor working the present invention.

Accordingly, the term “combination” also encompasses the presence of thecompound (A) Fluopyram, (B) a spore-forming bacterium of the generaBacillus, selected from Bacillus firmus, Bacillus firmus CNCM I-1582,Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillussubtilis strain GB03, Bacillus subtilis strain QST713, and (C) abiological control agent, in particular bacteria, fungi or yeasts,protozoa, viruses, entomopathogenic nematodes, inoculants, botanicalsand products produced by microorganisms including proteins or secondarymetabolites, particularly (C8.1) Harpin on or in a plant to be treatedor its surrounding, habitat or storage space, e.g. after simultaneouslyor consecutively applying compound (A) Fluopyram, (B) a spore-formingbacterium of the genera Bacillus, selected from Bacillus firmus,Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillusamyloliquefaciens, Bacillus subtilis strain GB03, Bacillus subtilisstrain QST713, and (C) a biological control agent, in particularbacteria, fungi or yeasts, protozoa, viruses, entomopathogenicnematodes, inoculants, botanicals and products produced bymicroorganisms including proteins or secondary metabolites, particularly(C8.1) Harpin to a plant its surrounding, habitat or storage space.

A solo- or combined-formulation is the formulation which is applied tothe plants to be treated (e.g., in a greenhouse, on a field, in a wood),e.g., a tank formulation comprising the biological control agent inaccordance with the present invention and a compound (A) or a liquid orsolid formulation comprising component (B) and the biological controlagent (C) which is applied prior, after or in parallel with a compound(A) to a plant to be treated.

If the compound (A) Fluopyram, (B) a spore-forming bacterium of thegenera Bacillus, selected from Bacillus firmus, Bacillus firmus CNCMI-1582, Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens,Bacillus subtilis strain GB03, Bacillus subtilis strain QST713, and (C)a biological control agent, in particular bacteria, fungi or yeasts,protozoa, viruses, entomopathogenic nematodes, inoculants, botanicalsand products produced by microorganisms including proteins or secondarymetabolites, particularly (C8.1) Harpin are employed or used in asequential manner, it is preferred to treat the plants or plant parts(which includes seeds and plants emerging from the seed), harvestedfruits and vegetables according to the following method: Firstlyapplying the compound (A) on the plant or plant parts, and secondlyapplying (B) the spore-forming bacteria and (C) the biological controlagent selected from bacteria, in particular spore-forming bacteria,fungi or yeasts, protozoal, viruses, and entomopathogenic nematodes,inoculant, botanicals and products produced by microorganisms includingproteins or secondary metabolites, particularly (C8.1) Harpin to thesame plant or plant parts. The time periods between the first and thesecond application within a (crop) growing cycle may vary and depend onthe effect to be achieved. For example, the first application is done toprevent an infestation of the plant or plant parts with insects,nematodes or phytopathogens (this is particularly the case when treatingseeds) or to combat the infestation with insects, nematodes orphytopathogens (this is parparticularly the case when treating plantsand plant parts) and the second application is done to prevent orcontrol the infestation with insects, nematodes or phytopathogens.Control in this context means that the biological control agent is notable to fully exterminate the pests or phytopathogenic fungi but is ableto keep the infestation on an acceptable level.

By following the before mentioned steps, a very low level of residues ofthe compound (A) on the treated plant, plant parts, and the harvestedfruits and vegetables can be achieved.

In general, the terms “spore-forming bacteria”, “fungi” or “yeasts”comprise all stages of bacteria, fungi and yeast including restingspores, conidia, blastospores, filamentous stages and other inactiveforms of said organisms which can yield in active organisms. Thus, inone embodiment, said organisms are comprised in form of spores in aformulation, e.g., a solo- or combined-formulation.

In general, the term “nematode” comprises eggs, larvae, juvenile andmature forms of said organism. Thus, in one embodiment, said organismsare comprised in form of eggs, larvae, juvenile or mature form in aformulation, e.g., a solo- or combined-formulation.

Nematodes are microscopic unsegmented worms known to reside in virtuallyevery type of environment (terrestrial, freshwater, marine). Of the over80,000 known species many are agriculturally significant, particularlythose classified as pests. One such species is the root knot nematodewhich attacks a broad range of plants, shrubs and crops. These soil-bornnematodes attack newly formed roots causing stunted growth, swelling orgall formation. The roots may then crack open thus exposing the roots toother microorganisms such as bacteria or fungi. With environmentallyfriendly practices such as reduced or no tillage farming, and variousnematode species acquiring resistance to transgenic seed, nematoderelated crop losses appear to be on the rise.

Chemical nematicides such as soil fumigants or non-fumigants have beenin use for many years to combat nematode infestations. Such nematicidesmay require repeated applications of synthetic chemicals to the groundprior to planting. Due to their toxicity, chemical nematicides have comeunder scrutiny from the Environmental Protection Agency (EPA) and insome cases their use has been limited or restricted by the EPA. As theuse of traditional chemical nematicides such as methyl-bromide andorganophosphates continue to be phased out, a need for the developmentof alternative treatment options has arisen.

The term “plant to be treated” encompasses every part of a plantincluding its root system and the material—e.g., soil or nutritionmedium—which is in a radius of at least 10 cm, 20 cm, 30 cm around thebole of a plant to be treated or which is at least 10 cm, 20 cm, 30 cmaround the root system of said plant to be treated, respectively.

As already mentioned, the compound (A) Fluopyram, (B) a spore-formingbacterium of the genera Bacillus, selected from Bacillus firmus,Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillusamyloliquefaciens, Bacillus subtilis strain GB03, Bacillus subtilisstrain QST713, and (C) a biological control agent, in particularbacteria, fungi or yeasts, protozoa, viruses, entomopathogenicnematodes, inoculants, botanicals and products produced bymicroorganisms including proteins or secondary metabolites, particularly(C8.1) Harpin can be employed or used according to the invention as asolo- or a combined-formulation. Such formulations may includeagriculturally suitable auxiliaries, solvents, carriers, surfactants orextenders.

If the active compounds in the active compound combinations according tothe invention are present in certain weight ratios, the synergisticeffect is particularly pronounced. However, the weight ratios of theactive compounds in the active compound combinations can be variedwithin a relatively wide range.

In general, from 0.01 to 100 parts by weight, preferably from 0.05 to 20parts by weight, particularly preferably from 0.1 to 10 parts by weight,of active compound of group (B) and from 0.01 to 100 parts by weight,preferably from 0.05 to 20 parts by weight, particularly preferably from0.1 to 10 parts by weight, of active compound of group (C) are presentper part by weight of active compound (A) Fluopyram. The mixing ratio ispreferably to be chosen such that a synergistic active compoundcombination is obtained.

The weight ratio (A), (B) and (C) is selected as to give the desired,for example synergistic, action. In general, the weight ratio would varydepending on the specific active compound. Generally the weight ratiobetween any of (A), (B) and (C), independently of each other, is from500 000:1 to 1:500 000, preferably 200 000:1 to 1:200 000, morepreferably, 100 000:1 to 1:100 000, and most preferably 50 000:1 to 1:50000.

Further weight ratio between any of (A), (B) and (C), independently ofeach other, which can be used according to the present invention withincreasing preference in the order given are 75 000:1 to 1:75 000, 25000:1 to 1:25 000, 20 000:1 to 1:20 000, 10 000:1 to 1:10 000, 5000:1 to1:5000, 2500:1 to 1:2500, 2000:1 to 1:2000, 1000:1 to 1:1000, 750:1 to1:750, 500:1 to 1:500, 250:1 to 1:250, 200:1 to 1:200, 100:1 to 1:100,95:1 to 1:95, 90:1 to 1:90, 85:1 to 1:85, 80:1 to 1:80, 75:1 to 1:75,70:1 to 1:70, 65:1 to 1:65, 60:1 to 1:60, 55:1 to 1:55, 45:1 to 1:45,40:1 to 1:40, 35:1 to 1:35, 30:1 to 1:30, 25:1 to 1:25, 15:1 to 1:15,10:1 to 1:10, 5:1 to 1:5, 4:1 to 1:4, 3:1 to 1:3, 2:1 to 1:2.

Further weight ratio between any of (A), (B) and (C) are 1:200 000:20000, 1:200 000:10 000.

It has to be noted that before mentioned ratios ranges are based on athe spore preparation of the bacteria, fungi or yeasts which contains10⁹-10¹⁰ spores (fungi or bacteria) or cells (yeast or bacteria) pergram. If spore preparations vary in density, the ratios have to beadapted accordingly to match the above listed ratio ranges. A ratio of1:100 means 100 weight parts of the spore or cell preparation of thefungi or yeast to 1 weight part of the compound (A).

The amount of the biological control agent (C) selected from bacteria,in particular spore-forming bacteria, fungi or yeasts, protozoas,viruses, and entomopathogenic which is used or employed in combinationwith compound (A) Fluopyram, (B) a spore-forming bacterium of the generaBacillus, selected from Bacillus firmus, Bacillus firmus CNCM I-1582,Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillussubtilis strain GB03, Bacillus subtilis strain QST713, and (C) abiological control agent, in particular bacteria, fungi or yeasts,protozoa, viruses, entomopathogenic nematodes, inoculants, botanicalsand products produced by microorganisms including proteins or secondarymetabolites, particularly (C8.1) Halpin, depends on the finalformulation as well as size or type of the plant, plant parts, seeds,harvested fruits and vegetables to be treated. Usually, the biologicalcontrol agent to be employed or used according to the invention ispresent in about 2% to about 80% (w/w), preferably in about 5% to about75% (w/w), more preferably about 10% to about 70% (w/w) of itssolo-formulation or combined-formulation with the compound of formula(I), and optionally the inoculant.

If bacteria, fungi or yeasts are selected as biological control agent,in particular those who are named as being preferred, it is preferredthat they are present in a solo-formulation or the combined-formulationin a concentration in excess of 10⁵-10¹² cfu/g (colony forming units pergram), preferably in excess of 10⁶-10¹¹ cfu/g, more preferably 10⁷-10¹⁰cfu cfu/g and most preferably about 10⁹ cfu/g.

It is preferred to employ or use compound (A) Fluopyram, (B) aspore-forming bacterium of the genera Bacillus, selected from Bacillusfirmus, Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis,Bacillus amyloliquefaciens, Bacillus subtilis strain GB03, Bacillussubtilis strain QST713, and (C) a biological control agent, inparticular bacteria, fungi or yeasts, protozoa, viruses,entomopathogenic nematodes, inoculants, botanicals and products producedby microorganisms including proteins or secondary metabolites,particularly (C8.1) Harpin in a synergistic weight ratio. The skilledperson is able to find out the synergistic weight ratios for the presentinvention by routine methods. The skilled person understands that theseratios refer to the ratio within a combined-formulation as well as tothe calculative ratio of compound (A) Fluopyram and the biologicalcontrol agent described herein when both components are applied asmono-formulations to a plant to be treated. The skilled person cancalculate this ratio by simple mathematics since the volume and theamount of compound (A), compound (B) and the biological control agent(C), respectively, in a mono-formulation is known to the skilled person.In one embodiment, the said ratio refer to the ratio of the threecomponents after all three components, i.e. compound (A), compound (B)and the biological control agent (C), respectively, were applied to aplant to be treated independently whether the components were applied toa plant to be treated in form of solo-applications or in form of acombined-formulation.

It is preferred to employ or use the compound (A), compound (B) and thebiological control agent (C), and in a synergistic weight ratio. Theskilled person is able to find out the synergistic weight ratios for thepresent invention by routine methods. The skilled person understandsthat these ratios refer to the ratio within a combined-formulation aswell as to the calculative ratio of compound (A), compound (B) and thebiological control agent (C) described herein when both components areapplied as mono-formulations to a plant to be treated. The skilledperson can calculate this ratio by simple mathematics since the volumeand the amount of compound (A), compound (B) and the biological controlagent (C), respectively, in a mono-formulation is known to the skilledperson. In one embodiment, the said ratio refer to the ratio of the bothcomponents after all three components, i.e. compound (A), compound (B)and the biological control agent (C), respectively, were applied to aplant to be treated independently whether the components were applied toa plant to be treated in form of solo-applications or in form of acombined-formulation.

In one embodiment of the present invention, a biological control agent(C) is a bacterium and the concentration of the bacteria after dispersalis at least 50 g/ha, at least 100 g/ha or at least 150 g/ha.

In one embodiment of the present invention, a biological control agent(C) is a bacterium, and the concentration of the bacteria afterdispersal is at least 2.5 g/ha (hectare), such as 2.5-7500 g/ha, 5-2500g/ha, 5-1500 g/ha; at least 250 g/ha; at least 100 g/ha, such as100-5000 g/ha, 100-2500 g/ha, 100-1500 g/ha or 100-250 g/ha; or at least800 g/ha, such as 800-5000 g/ha or 800-2500 g/ha.

In another embodiment of the present invention, a biological controlagent (C) is a bacterium, such as B. firmus e.g., strain CNCM I-1582,and the concentration of the bacteria after dispersal is at least 50g/ha such as 50-5000 g/ha, 50-2500 g/ha, 50-200 g/ha; at least 100 g/ha,at least 500 g/ha, at least 800 g/ha, such as 800-5000 g/ha or 800-2500g/ha.

In another embodiment of the present invention, a biological controlagent (C) is a bacterium, such as B. subtilis, e.g., strain GB 03, andthe concentration of the bacteria after dispersal is at least 50 g/hasuch as 50-5000 g/ha, 50-2500 g/ha, 50-200 g/ha; at least 100 g/ha, atleast 500 g/ha, at least 800 g/ha, such as 800-5000 g/ha or 800-2500g/ha.

In another embodiment of the present invention, a biological controlagent (C) is a bacterium, such as B. subtilis, e.g., strain QST713, andthe concentration of the bacteria after dispersal is at least 50 g/hasuch as 50-5000 g/ha, 50-2500 g/ha, 50-200 g/ha; at least 100 g/ha, atleast 500 g/ha, at least 800 g/ha, such as 800-5000 g/ha or 800-2500g/ha.

In another embodiment of the present invention, a biological controlagent (C) is a bacterium, such as B. amyloliquefaciens and theconcentration of the bacteria after dispersal is at least 500 g/ha, suchas 500-5000 g/ha, 500-2500 g/ha.

In one embodiment of the present invention, a biological control agent(C) is a fungus and the concentration of the fungus after dispersal isat least 1 g/ha, such as 1-7500 g/ha, 1-2500 g/ha, 1-1500 g/ha; at least250 g/ha (hectare), at least 500 g/ha or at least 800 g/ha.

In one embodiment of the present invention, a biological control agent(C) is a fungus, such as Paecilomyces lilacinus, e.g., strain 251, andthe concentration of the fungus after dispersal is at least 50 g/ha;

at least 100 g/ha; at least 1000 g/ha; at least 2500 g/ha, such as2500-7500 g/ha, 2500-6000 g/ha; or at least 4000 g/ha, such as 4000-6000g/ha.

In one embodiment of the present invention, a biological control agent(C) is a fungus, such as Metarhizium anisopliae, e.g., strain F52 andthe concentration of the fungus after dispersal is at least 1 g/ha, suchas 1-7500 g/ha, 1-2500 g/ha, 1-250 g/ha; or at least 100 g/ha, such as100 g/ha-1000 g/ha or 100-250 g/ha.

In one embodiment of the present invention, a biological control agent(C) is yeast, such as Metschnikowia fructicola, and the concentration ofthe yeast after dispersal is at least 50 g/ha, such as 50-5000 g/ha,50-2000 g/ha; at least 1000 g/ha; at least 1500 g/ha, such as 500-5000g/ha, 500-2500 g/ha, 500-2000 g/ha.

In one embodiment of the present invention, a biological control agent(C) is a virus and the concentration of the virus after dispersal is atleast 50 g/ha such as 50-7500 g/ha, 50-2500 g/ha, 50-1500 g/ha; at least100 g/ha or at least 150 g/ha.

In one embodiment of the present invention, a biological control agent(C) is a virus, such as Codling moth (Cydia pomonella) granulosis virusand the concentration of the virus after dispersal is at least 50 g/ha(hectare) such as 50-5000 g/ha, 50-2500 g/ha, 50-1500 g/ha or 50-250g/ha; or at least 100 g/ha, such as 100-500 g/ha or 100-250 g/ha.

In one embodiment of the present invention, a biological control agent(C) is an entomopathogenic nematode and the concentration of thenematodes is at least 10⁶ nematodes/ha, e.g., larval stage nematodes/ha,such as 10⁶-10¹⁵ nematodes/ha, e.g., larval stage nematodes/ha, 10⁶-10¹²nematodes/ha, e.g., larval stage nematodes/ha, at least 10⁸nematodes/ha, e.g., larval stage nematodes/ha such as 10⁸-10¹⁵nematodes/ha, e.g., larval stage nematodes/ha, 10⁸-10¹² nematodes/ha,e.g., larval stage nematodes/ha; or at least 10⁹ nematodes/ha, e.g.,larval stage nematodes/ha, such as 10⁹-10¹⁵ nematodes/ha, e.g., larvalstage nematodes/ha or 10⁹-10¹² nematodes/ha, e.g., larval stagenematodes/ha.

In one embodiment of the present invention, the ratios between (B) aspore-forming bacterium of the genera Bacillus, selected from Bacillusfirmus, Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis,Bacillus amyloliquefaciens, Bacillus subtilis strain GB03, Bacillussubtilis strain QST713 and compound (A) in a solo- orcombined-formulation or on or in a plant to be treated or itssurrounding, habitat or storage space is between 500 000:1 to 1:500 000,preferably 200 000:1 to 1:200 000, more preferably, 100 000:1 to 1:100000, and most preferably 50 000:1 to 1:50 000.

In one embodiment of the present invention, the ratios between fungi(such as Metarhizium anisopliae, Paecilomyces lilacinus, Beauveriabassiana, Nomuraea rileyi) and compound (A) in a solo- orcombined-formulation or on or in a plant to be treated or itssurrounding, habitat or storage space is between 50000:1 to 1:125,between 25000:1 to 1:25 or even 500:1 to 1:5.

In one embodiment of the present invention, the ratios between yeast(such as Metschnikowia fructicola) and compound (A) in a solo- orcombined-formulation or on or in a plant to be treated or itssurrounding, habitat or storage space is between 2500:1 to 1:125,between 1250:1 and 1:125 between 125:1 to 1:50, between 100:1 to 1:25 oreven 50:1 to 1:5.

In one embodiment of the present invention, the ratios between nematodes(such as Steinernema feltiae and Steinernema carpocapsae) and compound(A) in a solo- or combined-formulation or on or in a plant to be treatedor its surrounding, habitat or storage space is between 125:1 to 1:125,between 100:1 to 1:25 or even 50:1 to 1:5.

The application rate of the biological control agent selected frombacteria, in particular spore-forming bacteria, fungi or yeasts,protozoas, viruses, entomopathogenic nematodes, botanicals and productsproduced by microorganisms including proteins or secondary metabolites,particularly (C8.1) Harpin to be employed or used according to thepresent invention may vary. The skilled person is able to find theappropriate application rate by way of routine experiments.

Microorganisms such as fungi or bacteria can be obtained by conventionalfermentation processes. The fermentation can be carried out using solid,semi-solid or liquid nutrient media. If spores such as conidia are used,preference is given to solid or semi-solid nutrient media. The nutrientmedia contain the nutrients suitable and known for the cultivation ofthe respective microorganisms, in particular one or more tometabolizable carbon sources or nitrogen sources and mineral salts. Thefermentation is generally carried out at temperatures between about 3°and about 40° C., preferably between 20° and 35° C. For example, arepresentative fermentation is described in U.S. Pat. No. 5,804,208.

A fermentation process comprises in general the steps of a) incubatingspores such as conidia of a microorganism in or on a nutrition medium(such as agar with further additives such as oatmeal); b) separatingspores such as conidia from the nutrition medium after the incubationtime, (e.g., by shake off the conidia from the medium, centrifuging,filtrating); and optionally c) preparing an emulsion of said isolatedconidia.

The skilled person is well aware how to adapt fermentation to a givenmicroorganism such as fungi or bacteria. In the following, severalfermentations are exemplified in more detail. These examples are notmeant to limit the scope of the present invention.

Bacteria

Bacillus thuringiensis were cultured using media and fermentationtechniques known in the art (see, for example, Rogoff et al., 1969, J.Invertebrate Path. 14: 122-129; Dulmage et al., 1971, J. InvertebratePath. 18: 353-358; Dulmage et al., in Microbial Control of Pests andPlant Diseases, H. D. Burges, ed., Academic Press, N.Y., 1980). Uponcompletion of the fermentation cycle, the supernatant can be recoveredby separating Bacillus thuringiensis spores and crystals from thefermentation broth by means well known in the art, e.g., centrifugationultrafiltration, evaporation, or spray-drying (see also WO 1996001563which is herewith incorporated by reference in its entirety).

The following culturing of Bacillus thuringiensis is e.g. exemplified inU.S. Pat. No. 5,508,032A, 1996:

A subculture of Bacillus thuringiensis isolates can be used to inoculatethe following medium, a peptone, glucose, salts medium: Bacto Peptone7.5 g/l Glucose, 1.0 g/l KH₂PO₄, 3.4 g/l K₂HPO₄, 4.35 g/l salt solution,5.0 m/l CaCl₂ solution, 5.0 m/l salts solution (100 ml) MgSO₄-7H₂O, 2.46g MnSO₄—H₂O, 0.04 g ZnSO₄-7H₂O, 0.28 g FeSO₄-7H₂O, 0.40 g CaCl₂ solution(100 ml), CaCl₂2H₂O, 3.66 g pH 7.2.

The salts solution and CaCl₂ solution were sterilized (e.g.,filter-sterilized) and added to the sterilized (e.g., autoclaved andcooked) broth at the time of inoculation. Flasks were incubated ataround 30° C. on a rotary shaker at 200 rpm for 64 hours. The procedurecan be readily scaled up to large fermentors by procedures well known inthe art. The Bacillus thuringiensis spores and crystals, obtained in thefermentation, can be isolated by procedures well known in the art. Afrequently-used procedure is to subject the harvested fermentation brothto separation techniques, e.g., centrifugation.

the Bacterium Bacillus Firmus

The bacteria Bacillus subtilis is a naturally occurring bacteria foundin soils all over the world. Bacillus subtilis strain QST713 wasisolated in 1995 by AgraQuest Inc. from soil in a California peachorchard. This product is applied to foliage (NYDEC 2001). In contrast,Bacillus subtilis strain GB03 (Kodiak®) was discovered in Australia inthe 1930's and is applied either as a seed treatment or directly tosoil. Neither strain is considered a genetically modified organism(Cornell University: Organic Resource Guide, Material factsheet—Bacillus subtilis)

Isolation of Bacillus subtilis and related strains from soil: To isolatewild Bacillus subtilis strains, e.g., 2 g soil samples were dissolved in2 ml of 10 mM Tris/HCl (pH 7.2) and then boiled at 95° C. for 5 min Fromthese samples, 0.1 ml of each sample was then spread onto LB plates andincubated at 37° C.

Sporulation assay: Bacillus subtilis strains were grown in 26 SG mediumat 37° C. and sporulation was assayed at 24 hours after the end of theexponential phase. The number of spores per ml culture was determined byidentifying the number of heat-resistant colony forming units (80° C.for 10 min) on LB plates.

Bacillus subtilis, strain Marburg, was grown aerobically in heartinfusion broth (Difco Laboratories, Detroit, Mich.) on shaker at about37° C. From an overnight culture 4 drops were inoculated into 70 ml ofpre warmed broth. Growth was measured as optical density at 620 nm Cellswere collected after 3.5-4.5 hours in the exponential phase of growth.Centrifugation was carried out at room temperature for 15 min at 7000 g(The Journal of Cell Biology. Volume 48, 1971•pages 219-224).

Bacillus subtilis is active in temperatures between 7° C. and 45° C.

Bacillus amyloliquefaciens strain FZB42, was originally isolated frominfested soil in Germany (Krebs et al., 1998, Chen et al., 2007).Bacillus amyloliquefaciens strain FZB42 was cultivated in Luria broth(LB—1% w/v peptone, 0.5% w/v yeast extract, 0.5% w/v NaCL) at 30° C.(Journal of Biotechnology 151 (2011) 303-311). The bacteria was grown inLandy medium as described in Koumoutsi et al., 2004. To prepare surfacecultures, the strains were grown in petri dishes containing 1.5% Landyagar for 24 h at 37° C. and stored at room temperature prior toMALDI-TOF-MS analysis. Fermentation in liquid media was carried out inflasks at 30° C. and 180 rpm in a shaker (Journal of Bacteriology,February 2004, p. 1084-1096).

Fungi

The fungus Metarhizium anisopliae, strain DSM 3884, is known fromEP-A-0268177. The production of conidia of Metarhizium anisopliae isexemplified in EP 0794704 B1 (U.S. Pat. No. 5,804,208).

A nutrition medium such as oatmeal agar (e.g., composition: 30 g of oatflakes and 20 g of agar) in a Petri dish was inoculated with, e.g., 3week old conidia of the Metarhizium anisopliae strain DSM 3884. Theincubation time to multiply the conidia is, e.g., 3, 4, 5, or 6 days.The incubation temperature can be around 7° C. to around 40° C., e.g.22° to 25° C. The formed conidia was isolated by, e.g., shaking off theconidia. The conidia can be stirred with 50 ml of water containing 1% ofa non-ionic emulsifier such as an emulsifier based on polyoxy-ethylene(20) sorbitan monolaurate (Tween 20®) until a suspension was obtained inwhich the conidia was present as isolated particles. The conidia titerwas and can be determined using, e.g., a Neubauer chamber. The conidiacan be stored in closed cases under dry conditions, preferably attemperatures between 0° and 25° C.

Paecilomyces lilacinus strain 251 was isolated from infected nematodeeggs in the Philippines, and correctly described taxonomically in 1974.Optimal laboratory growth of Paecilomyces lilacinus strain 251 occurs at21-27° C., and does not grow or survive above 36° C. (U.S. EnvironmentalProtection Agency, P. lilacinus strain 251 Fact sheet). The followingcultivation of Paecilomyces lilacinus is exemplified in PatentApplication WO/1994/025579 (1994):

Paecilomyces lilacinus (Thorn) Samson (CBS 143.75), obtained e.g. fromthe CBS (Central Bureau of Fungal Cultures) in Baarn (The Netherlands),can be maintained on Potato Dextrose Agar (PDA; Difco laboratories) at25° C. A conidial suspension was obtained by adding sterilized water(e.g., 5 ml) to a Petri dish containing sporulating mycelium andscraping the surface with a glass rod. Liquid cultures were obtained byinoculating conidia of the fungus to minimal salt medium or corn flourmedium supplemented with the substrate. The minimal salt medium (MM)consists of 4.56 g H2PO4, 2.77 g KH2 HP04, 0.5 g MgS04.7H20 and 0.5 gKCI/l, pH 6.0. Mycelium can be obtained by centrifuging a, e.g., 6 dayold culture of conidia of Paecilomyces lilacinus. For example, culturescan be grown in a shaking water bath for several days at 30° C. and 125strokes per minute. Culture filtrates were obtained by centrifugingcultures for, e.g., 45 min at 9000 g.

The preparation of Metschnikowia fructicola is exemplified in U.S. Pat.No. 6,994,849:

The yeast species Metschnikowia fructicola was isolated from the surfaceof grape berries (cv. Superior) grown in the central part of Israel. Atvarious stages, individual berries were submersed in sterile distilledwater in 100 ml beakers and shaken vigorously for 2 hours on rotaryshaker at 120 rpm. Aliquots of 100 ml were removed from the wash liquidand plated on PDA (Potato Dextrose Agar; DIFCO Laboratories, U.S.A.)medium. Following 4-5 days of incubation, yeast colonies were pickedrandomly according to colony characteristics (color and morphology) andstreaked individually on fresh medium to obtain biologically purecultures. Cultures were further purified by repeated streaking on PDA.Identification and characterization of the new species was done at theMicrobial Genomics and Bioprocessing center, USDA-ARS, Peoria, Ill.,USA. Metschnikowia fructicola was deposited at the NRRL under the numberY-30752. This deposit has been made in compliance with the terms of theBudapest Treaty.

Metschnikowia fructicola was propagated under aerobic conditions attemperatures ranging from 5° C. to 37° C. Optimal growth temperature isbetween 20° C. and 27° C. The yeast grows in liquid medium (nutrientbroth; Droby et al., 1989) with a neutral pH. The cell density of theyeast generally reached its maximum (stationary stage) growth in 24-48hours. For laboratory and small scale tests growth in Erlenmeyer flaskscontaining the medium and shaken on a rotary shaker was suitable. Forlarge scale and commercial tests, fermentation tanks and industrialgrowth media were preferred. The yeast cells were harvested bycentrifugation using conventional laboratory or industrial centrifuges.

Viruses

Cydia pomonella granulosis viruses (CpGV) which are used in the productsMADEX (Andermatt Biocontrol) and Granupom (Probis GmbH) are depositedsince 2005 at the German Collection of Microorganisms and Cell Cultures(DSMZ). Isolates used for the production of MADEX (AndermattBiocontrol), Granupom (Probis GmbH), VIRGO (SipcamS.p.A.) andCARPOVIRUSINE (Arysta LifeScience S.A.S) were all derived from theMexican isolate originally isolated in 1963 and are not geneticallymodified. (Virus accession number: GV-0001)

The identity of the virus produce can be bioanalytically checked againstthe parent strain by SDSpolyacrylamide-gel electrophoresis of the virusprotein sand by Restriction endonuclease analysis of viral DNA.

Prior to DNA isolation the test item has to be purified. The purifiedCpGV OB pellet is resuspended in 1 ml sterile water and the CpGV OBconcentration is enumerated in the Petroff-Hausser counting chamber. Theconcentration of active Cydia pomonella Granulosis virus (CpGV) isdetermined by means of a quantitative bioassay. The granules (occlusionbodies) of CpGV are counted under the light microscope. The virus titerin the end-use product is adjusted to the requested granules/l(Assessment Report: Cydia pomonella Granulovirus (CpGV)—Mexican Isolate(2007).

CpGV derives from the Mexican isolate of CpGV (Tanada, 1964) and ispropagated in larvae of Cydia pomonella. Infected larvae are homogenizedand centrifuged in 50% sucrose (w/w). The pellet is resuspended and thegranules are purified by, e.g., centrifugation through a linear 50% to60% (w/w) sucrose gradient, generating a virus band which is thenrepeatedly washed in Tris buffer and pelleted to remove residualsucrose. (Journal of general virology (1992), 73, 1621-1626).

Entomopathogenic Nematodes

Nematodes can be reared in liquid culture techniques (see, e.g., U.S.Pat. No. 5,023,183 which is herewith incorporated by reference in itsentirety) and stored, for example, as eggs, larvae in suspensioncultures or in clay powder or adult nematodes, e.g., in clay powder.Nematodes can be held in the refrigerator (2-6° C.) until use for up to4 weeks and can be reactivated by suspension in warm water (>12° C.).

One method to isolate entomopathogenic nematodes from soil is describedby Cairns, 1960, Folia parasitica 47: 315-318, 2000. For soil samples, asieving-decanting method was employed with final isolation of thenematodes from the sieving debris using a Baermann funnel with cottonfilter. For this method, which is commonly applied for the extraction ofplant-parasitic and soil nematodes (Southey 1986), 250 ml soil was used.The nematode suspension was fixed, checked for the presence ofentomopathogenic nematodes using an inverted light microscope, and thenumber of Steinernema specimens was determined Species identificationwas mostly done at high microscopical magnification using morphologicalcharacters of the infectivestage juveniles (Sturhan in Hominick et al.1997, and unpublished).

Entomopathogenic nematodes can be mass-produced by in-vivo or in-vitromethods. Larvae of Galleria mellonella are most commonly used to rearnematodes because of their commercial availability. Several researchers(Dutky et al. 1964, Howell 1979, Lindegren et al. 1993, Flanders et al.1996) have described the methods of nematode infection, inoculation, andharvesting. Using the in-vivo process, yields between 0.5×10⁵-4×10⁵infective juveniles, depending on the nematode species, have beenobtained. During the past few years a distinct cottage industry hasemerged in the USA which utilizes the in-vivo process for nematodemass-production for sale, especially in the home lawn and gardenmarkets. The in-vivo process, however, lacks any economy of scale; thelabor, equipment, and material (insect) costs increase as a linearfunction of production capacity. Perhaps even more important is the lackof improved quality while increasing scale. The in-vivo nematodeproduction is increasingly sensitive to biological variations andcatastrophes as scale increases (Friedman 1990). Several formulationshave been developed for the storage and application of entomopathogenicnematodes. The shelf life of different nematode-based products variesdepending on the formulation, nematode species and temperature. In thesimplest type of formulation, the nematodes are impregnated onto moistcarrier substrates providing substantial interstitial spaces leading toincreased gas exchange. Such carriers include polyether polyurethanesponge, cedar shavings, peat, vermiculite, etc. Nematodes held on thesponge need to be hand-squeezed into water before application, whereasfrom the other carriers they may be applied directly to the soil asmulch (Neotropical Entomology, vol. 30, no. 2, Londrina, June 2001, ISSN1519-566X).

A bioassay to determine nematode viability is described, e.g., in Simser(J. of Nematology 24(3):374-378; 1992). The Nematode viability wasverified by host bioassay. Late instar larvae of the greater wax moth,Galleria mellone, were buried 2.5 cm deep between plants before nematodeapplication (four larvae per replicate), collected after 7 days, placedin petri dishes (9 cm diameter) and held in darkness at ca. 25 C. Insectmortality (>90%) and subsequent nematode propagation with cadaversdemonstrated infectivity of the nematodes. The skilled person is wellaware how to adopt this kind of bioassay to different nematode species.

The preferred application rate of bacteria as biological control agent,in particular of spores of the bacteria (1.26a), namely B. subtilisstrain GBO3, lies in the range of 0.1 to 3 kg/ha.

The preferred application rate of fungi as biological control agent, inparticular the fungi Metarhizium anisopliae strain F 52 lies in therange of 0.1 to 3 kg/ha

The preferred application rate of yeasts as biological control agent, inparticular the yeast Metschnikowia fructicola strain NRRL Y-30752 liesin the range of 0.05 to 8 kg/ha.

The preferred application rate of protozoa, viruses, andentomopathogenic nematodes as biological control agents lies in therange of 0.5 to 10 kg/ha.

It is generally preferred to use or employ the compound (A), compound(B) and the biological control agent (C) selected from bacteria, inparticular spore-forming bacteria, fungi or yeasts, protozoal, viruses,and entomopathogenic nematodes inoculants, botanicals and productsproduced by microorganisms including proteins or secondary metabolites,particularly (C8.1) Harpin on horticultural crops, such as cotton, flax,grapevines, fruit, vegetable, such as Rosaceae sp. (for examplepomaceous fruit, such as apples and pears, but also stone fruit, such asapricots, cherries, almonds and peaches and soft fruit such asstrawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp.,Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp.,Actinidaceae sp., Lauraceae sp., Musaceae sp. (for example banana treesand plantations), Rubiaceae sp. (for example coffee), Theaceae sp.,Sterculiceae sp., Rutaceae sp. (for example lemons, oranges andgrapefruit), Solanaceae sp. (for example tomatoes), Liliaceae sp.,Asteraceae sp. (for example lettuce), Umbelliferae sp., Cruciferae sp.,Chenopodiaceae sp., Cucurbitaceae sp. (for example cucumbers), Alliaceaesp. (for example leek, onions), Papilionaceae sp. (for example peas);major crop plants, such Gramineae sp. (for example maize, lawn, cerealssuch as wheat, rye, rice, barley, oats, millet and triticale), Poaceaesp. (for example sugarcane), Asteraceae sp. (for example sunflowers),Brassicaceae sp. (for example white cabbage, red cabbage, broccoli,cauliflowers, Brussels sprouts, pak Choi, turnip cabbage, garden radish,and also oilseed rape, mustard, horseradish and cress), Fabacae sp. (forexample beans, peas, peanuts), Papilionaceae sp. (for example soyabeans), Solanaceae sp. (for example potatoes), Chenopodiaceae sp. (forexample sugar beet, fodder beet, Swiss chard, beetroot); crop plants andornamental plants in garden and forest; and also in each casegenetically modified varieties of these plants.

Horticultural crops particularly includes carrots, pumpkin, squash,zucchini, potato, sweet corn, onions, ornamentals, medicinal herbs,culinary herbs, tomatoes, spinach, pepper, melon, lettuce, cucumber,celery, beets, cabbage, cauliflower, broccoli, Brussels sprouts, turnipcabbage, kale, radish, rutabaga, turnip, asparagus, bean, pea, apples,raspberry, strawberry, banana, mango, grapes, peaches, pears, guava,pineapple, pomegranate, garlic, capsicum, chili, radish, star fruit,tapioca, walnuts, lemon, mandarin, mangold, mushroom, olive, orange,papaya, paprika, passion fruit, peanuts, pecan nuts, prune, pistachionuts, persimmon, pamplemouse (grapefruit), eggplant, endive, cranberry,gooseberry, hazel nuts, kiwifruit, almonds, amaranth, apricot,artichoke, avocado, blackberry, cashew nut, cherry, clementine, coconut,cantaloupes and includes their harvested goods, such as fruits andvegetables.

It is further generally preferred to use or employ the compound (A),compound (B) and the biological control agent (C) selected frombacteria, in particular spore-forming bacteria, fungi or yeasts,protozoal, viruses, and entomopathogenic nematodes, inoculants,botanicals and products produced by microorganisms including proteins orsecondary metabolites, particularly (C8.1) Harpin on horticultural cropsas well as broad acre crops such as cotton, corn, soybean, cereals,canola, oil seed rape, sugar cane and rice.

Furthermore the invention relates to a method of controlling insects,nematodes or phytopathogens, characterized in that the active compoundcombinations according to the invention are applied to the insects,nematodes or phytopathogens or their habitat.

If not mentioned otherwise the treatment of plants or plant parts (whichincludes seeds and plants emerging from the seed), harvested fruits andvegetables with the compound (A) Fluopyram, (B) a spore-formingbacterium of the genera Bacillus, selected from Bacillus firmus,Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillusamyloliquefaciens, Bacillus subtilis strain GB03, Bacillus subtilisstrain QST713, and (C) a biological control agent, in particularbacteria, fungi or yeasts, protozoa, viruses, entomopathogenicnematodes, inoculants, botanicals and products produced bymicroorganisms including proteins or secondary metabolites, particularly(C8.1) Harpin is carried out directly or by action on theirsurroundings, habitat or storage space using customary treatmentmethods, for example dipping, spraying, atomizing, irrigating,evaporating, dusting, fogging, broadcasting, foaming, painting,spreading-on, watering (drenching), drip irrigating. It is furthermorepossible to apply compound (A) Fluopyram, (B) a spore-forming bacteriumof the genera Bacillus, selected from Bacillus firmus, Bacillus firmusCNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillusamyloliquefaciens, Bacillus subtilis strain GB03, Bacillus subtilisstrain QST713, and (C) a biological control agent, in particularbacteria, fungi or yeasts, protozoa, viruses, entomopathogenicnematodes, inoculants, botanicals and products produced bymicroorganisms including proteins or secondary metabolites, particularly(C8.1) Harpin as solo-formulation or combined-formulations by theultra-low volume method, or to inject the compound (A) Fluopyram, (B) aspore-forming bacterium of the genera Bacillus, selected from Bacillusfirmus, Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis,Bacillus amyloliquefaciens, Bacillus subtilis strain GB03, Bacillussubtilis strain QST713, and (C) a biological control agent, inparticular bacteria, fungi or yeasts, protozoa, viruses,entomopathogenic nematodes, inoculants, botanicals and products producedby microorganisms including proteins or secondary metabolites,particularly (C8.1) Harpin as a composition or as sole-formulations intothe soil (in-furrow).

Compositions

The present invention furthermore relates to compositions for reducingoverall damage of plants and plant parts as well as losses in harvestedfruits or vegetables caused by insects, nematodes or phytopathogens andwhich have fungicidal or nematicidal or insecticidal activity includingany combination of the three activities comprising the active compoundcombinations according to the invention. Preferably, the compositionsare fungicidal or nematicidal or insecticidal (including any combinationof the three) compositions comprising agriculturally suitableauxiliaries, solvents, carriers, surfactants or extenders.

For the sake of clearness, a combination means a physical combination of(A) Fluopyram, (B) a spore-forming bacterium of the genera Bacillus,selected from Bacillus firmus, Bacillus firmus CNCM I-1582, Bacilluscereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillus subtilisstrain GB03, Bacillus subtilis strain QST713, and (C) at least onebiological control agent, in particular bacteria, fungi or yeasts,protozoa, viruses, entomopathogenic nematodes, botanicals and productsproduced by microorganisms including proteins or secondary metabolites,particularly (C8.1) Harpin, whereas a composition means a composition ofthe combination together with the above mentioned agriculturallysuitable auxiliaries, solvents, carriers, surfactants or extenders, in aform as suitable for agrochemical application.

According to the invention, carrier is to be understood as meaning anatural or synthetic, organic or inorganic substance which is mixed orcombined with the active compounds for better applicability, inparticular for application to plants or plant parts or seeds. Thecarrier, which may be solid or liquid, is generally inert and should besuitable for use in agriculture.

Suitable solid or liquid carriers are: for example ammonium salts andnatural ground minerals, such as kaolins, clays, talc, chalk, quartz,attapulgite, montmorillonite or diatomaceous earth, and ground syntheticminerals, such as finely divided silica, alumina and natural orsynthetic silicates, resins, waxes, solid fertilizers, water, alcohols,especially butanol, organic solvents, mineral oils and vegetable oils,and also derivatives thereof. It is also possible to use mixtures ofsuch carriers. Solid carriers suitable for granules are: for examplecrushed and fractionated natural minerals, such as calcite, marble,pumice, sepiolite, dolomite, and also synthetic granules of inorganicand organic meals and also granules of organic material, such assawdust, coconut shells, maize cobs and tobacco stalks.

Suitable liquefied gaseous extenders or carriers are liquids which aregaseous at ambient temperature and under atmospheric pressure, forexample aerosol propellants, such as butane, propane, nitrogen andcarbon dioxide.

Tackifiers, such as carboxymethylcellulose and natural and syntheticpolymers in the form of powders, granules and latices, such as gumarabic, polyvinyl alcohol, polyvinyl acetate, or else naturalphospholipids, such as cephalins and lecithins and syntheticphospholipids can be used in the formulations. Other possible additivesare mineral and vegetable oils and waxes, optionally modified.

If the extender used is water, it is also possible for example, to useorganic solvents as auxiliary solvents. Suitable liquid solvents areessentially: aromatic compounds, such as xylene, toluene oralkylnaphthalenes, chlorinated aromatic compounds or chlorinatedaliphatic hydrocarbons, such as chlorobenzenes, chloroethylenes ormethylene chloride, aliphatic hydrocarbons, such as cyclohexane orparaffins, for example mineral oil fractions, mineral and vegetableoils, alcohols, such as butanol or glycol, and also ethers and estersthereof, ketones, such as acetone, methyl ethyl ketone, methyl isobutylketone or cyclohexanone, strongly polar solvents, such asdimethylformamide and dimethyl sulphoxide, and also water.

The compositions according to the invention may comprise additionalfurther components, such as, for example, surfactants. Suitablesurfactants are emulsifiers, dispersants or wetting agents having ionicor nonionic properties, or mixtures of these surfactants. Examples ofthese are salts of polyacrylic acid, salts of lignosulphonic acid, saltsof phenolsulphonic acid or naphthalenesulphonic acid, polycondensates ofethylene oxide with fatty alcohols or with fatty acids or with fattyamines, substituted phenols (preferably alkylphenols or arylphenols),salts of sulphosuccinic esters, taurine derivatives (preferably alkyltaurates), phosphoric esters of polyethoxylated alcohols or phenols,fatty esters of polyols, and derivatives of the compounds containingsulphates, sulphonates and phosphates. The presence of a surfactant isrequired if one of the active compounds or one of the inert carriers isinsoluble in water and when the application takes place in water. Theproportion of surfactants is between 5 and 40% by weight of thecomposition according to the invention.

It is possible to use colorants such as inorganic pigments, for exampleiron oxide, titanium oxide, Prussian blue, and organic dyes, such asalizarin dyes, azo dyes and metal phthalocyanine dyes, and tracenutrients, such as salts of iron, manganese, boron, copper, cobalt,molybdenum and zinc.

If appropriate, other additional components may also be present, forexample protective colloids, binders, adhesives, thickeners, thixotropicsubstances, penetrants, stabilizers, sequestering agents, complexformers. In general, the active compounds can be combined with any solidor liquid additive customarily used for formulation purposes.

In general, the compositions according to the invention comprise between0.01 and 99% by weight, 0.05 and 98% by weight, preferable between 0.1and 95% by weight, particularly preferred between 0.5 and 90% by weightof the active compound combination according to the invention, veryparticularly preferable between 10 and 70% by weight.

The active compound combinations or compositions according to theinvention can be used as such or, depending on their respective physicalor chemical properties, in the form of their formulations or the useforms prepared therefrom, such as aerosols, capsule suspensions,cold-fogging concentrates, warm-fogging concentrates, encapsulatedgranules, fine granules, flowable concentrates for the treatment ofseed, ready-to-use solutions, dustable powders, emulsifiableconcentrates, oil-in-water emulsions, water-in-oil emulsions,macrogranules, microgranules, oil-dispersible powders, oil-miscibleflowable concentrates, oil-miscible liquids, foams, pastes,pesticide-coated seed, suspension concentrates, suspoemulsionconcentrates, soluble concentrates, suspensions, wettable powders,soluble powders, dusts and granules, water-soluble granules or tablets,water-soluble powders for the treatment of seed, wettable powders,natural products and synthetic substances impregnated with activecompound, and also microencapsulations in polymeric substances and incoating materials for seed, and also ULV cold-fogging and warm-foggingformulations.

The formulations mentioned can be prepared in a manner known per se, forexample by mixing the active compounds or the active compoundcombinations with at least one additive. Suitable additives are allcustomary formulation auxiliaries, such as, for example, organicsolvents, extenders, solvents or diluents, solid carriers and fillers,surfactants (such as adjuvants, emulsifiers, dispersants, protectivecolloids, wetting agents and tackifiers), dispersants or binders orfixatives, preservatives, dyes and pigments, defoamers, inorganic andorganic thickeners, water repellents, if appropriate siccatives and UVstabilizers, gibberellins and also water and further processingauxiliaries. Depending on the formulation type to be prepared in eachcase, further processing steps such as, for example, wet grinding, drygrinding or granulation may be required.

The compositions according to the invention do not only compriseready-to-use compositions which can be applied with suitable apparatusto the plant or the seed, but also commercial concentrates which have tobe diluted with water prior to use.

The active compound combinations according to the invention can bepresent in (commercial) formulations and in the use forms prepared fromthese formulations as a mixture with other (known) active compounds,such as insecticides, attractants, sterilants, bactericides, acaricides,nematicides, fungicides, growth regulators, herbicides, fertilizers,safeners and Semiochemicals.

The treatment according to the invention of the plants and plant partswith the active compounds or compositions is carried out directly or byaction on their surroundings, habitat or storage space using customarytreatment methods, for example by dipping, spraying, atomizing,irrigating, evaporating, dusting, fogging, broadcasting, foaming,painting, spreading-on, watering (drenching), drip irrigating and, inthe case of propagation material, in particular in the case of seeds,furthermore as a powder for dry seed treatment, a solution for seedtreatment, a water-soluble powder for slurry treatment, by incrusting,by coating with one or more layers, etc. It is furthermore possible toapply the active compound combination by the ultra-low volume method, orto inject the active compound combination or the active compoundcombination itself into the soil.

Seed Treatment

Moreover the invention is directed to a method for protecting seedscomprising the step of simultaneously or sequentially applying acompound (A) Fluopyram, (B) a spore-forming bacterium of the generaBacillus, selected from Bacillus firmus, Bacillus firmus CNCM I-1582,Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillussubtilis strain GB03, Bacillus subtilis strain QST713, and (C) abiological control agent, in particular bacteria, fungi or yeasts,protozoa, viruses, entomopathogenic nematodes, inoculants, botanicalsand products produced by microorganisms including proteins or secondarymetabolites, particularly (C8.1) Harpin on a seed or a plant emergingfrom the seed. The method is further called “seed treatment”.

Using compound (A) Fluopyram, (B) a spore-forming bacterium of thegenera Bacillus, selected from Bacillus firmus, Bacillus firmus CNCMI-1582, Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens,Bacillus subtilis strain GB03, Bacillus subtilis strain QST713, and (C)a biological control agent, in particular bacteria, fungi or yeasts,protozoa, viruses, entomopathogenic nematodes, inoculants, botanicalsand products produced by microorganisms including proteins or secondarymetabolites, particularly (C8.1) Harpin as a combination is particularlysuitable for treating seed. A large part of the damage to crop plantscaused by harmful agricultural insects, nematodes or phytopathogens istriggered by an infection of the seed during storage or after sowing aswell as during and after germination of the plant. This phase isparticularly critical since the roots and shoots of the growing plantare particularly sensitive, and even small damage may result in a weakplant (unhealthy plant), reduced yield and even in the death of theplant.

The control of insects, nematodes or phytopathogens by treating the seedof plants has been known for a long time and is the subject ofcontinuous improvements. However, the treatment of seed entails a seriesof problems which cannot always be solved in a satisfactory manner.Thus, it is desirable to develop methods for protecting the seed and thegerminating plant which dispense with the additional application of cropprotection agents after sowing or after the emergence of the plants orwhich at least considerably reduce additional application. It isfurthermore desirable to optimize the amount of agrochemicals employedin such a way as to provide maximum protection for the seed and thegerminating plant from attack by agricultural pests, but withoutdamaging the plant itself by the active compound employed. Inparticular, methods for the treatment of seed should also take intoconsideration the intrinsic insecticidal or fungicidal or nematicidalproperties of plants in order to achieve optimum protection of the seedand the germinating plant with a minimum of agrochemicals beingemployed.

The use or the method to use a compound (A) Fluopyram, (B) aspore-forming bacterium of the genera Bacillus, selected from Bacillusfirmus, Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis,Bacillus amyloliquefaciens, Bacillus subtilis strain GB03, Bacillussubtilis strain QST713, and (C) a biological control agent, inparticular bacteria, fungi or yeasts, protozoa, viruses,entomopathogenic nematodes, inoculants, botanicals and products producedby microorganisms including proteins or secondary metabolites,particularly (C8.1) Harpin simultaneously or sequentially includes thefollowing application methods, namely both before mentioned componentsmay be formulated into a single, stable composition with anagriculturally acceptable shelf life (so called “solo-formulation”), orbeing combined before or at the time of use (so called“combined-formulations”),

The invention furthermore comprises a method for treating seed. Theinvention furthermore relates to seed treated according to one of themethods described in the preceding paragraphs. In the case of seedtreatment, the treatment can be carried out by applying the compound (A)Fluopyram, (B) a spore-forming bacterium of the genera Bacillus,selected from Bacillus firmus, Bacillus firmus CNCM I-1582, Bacilluscereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillus subtilisstrain GB03, Bacillus subtilis strain QST713, and (C) a biologicalcontrol agent, in particular bacteria, fungi or yeasts, protozoa,viruses, entomopathogenic nematodes, inoculants, botanicals and productsproduced by microorganisms including proteins or secondary metabolites,particularly (C8.1) Harpin as a solution, a powder (for dry seedtreatment), a water-soluble powder (for slurry seed treatment), or byincrusting, by coating with one or more layers containing the compound(A) Fluopyram, (B) a spore-forming bacterium of the genera Bacillus,selected from Bacillus firmus, Bacillus firmus CNCM I-1582, Bacilluscereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillus subtilisstrain GB03, Bacillus subtilis strain QST713, and (C) a biologicalcontrol agent, in particular bacteria, fungi or yeasts, protozoa,viruses, entomopathogenic nematodes, inoculants, botanicals and productsproduced by microorganisms including proteins or secondary metabolites,particularly (C8.1) Harpin.

The active compound combinations or compositions according to theinvention are especially suitable for treating seed. A large part of thedamage to crop plants caused by harmful organisms is triggered by aninfection of the seed during storage or after sowing as well as duringand after germination of the plant. This phase is particularly criticalsince the roots and shoots of the growing plant are particularlysensitive, and even small damage may result in the death of the plant.Accordingly, there is great interest in protecting the seed and thegerminating plant by using appropriate compositions.

The control of phytopathogenic fungi by treating the seed of plants hasbeen known for a long time and is the subject of continuousimprovements. However, the treatment of seed entails a series ofproblems which cannot always be solved in a satisfactory manner. Thus,it is desirable to develop methods for protecting the seed and thegerminating plant which dispense with the additional application of cropprotection agents after sowing or after the emergence of the plants orwhich at least considerably reduce additional application. It isfurthermore desirable to optimize the amount of active compoundcombination employed in such a way as to provide maximum protection forthe seed and the germinating plant from attack by insects, nematodes orphytopathogens, but without damaging the plant itself by the activecompound combination employed. In particular, methods for the treatmentof seed should also take into consideration the intrinsic fungicidal orinsecticidal or nematicidal properties of transgenic plants in order toachieve optimum protection of the seed and the germinating plant with aminimum of crop protection agents being employed.

Accordingly, the present invention also relates in particular to amethod for protecting seed and germinating plants against attack byinsects, nematodes or phytopathogens by treating the seed with acomposition according to the invention. The invention also relates tothe use of the compositions according to the invention for treating seedfor protecting the seed and the germinating plant against insects,nematodes or phytopathogens. Furthermore, the invention relates to seedtreated with a composition according to the invention for protectionagainst insects, nematodes or phytopathogens.

The control of insects, nematodes or phytopathogens which damage plantspost-emergence is carried out primarily by treating the soil and theabove-ground parts of plants with crop protection compositions. Owing tothe concerns regarding a possible impact of the crop protectioncomposition on the environment and the health of humans and animals,there are efforts to reduce the amount of active compound combinationapplied.

One of the advantages of the present invention is that, because of theparticular systemic properties of the compositions according to theinvention, treatment of the seed with these compositions not onlyprotects the seed itself, but also the resulting plants after emergence,from insects, nematodes or phytopathogens. In this manner, the immediatetreatment of the crop at the time of sowing or shortly thereafter can bedispensed with.

It is also considered to be advantageous that the active compoundcombinations or compositions according to the invention can be used inparticular also for transgenic seed where the plant growing from thisseed is capable of expressing a protein which acts against insects,nematodes or phytopathogens. By treating such seed with the activecompound combinations or compositions according to the invention, evenby the expression of the, for example, insecticidal protein, certaininsects, nematodes or phytopathogens may be controlled. Surprisingly, afurther synergistic effect may be observed here, which additionallyincreases the effectiveness of the protection against attack by insects,nematodes or phytopathogens.

The compositions according to the invention are suitable for protectingseed of any plant variety employed in agriculture, in the greenhouse, inforests or in horticulture or viticulture. In particular, this takes theform of seed of cereals (such as wheat, barley, rye, triticale, millet,oats), maize (corn), cotton, soya bean, rice, potatoes, sunflowers,beans, coffee, beets (e.g. sugar beets and fodder beets), peanuts,oilseed rape, poppies, olives, coconuts, cacao, sugar cane, sorghum,tobacco, vegetables (such as tomatoes, cucumbers, onions and lettuce),lawn and ornamental plants (also see below).

As also described further below, the treatment of transgenic seed withthe active compound combinations or compositions according to theinvention is of particular importance. This refers to the seed of plantscontaining at least one heterologous gene which allows the expression ofa polypeptide or protein having insecticidal properties. Theheterologous gene in transgenic seed can originate, for example, frommicroorganisms of the species Bacillus, Rhizobium, Pseudomonas,Serratia, Trichoderma, Clavibacter, Glomus or Gliocladium. Preferably,this heterologous gene is from Bacillus sp., the gene product havingactivity against the European corn borer or the Western corn rootworm.Particularly preferably, the heterologous gene originates from Bacillusthuringiensis.

In the context of the present invention, the active compoundcombinations or compositions according to the invention are applied ontheir own or in a suitable formulation to the seed. Preferably, the seedis treated in a state in which it is sufficiently stable so that thetreatment does not cause any damage. In general, treatment of the seedmay take place at any point in time between harvesting and sowing.Usually, the seed used is separated from the plant and freed from cobs,shells, stalks, coats, hairs or the flesh of the fruits. Thus, it ispossible to use, for example, seed which has been harvested, cleaned anddried to a moisture content of less than 15% by weight. Alternatively,it is also possible to use seed which, after drying, has been treated,for example, with water and then dried again.

When treating the seed, care must generally be taken that the amount ofthe composition according to the invention applied to the seed or theamount of further additives is chosen in such a way that the germinationof the seed is not adversely affected, or that the resulting plant isnot damaged. This must be borne in mind in particular in the case ofactive compounds which may have phytotoxic effects at certainapplication rates.

The compositions according to the invention can be applied directly,that is to say without comprising further components and without havingbeen diluted. In general, it is preferable to apply the compositions tothe seed in the form of a suitable formulation. Suitable formulationsand methods for the treatment of seed are known to the person skilled inthe art and are described, for example, in the following documents: U.S.Pat. No. 4,272,417, U.S. Pat. No. 4,245,432, U.S. Pat. No. 4,808,430,U.S. Pat. No. 5,876,739, US 2003/0176428 A1, WO 2002/080675, WO2002/028186.

The active compound combinations which can be used according to theinvention can be converted into customary seed dressing formulations,such as solutions, emulsions, suspensions, powders, foams, slurries orother coating materials for seed, and also ULV formulations.

These formulations are prepared in a known manner by mixing the activecompounds or active compound combinations with customary additives, suchas, for example, customary extenders and also solvents or diluents,colorants, wetting agents, dispersants, emulsifiers, defoamers,preservatives, secondary thickeners, adhesives, gibberellins and wateras well.

Suitable colorants that may be present in the seed dressing formulationswhich can be used according to the invention include all colorantscustomary for such purposes. Use may be made both of pigments, ofsparing solubility in water, and of dyes, which are soluble in water.Examples that may be mentioned include the colorants known under thedesignations Rhodamine B, C.I. Pigment Red 112, and C.I. Solvent Red 1.

Suitable wetting agents that may be present in the seed dressingformulations which can be used according to the invention include allsubstances which promote wetting and are customary in the formulation ofactive agrochemical substances. With preference it is possible to usealkylnaphthalene-sulphonates, such as diisopropyl- ordiisobutylnaphthalene-sulphonates.

Suitable dispersants or emulsifiers that may be present in the seeddressing formulations which can be used according to the inventioninclude all nonionic, anionic, and cationic dispersants which arecustomary in the formulation of active agrochemical substances. Withpreference, it is possible to use nonionic or anionic dispersants ormixtures of nonionic or anionic dispersants. Particularly suitablenonionic dispersants are ethylene oxide-propylene oxide block polymers,alkylphenol polyglycol ethers, and tristyrylphenol polyglycol ethers,and their phosphated or sulphated derivatives. Particularly suitableanionic dispersants are lignosulphonates, polyacrylic salts, andarylsulphonate-formaldehyde condensates.

Defoamers that may be present in the seed dressing formulations to beused according to the invention indude all foam-inhibiting compoundswhich are customary in the formulation of agrochemically activecompounds. Preference is given to using silicone defoamers, magnesiumstearate, silicone emulsions, long-chain alcohols, fatty acids and theirsalts and also organofluorine compounds and mixtures thereof

Preservatives that may be present in the seed dressing formulations tobe used according to the invention include all compounds which can beused for such purposes in agrochemical compositions. By way of example,mention may be made of dichlorophen and benzyl alcohol hemiformal.

Secondary thickeners that may be present in the seed dressingformulations to be used according to the invention include all compoundswhich can be used for such purposes in agrochemical compositions.Preference is given to cellulose derivatives, acrylic acid derivatives,polysaccharides, such as xanthan gum or Veegum, modified clays,phyllosilicates, such as attapulgite and bentonite, and also finelydivided silicic acids.

Suitable adhesives that may be present in the seed dressing formulationsto be used according to the invention include all customary binderswhich can be used in seed dressings. Polyvinylpyrrolidone, polyvinylacetate, polyvinyl alcohol and tylose may be mentioned as beingpreferred.

Suitable gibberellins that may be present in the seed dressingformulations to be used according to the invention are preferably thegibberellins A1, A3 (=gibberellic acid), A4 and A7; particularpreference is given to using gibberellic acid. The gibberellins areknown (cf. R. Wegler “Chemie der Pflanzenschutz- andSchädlingsbekämpfungsmittel” [Chemistry of Crop Protection Agents andPesticides], Vol. 2, Springer Verlag, 1970, pp. 401-412).

The seed dressing formulations which can be used according to theinvention may be used directly or after dilution with water beforehandto treat seed of any of a very wide variety of types. The seed dressingformulations which can be used according to the invention or theirdilute preparations may also be used to dress seed of transgenic plants.In this context, synergistic effects may also arise in interaction withthe substances formed by expression.

Suitable mixing equipment for treating seed with the seed dressingformulations which can be used according to the invention or thepreparations prepared from them by adding water includes all mixingequipment which can commonly be used for dressing. The specificprocedure adopted when dressing comprises introducing the seed into amixer, adding the particular desired amount of seed dressingformulation, either as it is or following dilution with waterbeforehand, and carrying out mixing until the formulation is uniformlydistributed on the seed. Optionally, a drying operation follows.

The active compounds or compositions according to the invention havestrong bactericidal or fungicidal or insecticidal or nematicidalactivity and can be used for controlling insects, nematodes orphytopathogens in crop protection and material protection.

In crop protection, fungicides can be used for controllingphytopathogens like Plasmodiophoromycetes, Oomycetes, Chytridiomycetes,Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes.

In crop protection, bactericides can be used for controllingphytopathogens Pseudomonadaceae, Rhizobiaceae, Enterobacteriaceae,Corynebacteriaceae and Streptomycetaceae.

The fungicidal or insecticidal or nematicidal compositions according tothe invention can be used for the curative or protective control ofinsects, nematodes or phytopathogens. Accordingly, the invention alsorelates to curative and protective methods for controlling insects,nematodes or phytopathogens using the active compound combinations orcompositions according to the invention, which are applied to the seed,the plant or plant parts, the fruit or the soil in which the plantsgrow. Preference is given to application onto the plant or the plantparts, the fruits or the soil in which the plants grow.

The compositions according to the invention for controlling insects,nematodes or phytopathogens in crop protection comprise an active, butnon-phytotoxic amount of the compounds according to the invention.“Active, but non-phytotoxic amount” shall mean an amount of thecomposition according to the invention which is sufficient to control orto completely kill the plant disease caused by insects, nematodes orphytopathogens, which amount at the same time does not exhibitnoteworthy symptoms of phytotoxicity. These application rates generallymay be varied in a broader range, which rate depends on several factors,e.g. the insects, nematodes or phytopathogens, the plant or crop, theclimatic conditions and the ingredients of the composition according tothe invention.

The fact that the active compounds or active compound combinations, atthe concentrations required for the controlling of plant diseases, arewell tolerated by plants permits the treatment of aerial plant parts, ofvegetative propagation material and seed, and of the soil.

According to the invention, it is possible to treat all plants and partsof plants. Plants are to be understood here as meaning all plants andplant populations, such as wanted and unwanted wild plants or cropplants (including naturally occurring crop plants). Crop plants can beplants which can be obtained by conventional breeding and optimizationmethods or by biotechnological and genetic engineering methods orcombinations of these methods, including the transgenic plants andincluding plant cultivars which can or cannot be protected by plantvariety protection rights. Parts of plants are to be understood asmeaning all above-ground and below-ground parts and organs of theplants, such as shoot, leaf, flower and root, examples which may bementioned being leaves, needles, stems, trunks, flowers, fruit bodies,fruits and seeds and also roots, tubers and rhizomes. Plant parts alsoinclude harvested material and vegetative and generative propagationmaterial, for example seedlings, tubers, rhizomes, bulbs, cuttings andseeds. Preference is given to the treatment of the plants and theabove-ground and below-ground parts and organs of the plants, such asshoot, leaf, flower and root, examples which may be mentioned beingleaves, needles, stems, trunks, flowers, and fruits.

The active compounds or active compound combinations of the invention,in combination with good plant tolerance and favourable toxicity towarm-blooded animals and being tolerated well by the environment, aresuitable for protecting plants and plant organs, for increasing theharvest yields, for improving the quality of the harvested material.They may be preferably employed as crop protection agents. They areactive against normally sensitive and resistant species and against allor some stages of development.

As already mentioned above, it is possible to treat all plants and theirparts according to the invention. In a preferred embodiment, wild plantspecies and plant cultivars, or those obtained by conventionalbiological breeding methods, such as crossing or protoplast fusion, andparts thereof, are treated. In a further preferred embodiment,transgenic plants and plant cultivars obtained by genetic engineeringmethods, if appropriate in combination with conventional methods(genetically modified organisms), and parts thereof are treated. Theterms “parts”, “parts of plants” and “plant parts” have been explainedabove. Particularly preferably, plants of the plant cultivars which arein each case commercially available or in use are treated according tothe invention. Plant cultivars are to be understood as meaning plantshaving novel properties (“traits”) which have been obtained byconventional breeding, by mutagenesis or by recombinant DNA techniques.These can be cultivars, bio- or genotypes.

The method of treatment according to the invention is used in thetreatment of genetically modified organisms (GMOs), e.g. plants orseeds. Genetically modified plants (or transgenic plants) are plants ofwhich a heterologous gene has been stably integrated into the genome.The expression “heterologous gene” essentially means a gene which isprovided or assembled outside the plant and when introduced in thenuclear, chloroplastic or mitochondrial genome gives the transformedplant new or improved agronomic or other properties by expressing aprotein or polypeptide of interest or by down regulating or silencingother gene(s) which are present in the plant (using for example,antisense technology, co-suppression technology or RNAinterference—RNAi—technology). A heterologous gene that is located inthe genome is also called a transgene. A transgene that is defined byits particular location in the plant genome is called a transformationor transgenic event.

Depending on the plant species or plant cultivars, their location andgrowth conditions (soils, climate, vegetation period, diet), thetreatment according to the invention may also result in super-additive(“synergistic”) effects. Thus, for example, reduced application rates ora widening of the activity spectrum or an increase in the activity ofthe active compound combinations and compositions which can be usedaccording to the invention, better plant growth, increased tolerance tohigh or low temperatures, increased tolerance to drought or to water orsoil salt content, increased flowering performance, easier harvesting,accelerated maturation, higher harvest yields, bigger fruits, largerplant height, greener leaf color, earlier flowering, higher quality or ahigher nutritional value of the harvested products, higher sugarconcentration within the fruits, better storage stability orprocessability of the harvested products are possible, which exceed theeffects which were actually to be expected.

At certain application rates, the active compound combinations accordingto the invention may also have a strengthening effect in plants.Accordingly, they are also suitable for mobilizing the defense system ofthe plant against attack by unwanted phytopathogenic fungi and/ormicroorganisms or viruses. This may, if appropriate, be one of thereasons of the enhanced activity of the combinations according to theinvention, for example against fungi. Plant-strengthening(resistance-inducing) substances are to be understood as meaning, in thepresent context, those substances or combinations of substances whichare capable of stimulating the defense system of plants in such a waythat, when subsequently inoculated with unwanted phytopathogenic fungior microorganisms or viruses, the treated plants display a substantialdegree of resistance to these phytopathogenic fungi or microorganisms orviruses, Thus, the substances according to the invention can be employedfor protecting plants against attack by the abovementionedphytopathogens within a certain period of time after the treatment. Theperiod of time within which protection is effected generally extendsfrom 1 to 10 days, preferably 1 to 7 days, after the treatment of theplants with the active compounds or active compound combinations.

Plants and plant cultivars which are preferably to be treated accordingto the invention include all plants which have genetic material whichimpart particularly advantageous, useful traits to these plants (whetherobtained by breeding or biotechnological means).

Plants and plant cultivars which are also preferably to be treatedaccording to the invention are resistant against one or more bioticstresses, i.e. said plants show a better defense against animal andmicrobial pests, such as against nematodes, insects, mites,phytopathogenic fungi, bacteria, viruses or viroids.

Plants and plant cultivars which may also be treated according to theinvention are those plants which are resistant to one or more abioticstresses. Abiotic stress conditions may include, for example, drought,cold temperature exposure, heat exposure, osmotic stress, flooding,increased soil salinity, increased mineral exposure, ozon exposure, highlight exposure, limited availability of nitrogen nutrients, limitedavailability of phosphorus nutrients, shade avoidance.

Plants and plant cultivars which may also be treated according to theinvention, are those plants characterized by enhanced yieldcharacteristics. Increased yield in said plants can be the result of,for example, improved plant physiology, growth and development, such aswater use efficiency, water retention efficiency, improved nitrogen use,enhanced carbon assimilation, improved photosynthesis, increasedgermination efficiency and accelerated maturation. Yield can furthermorebe affected by improved plant architecture (under stress and non-stressconditions), including but not limited to, early flowering, floweringcontrol for hybrid seed production, seedling vigor, plant size,internode number and distance, root growth, seed size, fruit size, podsize, pod or ear number, seed number per pod or ear, seed mass, enhancedseed filling, reduced seed dispersal, reduced pod dehiscence and lodgingresistance. Further yield traits include seed composition, such ascarbohydrate content, protein content, oil content and composition,nutritional value, reduction in anti-nutritional compounds, improvedprocessability and better storage stability.

Plants that may be treated according to the invention are hybrid plantsthat already express the characteristic of heterosis or hybrid vigorwhich results in generally higher yield, vigor, health and resistancetowards biotic and abiotic stress factors. Such plants are typicallymade by crossing an inbred male-sterile parent line (the female parent)with another inbred male-fertile parent line (the male parent). Hybridseed is typically harvested from the male sterile plants and sold togrowers. Male sterile plants can sometimes (e.g. in corn) be produced bydetasseling, i e the mechanical removal of the male reproductive organs(or males flowers) but, more typically, male sterility is the result ofgenetic determinants in the plant genome. In that case, and especiallywhen seed is the desired product to be harvested from the hybrid plantsit is typically useful to ensure that male fertility in the hybridplants is fully restored. This can be accomplished by ensuring that themale parents have appropriate fertility restorer genes which are capableof restoring the male fertility in hybrid plants that contain thegenetic determinants responsible for male-sterility. Geneticdeterminants for male sterility may be located in the cytoplasm.Examples of cytoplasmic male sterility (CMS) were for instance describedin Brassica species. However, genetic determinants for male sterilitycan also be located in the nuclear genome. Male sterile plants can alsobe obtained by plant biotechnology methods such as genetic engineering.A particularly useful means of obtaining male-sterile plants isdescribed in WO 89/10396 in which, for example, a ribonuclease such asbarnase is selectively expressed in the tapetum cells in the stamens.Fertility can then be restored by expression in the tapetum cells of aribonuclease inhibitor such as barstar.

Plants or plant cultivars (obtained by plant biotechnology methods suchas genetic engineering) which may be treated according to the inventionare herbicide-tolerant plants, i.e. plants made tolerant to one or moregiven herbicides. Such plants can be obtained either by genetictransformation, or by selection of plants containing a mutationimparting such herbicide tolerance.

Herbicide-tolerant plants are for example glyphosate-tolerant plants,i.e. plants made tolerant to the herbicide glyphosate or salts thereof.Plants can be made tolerant to glyphosate through different means. Forexample, glyphosate-tolerant plants can be obtained by transforming theplant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphatesynthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutantCT7) of the bacterium Salmonella typhimurium, the CP4 gene of thebacterium Agrobacterium sp, the genes encoding a Petunia EPSPS, a TomatoEPSPS, or an Eleusine EPSPS. It can also be a mutated EPSPS.Glyphosate-tolerant plants can also be obtained by expressing a genethat encodes a glyphosate oxidoreductase enzyme. Glyphosate-tolerantplants can also be obtained by expressing a gene that encodes aglyphosate acetyl transferase enzyme. Glyphosate-tolerant plants canalso be obtained by selecting plants containing naturally-occurringmutations of the above-mentioned genes.

Other herbicide resistant plants are for example plants that are madetolerant to herbicides inhibiting the enzyme glutamine synthase, such asbialaphos, phosphinothricin or glufosinate. Such plants can be obtainedby expressing an enzyme detoxifying the herbicide or a mutant glutaminesynthase enzyme that is resistant to inhibition. One such efficientdetoxifying enzyme is an enzyme encoding a phosphinothricinacetyltransferase (such as the bar or pat protein from Streptomycesspecies). Plants expressing an exogenous phosphinothricinacetyltransferase are also described.

Further herbicide-tolerant plants are also plants that are made tolerantto the herbicides inhibiting the enzyme hydroxyphenylpyruvatedioxygenase(HPPD). Hydroxyphenylpyruvatedioxygenases are enzymes that catalyze thereaction in which para-hydroxyphenylpyruvate (HPP) is transformed intohomogentisate. Plants tolerant to HPPD-inhibitors can be transformedwith a gene encoding a naturally-occurring resistant HPPD enzyme, or agene encoding a mutated HPPD enzyme. Tolerance to HPPD-inhibitors canalso be obtained by transforming plants with genes encoding certainenzymes enabling the formation of homogentisate despite the inhibitionof the native HPPD enzyme by the HPPD-inhibitor. Tolerance of plants toHPPD inhibitors can also be improved by transforming plants with a geneencoding an enzyme prephenate dehydrogenase in addition to a geneencoding an HPPD-tolerant enzyme.

Still further herbicide resistant plants are plants that are madetolerant to acetolactate synthase (ALS) inhibitors. Known ALS-inhibitorsinclude, for example, sulfonylurea, imidazolinone, triazolopyrimidines,pyrimidinyoxy(thio)benzoates, or sulfonylaminocarbonyltriazolinoneherbicides. Different mutations in the ALS enzyme (also known asacetohydroxyacid synthase, AHAS) are known to confer tolerance todifferent herbicides and groups of herbicides. The production ofsulfonylurea-tolerant plants and imidazolinone-tolerant plants isdescribed in WO 1996/033270. Other imidazolinone-tolerant plants arealso described. Further sulfonylurea- and imidazolinone-tolerant plantsare also described in for example WO 2007/024782.

Other plants tolerant to imidazolinone or sulfonylurea can be obtainedby induced mutagenesis, selection in cell cultures in the presence ofthe herbicide or mutation breeding as described for example forsoybeans, for rice, for sugar beet, for lettuce, or for sunflower.

Plants or plant cultivars (obtained by plant biotechnology methods suchas genetic engineering) which may also be treated according to theinvention are insect-resistant transgenic plants, i.e. plants maderesistant to attack by certain target insects. Such plants can beobtained by genetic transformation, or by selection of plants containinga mutation imparting such insect resistance.

An “insect-resistant transgenic plant”, as used herein, includes anyplant containing at least one transgene comprising a coding sequenceencoding.

1) an insecticidal crystal protein from Bacillus thuringiensis or aninsecticidal portion thereof, such as the insecticidal crystal proteinslisted online at:http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/, or insecticidalportions thereof, e.g., proteins of the Cry protein classes Cry1Ab,Cry1Ac, Cry1F, Cry2Ab, Cry3Aa, or Cry3Bb or insecticidal portionsthereof; or

2) a crystal protein from Bacillus thuringiensis or a portion thereofwhich is insecticidal in the presence of a second other crystal proteinfrom Bacillus thuringiensis or a portion thereof, such as the binarytoxin made up of the Cry34 and Cry35 crystal proteins; or

3) a hybrid insecticidal protein comprising parts of differentinsecticidal crystal proteins from Bacillus thuringiensis, such as ahybrid of the proteins of 1) above or a hybrid of the proteins of 2)above, e.g., the Cry1A.105 protein produced by corn event MON98034 (WO2007/027777); or

4) a protein of any one of 1) to 3) above wherein some, particularly 1to 10, amino acids have been replaced by another amino acid to obtain ahigher insecticidal activity to a target insect species, or to expandthe range of target insect species affected, or because of changesintroduced into the encoding DNA during doning or transformation, suchas the Cry3Bbl protein in corn events MON863 or MON88017, or the Cry3Aprotein in corn event MIR604;

5) an insecticidal secreted protein from Bacillus thuringiensis orBacillus cereus, or an insecticidal portion thereof, such as thevegetative insecticidal (VIP) proteins listed at:

http://www.lifesci.sussex.ac.uk/home/Neil_Crickmore/Bt/vip.html, e.g.proteins from the VIP3Aa protein class; or

6) secreted protein from Bacillus thuringiensis or Bacillus cereus whichis insecticidal in the presence of a second secreted protein fromBacillus thuringiensis or B. cereus, such as the binary toxin made up ofthe VIP1A and VIP2A proteins; or

7) hybrid insecticidal protein comprising parts from different secretedproteins from Bacillus thuringiensis or Bacillus cereus, such as ahybrid of the proteins in 1) above or a hybrid of the proteins in 2)above;

or

8) protein of any one of 1) to 3) above wherein some, particularly 1 to10, amino acids have been replaced by another amino acid to obtain ahigher insecticidal activity to a target insect species, or to expandthe range of target insect species affected, or because of changesintroduced into the encoding DNA during cloning or transformation (whilestill encoding an insecticidal protein), such as the VIP3Aa protein incotton event COT102.

Of course, an insect-resistant transgenic plant, as used herein, alsoincludes any plant comprising a combination of genes encoding theproteins of any one of the above classes 1 to 8. In one embodiment, aninsect-resistant plant contains more than one transgene encoding aprotein of any one of the above classes 1 to 8, to expand the range oftarget insect species affected when using different proteins directed atdifferent target insect species, or to delay insect resistancedevelopment to the plants by using different proteins insecticidal tothe same target insect species but having a different mode of action,such as binding to different receptor binding sites in the insect.

Plants or plant cultivars (obtained by plant biotechnology methods suchas genetic engineering) which may also be treated according to theinvention are tolerant to abiotic stresses. Such plants can be obtainedby genetic transformation, or by selection of plants containing amutation imparting such stress resistance. Particularly useful stresstolerance plants include:

a. plants which contain a transgene capable of reducing the expressionor the activity of poly(ADP-ribose)polymerase (PARP) gene in the plantcells or plants

b. plants which contain a stress tolerance enhancing transgene capableof reducing the expression or the activity of the PARG encoding genes ofthe plants or plants cells.

c. plants which contain a stress tolerance enhancing transgene codingfor a plant-functional enzyme of the nicotinamide adenine dinucleotidesalvage synthesis pathway including nicotinamidase, nicotinatephosphoribosyltransferase, nicotinic acid mononucleotide adenyltransferase, nicotinamide adenine dinucleotide synthetase or nicotineamide phosphorybosyltransferase.

Plants or plant cultivars (obtained by plant biotechnology methods suchas genetic engineering) which may also be treated according to theinvention show altered quantity, quality or storage-stability of theharvested product or altered properties of specific ingredients of theharvested product such as:

1) transgenic plants which synthesize a modified starch, which in itsphysical-chemical characteristics, in particular the amylose content orthe amylose/amylopectin ratio, the degree of branching, the averagechain length, the side chain distribution, the viscosity behaviour, thegelling strength, the starch grain size or the starch grain morphology,is changed in comparison with the synthesised starch in wild type plantcells or plants, so that this is better suited for special applications.

2) transgenic plants which synthesize non starch carbohydrate polymersor which synthesize non starch carbohydrate polymers with alteredproperties in comparison to wild type plants without geneticmodification. Examples are plants producing polyfructose, especially ofthe inulin and levan-type, plants producing alpha 1,4 glucans, plantsproducing alpha-1,6 branched alpha-1,4-glucans, plants producingalteman, 3) transgenic plants which produce hyaluronan.

Plants or plant cultivars (that can be obtained by plant biotechnologymethods such as genetic engineering) which may also be treated accordingto the invention are plants, such as cotton plants, with altered fibercharacteristics. Such plants can be obtained by genetic transformationor by selection of plants contain a mutation imparting such alteredfiber characteristics and include:

a) Plants, such as cotton plants, containing an altered form ofcellulose synthase genes,

b) Plants, such as cotton plants, containing an altered form of rsw2 orrsw3 homologous nucleic acids,

c) Plants, such as cotton plants, with increased expression of sucrosephosphate synthase,

d) Plants, such as cotton plants, with increased expression of sucrosesynthase,

e) Plants, such as cotton plants, wherein the timing of theplasmodesmatal gating at the basis of the fiber cell is altered, e.g.through downregulation of fiberselective β 1,3-glucanase,

f) Plants, such as cotton plants, having fibers with altered reactivity,e.g. through the expression of N-acteylglucosaminetransferase geneincluding nodC and chitinsynthase genes.

Plants or plant cultivars (that can be obtained by plant biotechnologymethods such as genetic engineering) which may also be treated accordingto the invention are plants, such as oilseed rape or related Brassicaplants, with altered oil profile characteristics. Such plants can beobtained by genetic transformation or by selection of plants contain amutation imparting such altered oil characteristics and include:

a) Plants, such as oilseed rape plants, producing oil having a higholeic acid content,

b) Plants such as oilseed rape plants, producing oil having a lowlinolenic acid content,

c) Plant such as oilseed rape plants, producing oil having a low levelof saturated fatty acids.

Particularly useful transgenic plants which may be treated according tothe invention are plants which comprise one or more genes which encodeone or more toxins, such as the following which are sold under the tradenames YIELD GARD® (for example maize, cotton, soya beans), KnockOut®(for example maize), BiteGard® (for example maize), Bt-Xtra® (forexample maize), StarLink® (for example maize), Bollgard® (cotton),Nucotn® (cotton), Nucotn 33B®(cotton), NatureGard® (for example maize),Protecta® and NewLeaf® (potato). Examples of herbicide-tolerant plantswhich may be mentioned are maize varieties, cotton varieties and soyabean varieties which are sold under the trade names Roundup Ready®(tolerance to glyphosate, for example maize, cotton, soya bean), LibertyLink® (tolerance to phosphinotricin, for example oilseed rape), IMI®(tolerance to imidazolinones) and STS® (tolerance to sulphonylureas, forexample maize). Herbicide-resistant plants (plants bred in aconventional manner for herbicide tolerance) which may be mentionedinclude the varieties sold under the name Clearfield® (for examplemaize).

Particularly useful transgenic plants which may be treated according tothe invention are plants containing transformation events, or acombination of transformation events, and that are listed for example inthe databases for various national or regional regulatory agenciesincluding Event 1143-14A (cotton, insect control, not deposited,described in WO2006/128569); Event 1143-51B (cotton, insect control, notdeposited, described in WO2006/128570); Event 1445 (cotton, herbicidetolerance, not deposited, described in US2002120964 or WO2002/034946);Event 17053 (rice, herbicide tolerance, deposited as PTA-9843, describedin WO2010/117737); Event 17314 (rice, herbicide tolerance, deposited asPTA-9844, described in WO2010/117735); Event 281-24-236 (cotton, insectcontrol—herbicide tolerance, deposited as PTA-6233, described inWO2005/103266 or US2005216969); Event 3006-210-23 (cotton, insectcontrol—herbicide tolerance, deposited as PTA-6233, described inUS2007143876 or WO2005/103266); Event 3272 (corn, quality trait,deposited as PTA-9972, described in WO2006098952 or US2006230473); Event40416 (corn, insect control—herbicide tolerance, deposited as ATCCPTA-11508, described in WO2011/075593); Event 43A47 (corn, insectcontrol—herbicide tolerance, deposited as ATCC PTA11509, described inWO2011/075595); Event 5307 (corn, insect control, deposited as ATCCPTA-9561, described in WO2010/077816); Event ASR-368 (bent grass,herbicide tolerance, deposited as ATCC PTA4816, described inUS2006162007 or WO2004053062); Event B16 (corn, herbicide tolerance, notdeposited, described in US2003126634); Event BPS-CV127-9 (soybean,herbicide tolerance, deposited as NCIMB No. 41603, described inWO2010/080829); Event CE43-67B (cotton, insect control, deposited as DSMACC2724, described in US2009217423 or WO2006/128573); Event CE44-69D(cotton, insect control, not deposited, described in US20100024077);Event CE44-69D (cotton, insect control, not deposited, described inWO2006/128571); Event CE46-02A (cotton, insect control, not deposited,described in WO2006/128572); Event COT102 (cotton, insect control, notdeposited, described in US2006130175 or WO2004039986); Event COT202(cotton, insect control, not deposited, described in US2007067868 orWO2005054479); Event COT203 (cotton, insect control, not deposited,described in WO2005/054480); Event DAS40278 (corn, herbicide tolerance,deposited as ATCC PTA-10244, described in WO2011/022469); EventDAS-59122-7 (corn, insect control—herbicide tolerance, deposited as ATCCPTA 11384, described in US2006070139); Event DAS-59132 (corn, insectcontrol—herbicide tolerance, not deposited, described in WO2009/100188);Event DAS68416 (soybean, herbicide tolerance, deposited as ATCCPTA-10442, described in WO2011/066384 or WO2011/066360); EventDP-098140-6 (corn, herbicide tolerance, deposited as ATCC PTA-8296,described in US2009137395 or WO2008/112019); Event DP-305423-1 (soybean,quality trait, not deposited, described in US2008312082 orWO2008/054747); Event DP-32138-1 (corn, hybridization system, depositedas ATCC PTA-9158, described in US20090210970 or WO2009/103049); EventDP-356043-5 (soybean, herbicide tolerance, deposited as ATCC PTA-8287,described in US20100184079 or WO2008/002872); Event EE-1 (brinjal,insect control, not deposited, described in WO2007/091277); Event FI117(corn, herbicide tolerance, deposited as ATCC 209031, described inUS2006059581 or WO1998/044140); Event GA21 (corn, herbicide tolerance,deposited as ATCC 209033, described in US2005086719 or WO1998/044140);Event GG25 (corn, herbicide tolerance, deposited as ATCC 209032,described in US2005188434 or WO 1998/044140); Event GHB119 (cotton,insect control—herbicide tolerance, deposited as ATCC PTA-8398,described in WO2008/151780); Event GHB614 (cotton, herbicide tolerance,deposited as ATCC PTA-6878, described in US2010050282 or WO2007/017186);Event GJ11 (corn, herbicide tolerance, deposited as ATCC 209030,described in US2005188434 or WO1998/044140); Event GM RZ13 (sugar beet,virus resistance, deposited as NCIMB-41601, described in WO2010/076212);Event H7-1 (sugar beet, herbicide tolerance, deposited as NCIMB 41158 orNCIMB 41159, described in US2004172669 or WO2004/074492); Event JOPLIN1(wheat, disease tolerance, not deposited, described in US2008064032);Event LL27 (soybean, herbicide tolerance, deposited as NCIMB41658,described in WO2006/108674 or US2008320616); Event LL55 (soybean,herbicide tolerance, deposited as NCIMB 41660, described inWO2006/108675 or US2008196127); Event LLcotton25 (cotton, herbicidetolerance, deposited as ATCC PTA-3343, described in WO2003013224 orUS2003097687); Event LLRICE06 (rice, herbicide tolerance, deposited asATCC23352, described in U.S. Pat. No. 6,468,747 or WO2000/026345); EventLLRICE601 (rice, herbicide tolerance, deposited as ATCC PTA-2600,described in US20082289060 or WO2000/026356); Event LY038 (corn, qualitytrait, deposited as ATCC PTA-5623, described in US2007028322 orWO2005061720); Event MIR162 (corn, insect control, deposited asPTA-8166, described in US2009300784 or WO2007/142840); Event MIR604(corn, insect control, not deposited, described in US2008167456 orWO2005103301); Event MON15985 (cotton, insect control, deposited as ATCCPTA-2516, described in US2004-250317 or WO2002/100163); Event MON810(corn, insect control, not deposited, described in US2002102582); EventMON863 (corn, insect control, deposited as ATCC PTA-2605, described inWO2004/011601 or US2006095986); Event MON87427 (corn, pollinationcontrol, deposited as ATCC PTA-7899, described in WO2011/062904); EventMON87460 (corn, stress tolerance, deposited as ATCC PTA-8910, describedin WO2009/111263 or US20110138504); Event MON87701 (soybean, insectcontrol, deposited as ATCC PTA-8194, described in US2009130071 orWO2009/064652); Event MON87705 (soybean, quality trait—herbicidetolerance, deposited as ATCC PTA-9241, described in US20100080887 orWO2010/037016); Event MON87708 (soybean, herbicide tolerance, depositedas ATCC PTA9670, described in WO2011/034704); Event MON87754 (soybean,quality trait, deposited as ATCC PTA-9385, described in WO2010/024976);Event MON87769 (soybean, quality trait, deposited as ATCC PTA-8911,described in US20110067141 or WO2009/102873); Event MON88017 (corn,insect control—herbicide tolerance, deposited as ATCC PTA-5582,described in US2008028482 or WO2005/059103); Event MON88913 (cotton,herbicide tolerance, deposited as ATCC PTA-4854, described inWO2004/072235 or US2006059590); Event MON89034 (corn, insect control,deposited as ATCC PTA-7455, described in WO2007/140256 or US2008260932);Event MON89788 (soybean, herbicide tolerance, deposited as ATCCPTA-6708, described in US2006282915 or WO2006/130436); Event MS11(oilseed rape, pollination control—herbicide tolerance, deposited asATCC PTA-850 or PTA-2485, described in WO2001/031042); Event MS8(oilseed rape, pollination control—herbicide tolerance, deposited asATCC PTA-730, described in WO2001/041558 or US2003188347); Event NK603(corn, herbicide tolerance, deposited as ATCC PTA-2478, described inUS2007-292854); Event PE-7 (rice, insect control, not deposited,described in WO2008/114282); Event RF3 (oilseed rape, pollinationcontrol—herbicide tolerance, deposited as ATCC PTA-730, described inWO2001/041558 or US2003188347); Event RT73 (oilseed rape, herbicidetolerance, not deposited, described in WO2002/036831 or US2008070260);Event T227-1 (sugar beet, herbicide tolerance, not deposited, describedin W02002/44407 or US2009265817); Event T25 (corn, herbicide tolerance,not deposited, described in US2001029014 or WO2001/051654); EventT304-40 (cotton, insect control—herbicide tolerance, deposited as ATCCPTA-8171, described in US2010077501 or WO2008/122406); Event T342-142(cotton, insect control, not deposited, described in WO2006/128568);Event TC1507 (corn, insect control—herbicide tolerance, not deposited,described in US2005039226 or WO2004/099447); Event VIP1034 (corn, insectcontrol—herbicide tolerance, deposited as ATCC PTA-3925., described inWO2003/052073), Event 32316 (corn, insect control-herbicide tolerance,deposited as PTA-11507, described in WO2011/084632), Event 4114 (corn,insect control-herbicide tolerance, deposited as PTA-11506, described inWO2011/084621).

Particularly useful transgenic plants which may be treated according tothe invention are plants containing transformation events, orcombination of transformation events, that are listed for example in thedatabases from various national or regional regulatory agencies (see forexample

http://gmoinfo.jrc.it/gmp_browse.aspx andhttp://www.agbios.com/dbase.php).

Particularly useful transgenic plants which may be treated according tothe invention are plants containing transformation events, orcombination of transformation events, are listed in table A

TABLE A Event Company Description Crop Patent Ref A-1 ASR368 ScottsGlyphosate tolerance derived by inserting a modified 5- Agrostis USSeeds enolpyruvylshikimate-3-phosphate synthase (EPSPS) stolonifera2006162007 encoding gene from Agrobacterium tumefaciens, parent lineCreeping Bentgrass B99061 A-2 GM RZ13 Beet Necrotic Yellow Vein Virus(BNYVV) resistance Beta vulgaris WO (sugar beet) 10/076212 A-3 H7-1Monsanto Glyphosate herbicide tolerant sugar beet produced by Betavulgaris WO Company inserting a gene encoding the enzyme5-enolypyruvylshikimate- (sugar beet) 04/074492 3-phosphate synthase(EPSPS) from the CP4 strain of Agrobacterium tumefaciens A-4 T120-7Bayer Introduction of the PPT-acetyltransferase (PAT) encoding Betavulgaris CropScience gene from Streptomyces viridochromogenes, anaerobic soil (sugar beet) (Aventis bacteria. PPT normally acts toinhibit glutamine synthetase, CropScience causing a fatal accumulationof ammonia. Acetylated PPT is (AgrEvo)) inactive. A-5 GTSB77 NovartisGlyphosate herbicide tolerant sugar beet produced by Beta vulgarisSeeds; inserting a gene encoding the enzyme 5-enolypyruvylshikimate-(sugar beet) Monsanto 3-phosphate synthase (EPSPS) from the CP4 strainof Company Agrobacterium tumefaciens. A-6 T227-1 Glyphosate toleranceBeta vulgaris US (sugar beet) 2004117870 A-7 23-18-17, Monsanto Highlaurate (12:0) and myristate (14:0) canola produced by Brassica napus23-198 Company inserting a thioesterase encoding gene from theCalifornia (Argentine Canola) (formerly bay laurel (Umbellulariacalifornica). Calgene) A-8 45A37, Pioneer High oleic acid and lowlinolenic acid canola produced Brassica napus 46A40 Hi-Bred through acombination of chemical mutagenesis to select for (Argentine Canola)International a fatty acid desaturase mutant with elevated oleic acid,and Inc. traditional back-crossing to introduce the low linolenic acidtrait. A-9 46A12, Pioneer Combination of chemical mutagenesis, toachieve the high Brassica napus 46A16 Hi-Bred oleic acid trait, andtraditional breeding with registered (Argentine Canola) Internationalcanola varieties. Inc. A-10 GT200 Monsanto Glyphosate herbicide tolerantcanola produced by inserting Brassica napus Company genes encoding theenzymes 5-enolypyruvylshikimate-3- (Argentine Canola) phosphate synthase(EPSPS) from the CP4 strain of Agrobacterium tumefaciens and glyphosateoxidase from Ochrobactrum anthropi. A-11 GT73, Monsanto Glyphosateherbicide tolerant canola produced by inserting Brassica napus RT73Company genes encoding the enzymes 5-enolypyruvylshikimate-3- (ArgentineCanola) phosphate synthase (EPSPS) from the CP4 strain of Agrobacteriumtumefaciens and glyphosate oxidase from Ochrobactrum anthropi. A-12HCN10 Aventis Introduction of the PPT-acetyltransferase (PAT) encodingBrassica napus CropScience gene from Streptomyces viridochromogenes, anaerobic soil (Argentine Canola) bacteria. PPT normally acts to inhibitglutamine synthetase, causing a fatal accumulation of ammonia.Acetylated PPT is inactive. A-13 HCN92 Bayer Introduction of thePPT-acetyltransferase (PAT) encoding Brassica napus CropScience genefrom Streptomyces viridochromogenes, an aerobic soil (Argentine Canola)(Aventis bacteria. PPT normally acts to inhibit glutamine synthetase,CropScience causing a fatal accumulation of ammonia. Acetylated PPT is(AgrEvo)) inactive. A-14 MS1, Aventis Male-sterility, fertilityrestoration, pollination control Brassica napus RF1 =>PGS1 CropSciencesystem displaying glufosinate herbicide tolerance. MS lines (ArgentineCanola) (formerly contained the barnase gene from Bacillusamyloliquefaciens, RF Plant Genetic lines contained the barstar genefrom the same bacteria, and Systems) both lines contained thephosphinothricin N-acetyltransferase (PAT) encoding gene fromStreptomyces hygroscopicus. A-15 MS1, Aventis Male-sterility, fertilityrestoration, pollination control Brassica napus RF2 =>PGS2 CropSciencesystem displaying glufosinate herbicide tolerance. MS lines (ArgentineCanola) (formerly contained the barnase gene from Bacillusamyloliquefaciens, RF Plant Genetic lines contained the barstar genefrom the same bacteria, and Systems) both lines contained thephosphinothricin N-acetyltransferase (PAT) encoding gene fromStreptomyces hygroscopicus. A-16 MS8 × RF3 Bayer Male-sterility,fertility restoration, pollination control Brassica napus CropSciencesystem displaying glufosinate herbicide tolerance. MS lines (ArgentineCanola) (Aventis contained the barnase gene from Bacillusamyloliquefaciens, RF CropScience lines contained the barstar gene fromthe same bacteria, and (AgrEvo)) both lines contained thephosphinothricin N-acetyltransferase (PAT) encoding gene fromStreptomyces hygroscopicus. A-17 MS-B2 Male sterility Brassica napus WO(Argentine Canola) 01/31042 A-18 MS-BN1/ Male sterility/restorationBrassica napus WO RF-BN1 (Argentine Canola) 01/41558 A-19 NS738, PioneerSelection of somaclonal variants with altered acetolactate Brassicanapus NS1471, Hi-Bred synthase (ALS) enzymes, following chemicalmutagenesis. (Argentine Canola) NS1473 International Two lines (P1, P2)were initially selected with modifications Inc. at different unlinkedloci. NS738 contains the P2 mutation only. A-20 OXY-235 AventisTolerance to the herbicides bromoxynil and ioxynil by Brassica napusCropScience incorporation of the nitrilase gene from Klebsiella(Argentine Canola) (formerly pneumoniae. Rhône Poulenc Inc.) A-21 PHY14,Aventis Male sterility was via insertion of the barnase ribonucleaseBrassica napus PHY35 CropScience gene from Bacillus amyloliquefaciens;fertility restoration by (Argentine Canola) (formerly insertion of thebarstar RNase inhibitor; PPT resistance was Plant Genetic viaPPT-acetyltransferase (PAT) from Streptomyces Systems) hygroscopicus.A-22 PHY36 Aventis Male sterility was via insertion of the barnaseribonuclease Brassica napus CropScience gene from Bacillusamyloliquefaciens; fertility restoration by (Argentine Canola) (formerlyinsertion of the barstar RNase inhibitor; PPT resistance was PlantGenetic via PPT-acetyltransferase (PAT) from Streptomyces Systems)hygroscopicus. A-23 RT73 Glyphosate resistance Brassica napus WO(Argentine Canola) 02/6831 A-24 T45 Bayer Introduction of thePPT-acetyltransferase (PAT) encoding Brassica napus (HCN28) CropSciencegene from Streptomyces viridochromogenes, an aerobic soil (ArgentineCanola) (Aventis bacteria. PPT normally acts to inhibit glutaminesynthetase, CropScience causing a fatal accumulation of ammonia.Acetylated PPT is (AgrEvo)) inactive. A-25 HCR-1 Bayer Introduction ofthe glufosinate ammonium herbicide tolerance Brassica rapa CropSciencetrait from transgenic B. napus line T45. This trait is (Polish Canola)(Aventis mediated by the phosphinothricin acetyltransferase (PAT)CropScience encoding gene from S. viridochromogenes. (AgrEvo)) A-26ZSR500/502 Monsanto Introduction of a modified5-enol-pyruvylshikimate-3- Brassica rapa Company phosphate synthase(EPSPS) and a gene from Achromobacter (Polish Canola) sp that degradesglyphosate by conversion to aminomethylphosphonic acid (AMPA) andglyoxylate by inter- specific crossing with GT73. A-27 EE-1 Insectresistance (Cry1Ac) Brinjal WO 07/091277 A-28 55-1/63-1 Cornell Papayaringspot virus (PRSV) resistant papaya produced by Carica papayaUniversity inserting the coat protein (CP) encoding sequences from this(Papaya) plant potyvirus. A-29 X17-2 University Papaya ringspot virus(PRSV) resistant papaya produced by Carica papaya of Florida insertingthe coat protein (CP) encoding sequences from (Papaya) PRSV isolate H1Kwith a thymidine inserted after the initiation codon to yield aframeshift. Also contains nptII as a selectable marker. A-30 RM3-3, BejoMale sterility was via insertion of the barnase ribonuclease Cichoriumintybus RM3-4, Zaden BV gene from Bacillus amyloliquefaciens; PPTresistance was (Chicory) RM3-6 via the bar gene from S. hygroscopicus,which encodes the PAT enzyme. A-32 A, B Agritope Reduced accumulation ofS-adenosylmethionine (SAM), and Cucumis melo Inc. consequently reducedethylene synthesis, by introduction of (Melon) the gene encodingS-adenosylmethionine hydrolase. A-33 CZW-3 Asgrow Cucumber mosiac virus(CMV), zucchini yellows mosaic Cucurbita pepo (USA); (ZYMV) andwatermelon mosaic virus (WMV) 2 resistant (Squash) Seminis squash(Curcurbita pepo) produced by inserting the coat Vegetable protein (CP)encoding sequences from each of these plant Inc. viruses into the hostgenome. (Canada) A-34 ZW20 Upjohn Zucchini yellows mosaic (ZYMV) andwatermelon mosaic Cucurbita pepo (USA); virus (WMV) 2 resistant squash(Curcurbita pepo) produced (Squash) Seminis by inserting the coatprotein (CP) encoding sequences from Vegetable each of these plantpotyviruses into the host genome. Inc. (Canada) A-35 66 FlorigeneDelayed senescence and sulfonylurea herbicide tolerant Dianthus Pty Ltd.carnations produced by inserting a truncated copy of the caryophylluscarnation aminocyclopropane cyclase (ACC) synthase encoding (Carnation)gene in order to suppress expression of the endogenous un- modifiedgene, which is required for normal ethylene biosynthesis. Tolerance tosulfonyl urea herbicides was via the introduction of a chlorsulfurontolerant version of the acetolactate synthase (ALS) encoding gene fromtobacco. A-36 4, 11, Florigene Modified colour and sulfonylureaherbicide tolerant Dianthus 15, 16 Pty Ltd. carnations produced byinserting two anthocyanin caryophyllus biosynthetic genes whoseexpression results in a violet/ (Carnation) mauve colouration. Toleranceto sulfonyl urea herbicides was via the introduction of a chlorsulfurontolerant version of the acetolactate synthase (ALS) encoding gene fromtobacco. A-37 959A, 988A, Florigene Introduction of two anthocyaninbiosynthetic genes to result Dianthus 1226A, Pty Ltd. in a violet/mauvecolouration; Introduction of a variant form caryophyllus 1351A, ofacetolactate synthase (ALS). (Carnation) 1363A, 1400A A-38 3560.4.3.5Glyphosate/ALS inhibitor-tolerance Glycine max WO L. (Soybean)08/002872, US 2010184079 A-39 A2704-12, Bayer Glufosinate ammoniumherbicide tolerant soybean produced Glycine max WO A2704-21 CropScienceby inserting a modified phosphinothricin acetyltransferase L. (Soybean)06/108674 (Aventis (PAT) encoding gene from the soil bacteriumStreptomyces CropScience viridochromogenes (AgrEvo)) A-40 A5547-127Bayer Glufosinate ammonium herbicide tolerant soybean produced Glycinemax CropScience by inserting a modified phosphinothricinacetyltransferase L. (Soybean) (Aventis (PAT) encoding gene from thesoil bacterium Streptomyces CropScience viridochromogenes. (AgrEvo))A-41 A5547-35 Bayer Glufosinate tolerance Glycine max WO CropScience L.(Soybean) 06/108675 (Aventis CropScience (AgrEvo)) A-42 DP-305423-1Pioneer High oleic acid/ALS inhibitor tolerance; Glycine max WO Hi-BredL. (Soybean) 08/054747 International Inc. A-43 DP356043 Pioneer Soybeanevent with two herbicide tolerance genes: glyphosate Glycine max Hi-BredN-acetlytransferase, which detoxifies glyphosate, and a L. (Soybean)International modified acetolactate synthase (A Inc. A-44 G94-1, DuPontHigh oleic acid soybean produced by inserting a second copy Glycine maxG94-19, Canada of the fatty acid desaturase (GmFad2-1) encoding genefrom L. (Soybean) G168 Agricultural soybean, which resulted in“silencing” of the endogenous Products host gene. A-45 GTS 40-3-2Monsanto Glyphosate tolerant soybean variety produced by inserting aGlycine max Company modified 5-enolpyruvylshikimate-3-phosphate synthaseL. (Soybean) (EPSPS) encoding gene from the soil bacterium Agrobacteriumtumefaciens. A-46 GU262 Bayer Glufosinate ammonium herbicide tolerantsoybean produced Glycine max CropScience by inserting a modifiedphosphinothricin acetyltransferase L. (Soybean) (Aventis (PAT) encodinggene from the soil bacterium Streptomyces CropScience viridochromogenes.(AgrEvo)) A-47 MON87701 Monsanto insect resistance (CryIac) Glycine maxWO Company L. (Soybean) 09/064652 A-48 MON87705 Monsanto altered fattyacid levels (mid-oleic and low saturate) Glycine max WO Company L.(Soybean) 10/037016 A-49 MON87754 Monsanto increased oil content;Glycine max WO Company L. (Soybean) 10/024976 A-50 MON87769 Monsantostearidonic acid (SDA) comprising oil; Glycine max WO Company L.(Soybean) 09/102873 A-51 MON89788 Monsanto Glyphosate-tolerant soybeanproduced by inserting a Glycine max WO Company modified5-enolpyruvylshikimate-3-phosphate synthase L. (Soybean) 06/130436(EPSPS) encoding aroA (epsps) gene from Agrobacterium tumefaciens CP4;A-52 MON19788 Monsanto Glyphosate-tolerant soybean produced by insertinga Glycine max WO Company modified 5-enolpyruvylshikimate-3-phosphatesynthase L. (Soybean) 06/130437 (EPSPS) encoding aroA (epsps) gene fromAgrobacterium tumefaciens CP4; A-53 OT96-15 Agriculture Low linolenicacid soybean produced through traditional Glycine max & Agri-cross-breeding to incorporate the novel trait from a L. (Soybean) Foodnaturally occurring fan1 gene mutant that was selected Canada for lowlinolenic acid. A-54 W62, W98 Bayer Glufosinate ammonium herbicidetolerant soybean produced Glycine max CropScience by inserting amodified phosphinothricin acetyltransferase L. (Soybean) (Aventis (PAT)encoding gene from the soil bacterium Streptomyces CropSciencehygroscopicus. (AgrEvo)) A-55 15985 Monsanto Insect resistant cottonderived by transformation of the Gossypium Company DP50B parent variety,which contained event 531 (expressing hirsutum Cry1Ac protein), withpurified plasmid DNA containing L. (Cotton) the cry2Ab gene from B.thuringiensis subsp. kurstaki. A-56 1143-14A Insect resistance (Cry1Ab)Gossypium WO hirsutum 06/128569 L. (Cotton) A-57 1143-51B Insectresistance (Cry1Ab) Gossypium WO hirsutum 06/128570 L. (Cotton) A-5819-51A DuPont Introduction of a variant form of acetolactate synthaseGossypium Canada (ALS). hirsutum Agricultural L. (Cotton) Products A-59281-24-236 DOW Insect-resistant cotton produced by inserting the cry1Fgene Gossypium AgroSciences from Bacillus thuringiensis var. aizawai.The PAT encoding hirsutum LLC gene from Streptomyces viridochromogeneswas introduced L. (Cotton) as a selectable marker. A-60 3006- DOWInsect-resistant cotton produced by inserting the cry1Ac gene Gossypium210-23 AgroSciences from Bacillus thuringiensis subsp. kurstaki. The PATencoding hirsutum LLC gene from Streptomyces viridochromogenes wasintroduced L. (Cotton) as a selectable marker. A-61 31807/ Calgene Inc.Insect-resistant and bromoxynil herbicide tolerant cotton Gossypium31808 produced by inserting the cry1Ac gene from Bacillus hirsutumthuringiensis and a nitrilase encoding gene from Klebsiella L. (Cotton)pneumoniae. A-62 BXN Calgene Inc. Bromoxynil herbicide tolerant cottonproduced by inserting a Gossypium nitrilase encoding gene fromKlebsiella pneumoniae. hirsutum L. (Cotton) A-63 CE43-67B Insectresistance (Cry1Ab) Gossypium WO hirsutum 06/128573, L. (Cotton) US2011020828 A-64 CE44-69D Insect resistance (Cry1Ab) Gossypium WOhirsutum 06/128571 L. (Cotton) A-65 CE46-02A Insect resistance (Cry1Ab)Gossypium WO hirsutum 06/128572 L. (Cotton) A-66 Cot102 SyngentaInsect-resistant cotton produced by inserting the vip3A(a) Gossypium USSeeds, Inc. gene from Bacillus thuringiensis AB88. The APH4 encodinghirsutum 2006130175, gene from E. coli was introduced as a selectablemarker. L. (Cotton) WO 04/039986, US 2010298553 A-67 COT202 SyngentaInsect resistance (VIP3A) Gossypium US Seeds, Inc. hirsutum 2009181399L. (Cotton) A-68 Cot202 Syngenta Insect resistance (VIP3) Gossypium USSeeds, Inc. hirsutum 2007067868 L. (Cotton) A-69 Cot67B SyngentaInsect-resistant cotton produced by inserting a full-length GossypiumSeeds, Inc. cry1Ab gene from Bacillus thuringiensis. The APH4 encodinghirsutum gene from E. coli was introduced as a selectable marker. L.(Cotton) A-70 DAS- DOW WideStrike ™, a stacked insect-resistant cottonderived from Gossypium 21Ø23- AgroSciences conventional cross-breedingof parental lines 3006-210-23 hirsutum 5 × DAS- LLC (OECD identifier:DAS-21Ø23-5) and 281-24-236 (OECD L. (Cotton) 24236-5 identifier:DAS-24236-5). A-71 DAS- DOW Stacked insect-resistant andglyphosate-tolerant cotton Gossypium 21Ø23- AgroSciences derived fromconventional cross-breeding of WideStrike cotton hirsutum 5 × DAS- LLCand (OECD identifier: DAS-21Ø23-5 × DAS-24236-5) with L. (Cotton)24236-5 × Pioneer MON88913, known as RoundupReady Flex (OECD identifier:MON88913 Hi-Bred MON-88913-8). International Inc. A-72 DAS- DOWWideStrike ™/Roundup Ready ® cotton, a stacked insect- Gossypium 21Ø23-AgroSciences resistant and glyphosate-tolerant cotton derived fromhirsutum 5 × DAS- LLC conventional cross-breeding of WideStrike cotton(OECD L. (Cotton) 24236-5 × identifier: DAS-21Ø23-5 × DAS-24236-5) withMON1445 MON- (OECD identifier: MON-Ø1445-2). Ø1445-2 A-73 EE-GH3Glyphosate tolerance Gossypium WO hirsutum 07/017186 L. (Cotton) A-74EE-GH5 Insect resistance (Cry1Ab) Gossypium WO hirsutum 08/122406 L.(Cotton) A-75 EE-GH6 Insect resistance (cry2Ae) Gossypium WO hirsutum08/151780, L. (Cotton) US 2010218281 A-76 event 281- Insect resistance(Cry1F) Gossypium WO 24-236 hirsutum 05/103266 L. (Cotton) A-77 Event-1JK Agri Insect-resistant cotton produced by inserting the cry1Ac geneGossypium Genetics Ltd from Bacillus thuringiensis subsp. kurstaki HD-73(B.t.k.). hirsutum (India) L. (Cotton) A-78 event3006- Insect resistance(Cry1Ac) Gossypium WO 210-23 hirsutum 05/103266 L. (Cotton) A-79 GBH614Bayer Glyphosate herbicide tolerant cotton produced by insertingGossypium CropScience 2mepsps gene into variety Coker312 byAgrobacterium under hirsutum (Aventis the control of Ph4a748At andTPotpC L. (Cotton) CropScience (AgrEvo)) A-80 LLCotton25 BayerGlufosinate ammonium herbicide tolerant cotton produced GossypiumCropScience by inserting a modified phosphinothricin acetyltransferasehirsutum (Aventis (PAT) encoding gene from the soil bacteriumStreptomyces L. (Cotton) CropScience hygroscopicus; WO 2003013224, WO2007/017186 (AgrEvo)) A-81 LLCotton25 × Bayer Stacked herbicide tolerantand insect resistant cotton Gossypium MON15985 CropScience combiningtolerance to glufosinate ammonium herbicide from hirsutum (AventisLLCotton25 (OECD identifier: ACS-GHØØ1-3) with resistance L. (Cotton)CropScience to insects from MON15985 (OECD identifier: (AgrEvo))MON-15985-7) A-82 MON 15985 Insect resistance (Cry1A/Cry2Ab) GossypiumUS hirsutum 2004250317 L. (Cotton) A-83 MON1445/ Monsanto Glyphosateherbicide tolerant cotton produced by inserting a Gossypium 1698 Companynaturally glyphosate tolerant form of the enzyme 5- hirsutum enolpyruvylshikimate-3-phosphate synthase (EPSPS) from L. (Cotton) A. tumefaciensstrain CP4. A-84 MON15985 × Monsanto Stacked insect resistant andglyphosate tolerant cotton Gossypium MON88913 Company produced byconventional cross-breeding of the parental lines hirsutum MON88913(OECD identifier: MON-88913-8) and 15985 L. (Cotton) (OECD identifier:MON-15985-7). Glyphosate tolerance is derived from MON88913 whichcontains two genes encoding the enzyme5-enolypyruvylshikimate-3-phosphate synthase (EPSPS) from the CP4 strainof Agrobacterium tumefaciens. Insect resistance is derived MON15985which was produced by transformation of the DP50B parent variety, whichcontained event 531 (expressing Cry1Ac protein), with purified plasmidDNA containing the cry2Ab gene from B. thuringiensis subsp. kurstaki.A-85 MON- Monsanto Stacked insect resistant and herbicide tolerantcotton derived Gossypium 15985-7 × Company from conventionalcross-breeding of the parental lines 15985 hirsutum MON- (OECDidentifier: MON-15985-7) and MON1445 (OECD L. (Cotton) Ø1445-2identifier: MON-Ø1445-2). A-86 MON531/ Monsanto Insect-resistant cottonproduced by inserting the cry1Ac gene Gossypium 757/1076 Company fromBacillus thuringiensis subsp. kurstaki HD-73 (B.t.k.). hirsutum L.(Cotton) A-87 LLcotton25 Glufosinate resistance Gossypium WO hirsutum03/013224 L. (Cotton) A-88 MON88913 Monsanto Glyphosate herbicidetolerant cotton produced by inserting Gossypium WO Company two genesencoding the enzyme 5-enolypyruvylshikimate-3- hirsutum 04/072235phosphate synthase (EPSPS) from the CP4 strain of L. (Cotton)Agrobacterium tumefaciens. A-89 MON- Monsanto Stacked insect resistantand herbicide tolerant cotton derived Gossypium ØØ531-6 × Company fromconventional cross-breeding of the parental lines hirsutum MON- MON531(OECD identifier: MON-ØØ531-6) and L. (Cotton) Ø1445-2 MON1445 (OECDidentifier: MON-Ø1445-2). A-90 PV-GHGT07 Glyphosate tolerance GossypiumUS (1445) hirsutum 2004148666 L. (Cotton) A-91 T304-40 Insect-resistance(Cry1Ab) Gossypium WO hirsutum 08/122406, L. (Cotton) US 2010077501 A-92T342-142 Insect resistance (Cry1Ab) Gossypium WO hirsutum 06/128568 L.(Cotton) A-93 X81359 BASF Inc. Tolerance to imidazolinone herbicides byselection of a Helianthus naturally occurring mutant. annuus (Sunflower)A-94 RH44 BASF Inc. Selection for a mutagenized version of the enzymeLens culinaris acetohydroxyacid synthase (AHAS), also known asacetolactate (Lentil) synthase (ALS) or acetolactate pyruvate- lyase.A-95 FP967 University of A variant form of acetolactate synthase (ALS)was obtained Linum Saskatchewan, from a chlorsulfuron tolerant line ofA. thaliana and used to usitatissimum Crop transform flax. L. (Flax,Linseed) Dev. Centre A-96 5345 Monsanto Resistance to lepidopteran peststhrough the introduction of Lycopersicon Company the cry1Ac gene fromBacillus thuringiensis subsp. Kurstaki. esculentum (Tomato) A-97 8338Monsanto Introduction of a gene sequence encoding the enzyme 1-Lycopersicon Company amino-cyclopropane-1-carboxylic acid deaminase(ACCd) esculentum that metabolizes the precursor of the fruit ripeninghormone (Tomato) ethylene. A-98 1345-4 DNA Plant Delayed ripeningtomatoes produced by inserting an Lycopersicon Technology additionalcopy of a truncated gene encoding 1- esculentum Corporationaminocyclopropane-1-carboxyllic acid (ACC) synthase, (Tomato) whichresulted in downregulation of the endogenous ACC synthase and reducedethylene accumulation. A-99 35 1 N Agritope Introduction of a genesequence encoding the enzyme S- Lycopersicon Inc. adenosylmethioninehydrolase that metabolizes the precursor esculentum of the fruitripening hormone ethylene (Tomato) A-100 B, Da, F Zeneca Delayedsoftening tomatoes produced by inserting a truncated Lycopersicon Seedsversion of the polygalacturonase (PG) encoding gene in esculentum thesense or anti-sense orientation in order to reduce (Tomato) expressionof the endogenous PG gene, and thus reduce pectin degradation. A-101FLAVR Calgene Inc. Delayed softening tomatoes produced by inserting anLycopersicon SAVR additional copy of the polygalacturonase (PG) encodinggene in esculentum the anti-sense orientation in order to reduceexpression of the (Tomato) endogenous PG gene and thus reduce pectindegradation. A-102 J101, Monsanto Glyphosate herbicide tolerant alfalfa(lucerne) produced by Medicago sativa J163 Company and inserting a geneencoding the enzyme 5- (Alfalfa) Forageenolypyruvylshikimate-3-phosphate synthase (EPSPS) from Genetics the CP4strain of Agrobacterium tumefaciens. International A-103 C/F/93/08-Societe Tolerance to the herbicides bromoxynil and ioxynil by Nicotianatabacum 02 National incorporation of the nitrilase gene from KlebsiellaL. (Tobacco) d'Exploitation pneumoniae. des Tabacs et Allumettes A-104Vector Vector Reduced nicotine content through introduction of a secondNicotiana tabacum 21-41 Tobacco Inc. copy of the tobacco quinolinic acidphosphoribosyltransferase L. (Tobacco) (QTPase) in the antisenseorientation. The NPTII encoding gene from E. coli was introduced as aselectable marker to identify transformants. A-105 CL121, BASF Inc.Tolerance to the imidazolinone herbicide, imazethapyr, Oryza sativaCL141, induced by chemical mutagenesis of the acetolactate synthase(Rice) CFX51 (ALS) enzyme using ethyl methanesulfonate (EMS). A-106GAT-OS2 Glufosinate tolerance Oryza sativa WO (Rice) 01/83818 A-107GAT-OS3 Glufosinate tolerance Oryza sativa US (Rice) 2008289060 A-108IMINTA-1, BASF Inc. Tolerance to imidazolinone herbicides induced bychemical Oryza sativa IMINTA-4 mutagenesis of the acetolactate synthase(ALS) enzyme (Rice) using sodium azide. A-109 LLRICE06, AventisGlufosinate ammonium herbicide tolerant rice produced by Oryza sativaLLRICE62 CropScience inserting a modified phosphinothricinacetyltransferase (Rice) (PAT) encoding gene from the soil bacteriumStreptomyces hygroscopicus). A-110 LLRI- Bayer Glufosinate ammoniumherbicide tolerant rice produced by Oryza sativa CE601 CropScienceinserting a modified phosphinothricin acetyltransferase (Rice) (Aventis(PAT) encoding gene from the soil bacterium Streptomyces CropSciencehygroscopicus). (AgrEvo)) A-111 PE-7 Insect resistance (Cry1Ac) Oryzasativa WO (Rice) 08/114282 A-112 PWC16 BASF Inc. Tolerance to theimidazolinone herbicide, imazethapyr, Oryza sativa induced by chemicalmutagenesis of the acetolactate synthase (Rice) (ALS) enzyme using ethylmethanesulfonate (EMS). A-113 TT51 Insect resistance (Cry1Ab/Cry1Ac)Oryza sativa CN (Rice) 1840655 A-114 C5 United States Plum pox virus(PPV) resistant plum tree produced through Prunus domestica DepartmentAgrobacterium-mediated transformation with a coat protein (Plum) of (CP)gene from the virus. Agriculture - Agricultural Research Service A-115ATBT04-6, Monsanto Colorado potato beetle resistant potatoes produced bySolanum ATBT04-27, Company inserting the cry3A gene from Bacillusthuringiensis (subsp. tuberosum ATBT04-30, Tenebrionis). L. (Potato)ATBT04-31, ATBT04-36, SPBT02-5, SPBT02-7 A-116 BT6, BT10, MonsantoColorado potato beetle resistant potatoes produced by Solanum BT12,BT16, Company inserting the cry3A gene from Bacillus thuringiensis(subsp. tuberosum BT17, BT18, Tenebrionis). L. (Potato) BT23 A-117RBMT15-101, Monsanto Colorado potato beetle and potato virus Y (PVY)resistant Solanum SEMT15-02, Company potatoes produced by inserting thecry3A gene from Bacillus tuberosum SEMT15-15 thuringiensis (subsp.Tenebrionis) and the coat protein L. (Potato) encoding gene from PVY.A-118 RBMT21-129, Monsanto Colorado potato beetle and potato leafrollvirus (PLRV) Solanum RBMT21-350, Company resistant potatoes produced byinserting the cry3A gene from tuberosum RBMT22-082 Bacillusthuringiensis (subsp. Tenebrionis) and the replicase L. (Potato)encoding gene from PLRV. A-119 EH92-527 BASF Plant Crop composition;Amflora; Unique EU identifier: BPS-25271-9 Solanum Science tuberosum L.(Potato) A-120 AP205CL BASF Inc. Selection for a mutagenized version ofthe enzyme Triticum aestivum acetohydroxyacid synthase (AHAS), alsoknown as acetolactate (Wheat) synthase (ALS) or acetolactate pyruvate-lyase. A-121 AP602CL BASF Inc. Selection for a mutagenized version ofthe enzyme Triticum aestivum acetohydroxyacid synthase (AHAS), alsoknown as acetolactate (Wheat) synthase (ALS) or acetolactate pyruvate-lyase. A-122 BW255-2, BASF Inc. Selection for a mutagenized version ofthe enzyme Triticum aestivum BW238-3 acetohydroxyacid synthase (AHAS),also known as acetolactate (Wheat) synthase (ALS) or acetolactatepyruvate- lyase. A-123 BW7 BASF Inc. Tolerance to imidazolinoneherbicides induced by chemical Triticum aestivum mutagenesis of theacetohydroxyacid synthase (AHAS) gene (Wheat) using sodium azide. A-124Event 1 Fusarium resistance (trichothecene 3-O-acetyltransferase).Triticum aestivum CA (Wheat) 2561992 A-125 JOPLIN1 disease (fungal)resistance (trichothecene 3-O- Triticum aestivum US acetyltransferase).(Wheat) 2008064032 A-126 MON71800 Monsanto Glyphosate tolerant wheatvariety produced by inserting a Triticum aestivum Company modified5-enolpyruvylshikimate-3-phosphate synthase (Wheat) (EPSPS) encodinggene from the soil bacterium Agrobacterium tumefaciens, strain CP4.A-127 SWP965001 Cyanamid Selection for a mutagenized version of theenzyme Triticum aestivum Crop acetohydroxyacid synthase (AHAS), alsoknown as acetolactate (Wheat) Protection synthase (ALS) or acetolactatepyruvate- lyase. A-128 Teal 11A BASF Inc. Selection for a mutagenizedversion of the enzyme Triticum aestivum acetohydroxyacid synthase(AHAS), also known as acetolactate (Wheat) synthase (ALS) oracetolactate pyruvate- lyase. A-129 176 Syngenta Insect-resistant maizeproduced by inserting the cry1Ab gene Zea mays Seeds, Inc. from Bacillusthuringiensis subsp. kurstaki. The genetic L. (Maize) modificationaffords resistance to attack by the European corn borer (ECB). A-1303272 Self processing corn (alpha-amylase) Zea mays US L. (Maize)2006230473, US 2010063265 A-131 3751IR Pioneer Selection of somaclonalvariants by culture of embryos on Zea mays Hi-Bred imidazolinonecontaining media. L. (Maize) International Inc. A-132 676, 678, PioneerMale-sterile and glufosinate ammonium herbicide tolerant Zea mays 680Hi-Bred maize produced by inserting genes encoding DNA adenine L.(Maize) International methylase and phosphinothricin acetyltransferase(PAT) Inc. from Escherichia coli and Streptomyces viridochromogenes,respectively. A-133 ACS- Bayer Stacked insect resistant and herbicidetolerant corn hybrid Zea mays ZMØØ3-2 × CropScience derived fromconventional cross-breeding of the parental L. (Maize) MON- (Aventislines T25 (OECD identifier: ACS-ZMØØ3-2) and MON810 ØØ81Ø-6 CropScience(OECD identifier: MON-ØØ81Ø-6). (AgrEvo)) A-134 B16 Glufosinateresistance Zea mays US L. (Maize) 2003126634 A-135 B16 DekalbGlufosinate ammonium herbicide tolerant maize produced Zea mays (DLL25)Genetics by inserting the gene encoding phosphinothricin L. (Maize)Corporation acetyltransferase (PAT) from Streptomyces hygroscopicus.A-136 BT11 Syngenta Insect-resistant and herbicide tolerant maizeproduced by Zea mays WO (X4334CBR, Seeds, Inc. inserting the cry1Ab genefrom Bacillus thuringiensis subsp. L. (Maize) 10/148268 X4734CBR)kurstaki, and the phosphinothricin N-acetyltransferase (PAT) encodinggene from S. viridochromogenes. A-137 BT11 × Syngenta Stacked insectresistant and herbicide tolerant maize Zea mays GA21 Seeds, Inc.produced by conventional cross breeding of parental lines BT11 L.(Maize) (OECD unique identifier: SYN-BTØ11-1) and GA21 (OECD uniqueidentifier: MON-ØØØ21-9). A-138 BT11 × Syngenta Stacked insect resistantand herbicide tolerant maize Zea mays MIR162 Seeds, Inc. produced byconventional cross breeding of parental lines BT11 L. (Maize) (OECDunique identifier: SYN-BTØ11-1) and MIR162 (OECD unique identifier:SYN-IR162-4). Resistance to the European Corn Borer and tolerance to theherbicide glufosinate ammonium (Liberty) is derived from BT11, whichcontains the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki,and the phosphinothricin N-acetyltransferase (PAT) encoding gene from S.viridochromogenes. Resistance to other lepidopteran pests, including H.zea, S. frugiperda, A. ipsilon, and S. albicosta, is derived fromMIR162, which contains the vip3Aa gene from Bacillus thuringiensisstrain AB88. A-139 BT11 × Syngenta Bacillus thuringiensis Cry1Abdelta-endotoxin protein and Zea mays MIR162 × Seeds, Inc. the geneticmaterial necessary for its production (via L. (Maize) MIR604 elements ofvector pZO1502) in Event Bt11 corn (OECD Unique Identifier: SYN-BTØ11-1)× Bacillus thuringiensis Vip3Aa20 insecticidal protein and the geneticmaterial necessary for its production (via elements of vector pNOV1300)in Event MIR162 maize (OECD Unique Identifier: SYN- IR162-4) × modifiedCry3A protein and the genetic material necessary for its production (viaelements of vector pZM26) in Event MIR604 corn (OECD Unique Identifier:SYN- IR6Ø4-5). A-140 BT11 × Syngenta Stacked insect resistant andherbicide tolerant maize Zea mays MIR604 Seeds, Inc. produced byconventional cross breeding of parental lines BT11 L. (Maize) (OECDunique identifier: SYN-BTØ11-1) and MIR604 (OECD unique identifier:SYN-IR6Ø5-5). Resistance to the European Corn Borer and tolerance to theherbicide glufosinate ammonium (Liberty) is derived from BT11, whichcontains the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki,and the phosphinothricin N-acetyltransferase (PAT) encoding gene from S.viridochromogenes. Corn rootworm-resistance is derived from MIR604 whichcontains the mcry3A gene from Bacillus thuringiensis. A-141 BT11 ×Syngenta Stacked insect resistant and herbicide tolerant maize Zea maysMIR604 × Seeds, Inc. produced by conventional cross breeding of parentallines BT11 L. (Maize) GA21 (OECD unique identifier: SYN-BTØ11-1), MIR604(OECD unique identifier: SYN-IR6Ø5-5) and GA21 (OECD unique identifier:MON-ØØØ21-9). Resistance to the European Corn Borer and tolerance to theherbicide glufosinate ammonium (Liberty) is derived from BT11, whichcontains the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki,and the phosphinothricin N-acetyltransferase (PAT) encoding gene from S.viridochromogenes. Corn rootworm-resistance is derived from MIR604 whichcontains the mcry3A gene from Bacillus thuringiensis. Tolerance toglyphosate herbcicide is derived from GA21 which contains a a modifiedEPSPS gene from maize. A-142 CBH-351 Aventis Insect-resistant andglufosinate ammonium herbicide tolerant Zea mays CropScience maizedeveloped by inserting genes encoding Cry9C protein L. (Maize) fromBacillus thuringiensis subsp tolworthi and phosphinothricinacetyltransferase (PAT) from Streptomyces hygroscopicus. A-143DAS-06275-8 DOW Lepidopteran insect resistant and glufosinate ammoniumZea mays AgroSciences herbicide-tolerant maize variety produced byinserting the L. (Maize) LLC cry1F gene from Bacillus thuringiensis varaizawai and the phosphinothricin acetyltransferase (PAT) fromStreptomyces hygroscopicus. A-144 DAS-59122-7 DOW Cornrootworm-resistant maize produced by inserting the Zea mays USAgroSciences cry34Ab1 and cry35Ab1 genes from Bacillus thuringiensis L.(Maize) 2006070139, LLC and strain PS149B1. The PAT encoding gene fromStreptomyces US Pioneer viridochromogenes was introduced as a selectablemarker 2011030086 Hi-Bred International Inc. A-145 DAS- DOW Stackedinsect resistant and herbicide tolerant maize Zea mays 59122-7 ×AgroSciences produced by conventional cross breeding of parental linesDAS- L. (Maize) NK603 LLC and 59122-7 (OECD unique identifier:DAS-59122-7) with Pioneer NK603 (OECD unique identifier: MON-ØØ6Ø3-6).Corn Hi-Bred rootworm-resistance is derived from DAS-59122-7 whichInternational contains the cry34Ab1 and cry35Ab1 genes from BacillusInc. thuringiensis strain PS149B1. Tolerance to glyphosate herbcicide isderived from NK603. A-146 DAS- DOW Stacked insect resistant andherbicide tolerant maize Zea mays 59122-7 × AgroSciences produced byconventional cross breeding of parental lines DAS- L. (Maize) TC1507 ×LLC and 59122-7 (OECD unique identifier: DAS-59122-7) and NK603 PioneerTC1507 (OECD unique identifier: DAS-Ø15Ø7-1) with Hi-Bred NK603 (OECDunique identifier: MON-ØØ6Ø3-6). Corn International rootworm-resistanceis derived from DAS-59122-7 which Inc. contains the cry34Ab1 andcry35Ab1 genes from Bacillus thuringiensis strain PS149B1. Lepidopteranresistance and toleraance to glufosinate ammonium herbicide is derivedfrom TC1507. Tolerance to glyphosate herbcicide is derived from NK603.A-147 DAS- DOW Stacked insect resistant and herbicide tolerant cornhybrid Zea mays Ø15Ø7-1 × AgroSciences derived from conventionalcross-breeding of the parental L. (Maize) MON- LLC lines 1507 (OECDidentifier: DAS-Ø15Ø7-1) and NK603 ØØ6Ø3-6 (OECD identifier:MON-ØØ6Ø3-6). A-148 DBT418 Dekalb Insect-resistant and glufosinateammonium herbicide tolerant Zea mays Genetics maize developed byinserting genes encoding Cry1AC L. (Maize) Corporation protein fromBacillus thuringiensis subsp kurstaki and phosphinothricinacetyltransferase (PAT) from Streptomyces hygroscopicus A-149 DK404SRBASF Inc. Somaclonal variants with a modified acetyl-CoA- Zea mayscarboxylase (ACCase) were selected by culture of embryos L. (Maize) onsethoxydim enriched medium. A-150 DP-098140-6 Glyphosate tolerance/ALSinhibitor tolerance Zea mays WO L. (Maize) 08/112019, US 2010240059A-151 DP- Pioneer Corn line 98140 was genetically engineered to expressthe Zea mays Ø9814Ø-6 Hi-Bred GAT4621 (glyphosate acetyltransferase) andZM-HRA L. (Maize) (Event International (modified version of a maizeacetolactate synthase) proteins. 98140) Inc. The GAT4621 protein,encoded by the gat4621 gene, confers tolerance to glyphosate-containingherbicides by acetylating glyphosate and thereby rendering itnon-phytotoxic. The ZM-HRA protein, encoded by the zm-hra gene, conferstolerance to the ALS-inhibiting class of herbicides. A-152 EventSyngenta Maize line expressing a heat stable alpha-amylase gene Zea mays3272 Seeds, Inc. amy797E for use in the dry-grind ethanol process. TheL. (Maize) phosphomannose isomerase gene from E. coli was used as aselectable marker. A-153 Event Pioneer Maize event expressing toleranceto glyphosate herbicide, Zea mays 98140 Hi-Bred via expression of amodified bacterial glyphosate N- L. (Maize) Internationalacetlytransferase, and ALS-inhibiting herbicides, vial Inc. expressionof a modified form of the maize acetolactate synthase enzyme. A-154EXP1910IT Syngenta Tolerance to the imidazolinone herbicide,imazethapyr, Zea mays Seeds, Inc. induced by chemical mutagenesis of theacetolactate synthase L. (Maize) (formerly (ALS) enzyme using ethylmethanesulfonate (EMS). Zeneca Seeds) A-155 FI117 Glyphosate resistanceZea mays U.S. L. (Maize) Pat. No. 6,040,497 A-156 GA21 MonsantoGlyphosate resistance: Introduction, by particle bombardment, Zea maysU.S. Company of a modified 5-enolpyruvyl shikimate-3-phosphate L.(Maize) Pat. No. synthase (EPSPS), an enzyme involved in the shikimatebio- 6,040,497 chemical pathway for the production of the aromatic aminoacids; A-157 GA21 × Monsanto Stacked insect resistant and herbicidetolerant corn hybrid Zea mays MON810 Company derived from conventionalcross-breeding of the parental L. (Maize) lines GA21 (OECD identifider:MON-ØØØ21-9) and MON810 (OECD identifier: MON-ØØ81Ø-6). A-158 GAT-ZM1Glufosinate tolerance Zea mays WO L. (Maize) 01/51654 A-159 GG25Glyphosate resistance Zea mays U.S. L. (Maize) Pat. No. 6,040,497 A-160GJ11 Glyphosate resistance; U.S. Pat. No. 6,040,497 Zea mays L. (Maize)A-161 IT Pioneer Tolerance to the imidazolinone herbicide, imazethapyr,was Zea mays Hi-Bred obtained by in vitro selection of somaclonalvariants. L. (Maize) International Inc. A-162 LY038 Monsanto Alteredamino acid composition, specifically elevated levels Zea mays U.S.Company of lysine, through the introduction of the cordapA gene, L.(Maize) Pat. No. derived from Corynebacterium glutamicum, encoding the7,157,281, enzyme dihydrodipicolinate synthase (cDHDPS). US 2010212051;US 2007028322 A-163 MIR162 Insect resistance Zea mays WO L. (Maize)07/142840 A-164 MIR604 Syngenta Corn rootworm resistant maize producedby transformation Zea mays EP Seeds, Inc. with a modified cry3A gene.The phosphomannose isomerase L. (Maize) 1737290 gene from E. coli wasused as a selectable marker; (Cry3a055) A-165 MIR604 × Syngenta Stackedinsect resistant and herbicide tolerant maize Zea mays GA21 Seeds, Inc.produced by conventional cross breeding of parental lines L. (Maize)MIR604 (OECD unique identifier: SYN-IR6Ø5-5) and GA21 (OECD uniqueidentifier: MON-ØØØ21-9). Corn rootworm-resistance is derived fromMIR604 which contains the mcry3A gene from Bacillus thuringiensis.Tolerance to glyphosate herbcicide is derived from GA21. A-166 MON80100Monsanto Insect-resistant maize produced by inserting the cry1Ab geneZea mays Company from Bacillus thuringiensis subsp. kurstaki. Thegenetic L. (Maize) modification affords resistance to attack by theEuropean corn borer (ECB). A-167 MON802 Monsanto Insect-resistant andglyphosate herbicide tolerant maize Zea mays Company produced byinserting the genes encoding the Cry1Ab protein L. (Maize) from Bacillusthuringiensis and the 5-enolpyruvylshikimate- 3-phosphate synthase(EPSPS) from A. tumefaciens strain CP4. A-168 MON809 Pioneer Resistanceto European corn borer (Ostrinia nubilalis) by Zea mays Hi-Bredintroduction of a synthetic cry1Ab gene. Glyphosate resistance L.(Maize) International via introduction of the bacterial version of aplant enzyme, 5- Inc. enolpyruvyl shikimate-3-phosphate synthase(EPSPS). A-169 MON810 Monsanto Insect-resistant maize produced byinserting a truncated form Zea mays US Company of the cry1Ab gene fromBacillus thuringiensis subsp. L. (Maize) 2004180373 kurstaki HD-1. Thegenetic modification affords resistance to attack by the European cornborer (ECB); A-170 MON810 × Monsanto Stacked insect resistant andglyphosate tolerant maize Zea mays MON88017 Company derived fromconventional cross-breeding of the parental lines L. (Maize) MON810(OECD identifier: MON-ØØ81Ø-6) and MON88017 (OECD identifier:MON-88Ø17-3). European corn borer (ECB) resistance is derived from atruncated form of the cry1Ab gene from Bacillus thuringiensis subsp.kurstaki HD-1 present in MON810. Corn rootworm resistance is derivedfrom the cry3Bb1 gene from Bacillus thuringiensis subspecieskumamotoensis strain EG4691 present in MON88017. Glyphosate tolerance isderived from a 5- enolpyruvylshikimate-3-phosphate synthase (EPSPS)encoding gene from Agrobacterium tumefaciens strain CP4 present inMON88017. A-171 MON832 Monsanto Introduction, by particle bombardment,of glyphosate Zea mays Company oxidase (GOX) and a modified5-enolpyruvyl shikimate-3- L. (Maize) phosphate synthase (EPSPS), anenzyme involved in the shikimate biochemical pathway for the productionof the aromatic amino acids. A-172 MON863 Monsanto Corn root wormresistant maize produced by inserting the Zea mays Company cry3Bb1 genefrom Bacillus thuringiensis subsp. L. (Maize) kumamotoensis. A-173MON863 × Monsanto Stacked insect resistant corn hybrid derived from Zeamays MON810 Company conventional cross-breeding of the parental linesMON863 L. (Maize) (OECD identifier: MON-ØØ863-5) and MON810 (OECDidentifier: MON-ØØ81Ø-6) A-174 MON863 × Monsanto Stacked insectresistant and herbicide tolerant corn hybrid Zea mays MON810 × Companyderived from conventional cross-breeding of the stacked hybrid L.(Maize) NK603 MON-ØØ863-5 × MON-ØØ81Ø-6 and NK603 (OECD identifier:MON-ØØ6Ø3-6). A-175 MON863 × Monsanto Stacked insect resistant andherbicide tolerant corn hybrid Zea mays NK603 Company derived fromconventional cross-breeding of the parental L. (Maize) lines MON863(OECD identifier: MON-ØØ863-5) and NK603 (OECD identifier: MON-ØØ6Ø3-6).A-176 MON87460 Drought tolerance; Water deficit tolerance; Zea mays WOL. (Maize) 09/111263 A-177 MON88017 Monsanto Corn rootworm-resistantmaize produced by inserting the Zea mays WO Company cry3Bb1 gene fromBacillus thuringiensis subspecies L. (Maize) 05/059103 kumamotoensisstrain EG4691. Glyphosate tolerance derived by inserting a5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene fromAgrobacterium tumefaciens strain CP4 (Glyphosate tolerance); A-178MON89034 Monsanto Maize event expressing two different insecticidalproteins Zea mays WO Company from Bacillus thuringiensis providingresistance to number L. (Maize) 07/140256 of lepidopteran pests; nsectresistance (Lepidoptera - Cry1A.105-Cry2Ab); A-179 MON89034 × MonsantoStacked insect resistant and glyphosate tolerant maize Zea mays MON88017Company derived from conventional cross-breeding of the parental linesL. (Maize) MON89034 (OECD identifier: MON-89Ø34-3) and MON88017 (OECDidentifier: MON-88Ø17-3). Resistance to Lepiopteran insects is derivedfrom two crygenes present in MON89043. Corn rootworm resistance isderived from a single cry genes and glyphosate tolerance is derived fromthe 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding genefrom Agrobacterium tumefaciens present in MON88017. A-180 MON89034 ×Monsanto Stacked insect resistant and herbicide tolerant maize Zea maysNK603 Company produced by conventional cross breeding of parental linesL. (Maize) MON89034 (OECD identifier: MON-89Ø34-3) with NK603 (OECDunique identifier: MON-ØØ6Ø3-6). Resistance to Lepiopteran insects isderived from two crygenes present in MON89043. Tolerance to glyphosateherbcicide is derived from NK603. A-181 MON89034 × Monsanto Stackedinsect resistant and herbicide tolerant maize Zea mays TC1507 × Companyproduced by conventional cross breeding of parental lines: L. (Maize)MON88017 × MON89034, TC1507, MON88017, and DAS-59122. DAS-59122-7Resistance to the above-ground and below-ground insect pests andtolerance to glyphosate and glufosinate-ammonium containing herbicides.A-182 MON- Monsanto Stacked insect resistant and herbicide tolerant cornhybrid Zea mays ØØ6Ø3-6 × Company derived from conventionalcross-breeding of the parental L. (Maize) MON- lines NK603 (OECDidentifier: MON-ØØ6Ø3-6) and ØØ81Ø-6 MON810 (OECD identifier:MON-ØØ81Ø-6). A-183 MON- Monsanto Stacked insect resistant and enhancedlysine content maize Zea mays ØØ81Ø-6 × Company derived fromconventional cross-breeding of the parental L. (Maize) LY038 linesMON810 (OECD identifier: MON-ØØ81Ø-6) and LY038 (OECD identifier:REN-ØØØ38-3). A-184 MON- Monsanto Stacked insect resistant and herbicidetolerant corn hybrid Zea mays ØØ863-5 × Company derived fromconventional cross-breeding of the parental L. (Maize) MON- lines MON863(OECD identifier: MON-ØØ863-5) and ØØ6Ø3-6 NK603 (OECD identifier:MON-ØØ6Ø3-6). A-185 MON- Monsanto Stacked insect resistant corn hybridderived from Zea mays ØØ863-5 × Company conventional cross-breeding ofthe parental lines MON863 L. (Maize) MON- (OECD identifier: MON-ØØ863-5)and MON810 (OECD ØØ81Ø-6 identifier: MON-ØØ81Ø-6) A-186 MON- MonsantoStacked insect resistant and herbicide tolerant corn hybrid Zea maysØØ863-5 × Company derived from conventional cross-breeding of thestacked hybrid L. (Maize) MON- MON-ØØ863-5 × MON-ØØ81Ø-6 and NK603 (OECDØØ81Ø-6 × identifier: MON-ØØ6Ø3-6). MON- ØØ6Ø3-6 A-187 MON- MonsantoStacked insect resistant and herbicide tolerant corn hybrid Zea maysØØØ21-9 × Company derived from conventional cross-breeding of theparental L. (Maize) MON- lines GA21 (OECD identifider: MON-ØØØ21-9) andØØ81Ø-6 MON810 (OECD identifier: MON-ØØ81Ø-6). A-188 MS3 Bayer Malesterility caused by expression of the barnase ribonuclease Zea maysCropScience gene from Bacillus amyloliquefaciens; PPT resistance L.(Maize) (Aventis was via PPT-acetyltransferase (PAT). CropScience(AgrEvo)) A-189 MS6 Bayer Male sterility caused by expression of thebarnase ribonuclease Zea mays CropScience gene from Bacillusamyloliquefaciens; PPT resistance L. (Maize) (Aventis was viaPPT-acetyltransferase (PAT). CropScience (AgrEvo)) A-190 NK603 MonsantoIntroduction, by particle bombardment, of a modified 5- Zea mays Companyenolpyruvyl shikimate-3-phosphate synthase (EPSPS), an L. (Maize) enzymeinvolved in the shikimate biochemical pathway for the production of thearomatic amino acids. A-191 NK603 × Monsanto Stacked insect resistantand herbicide tolerant corn hybrid Zea mays MON810 Company derived fromconventional cross-breeding of the parental L. (Maize) lines NK603 (OECDidentifier: MON-ØØ6Ø3-6) and MON810 (OECD identifier: MON-ØØ81Ø-6).A-192 NK603 × Monsanto Stacked glufosinate ammonium and glyphosateherbicide Zea mays T25 Company tolerant maize hybrid derived fromconventional cross- L. (Maize) breeding of the parental lines NK603(OECD identifier: MON-ØØ6Ø3-6) and T25 (OECD identifier: ACS-ZM003-2).A-193 PV-ZMGT32 Glyphosate tolerance Zea mays US (NK603) L. (Maize)2007056056 A-194 E6611.32.1.38/ Pioneer 1) MS45: anther-specific 5126(Zea mays) promoter > fertility zea mays WO DP-32138-1/ Hi-Bredrestoration Ms45 (Zea mays) coding sequence > fertility L. (Maize)09/103049, 32138 International restoration Ms45 (Zea mays)3′-untranslated region 2) ZM- MX Inc. AA1: polygalacturonase 47 (Zeamays) promoter > brittle-1 2010008977 (Zea mays) chloroplast transitpeptide > alpha-amylase-1 (Zea mays) truncated coding sequence > >In2-1(Zea mays) 3′-untranslated region 3) DSRED2: 35S (Cauliflower MosaicVirus) enhancer > lipid transfer protein-2 (Hordeum vulgare) promoter >red fluorescent protein (Dicosoma sp.) variant coding sequence > proteininhibitor II (Solanum tuberosum) 3′-untranslated region A-195 PV-ZMIR13Insect resistance (Cry3Bb); Zea mays US (MON863) L. (Maize) 2006095986A-196 SYN- Syngenta Stacked insect resistant and herbicide tolerantmaize Zea mays BTØ11-1 × Seeds, Inc. produced by conventional crossbreeding of parental lines BT11 L. (Maize) MON- (OECD unique identifier:SYN-BTØ11-1) and GA21 ØØØ21-9 (OECD unique identifier: MON-ØØØ21-9).A-197 T14 Bayer Glufosinate herbicide tolerant maize produced byinserting Zea mays CropScience the phosphinothricin N-acetyltransferase(PAT) encoding L. (Maize) (Aventis gene from the aerobic actinomyceteStreptomyces CropScience viridochromogenes. (AgrEvo)) A-198 T14, T25Bayer Glufosinate herbicide tolerant maize produced by inserting Zeamays CropScience the phosphinothricin N-acetyltransferase (PAT) encodingL. (Maize) (Aventis gene from the aerobic actinomycete StreptomycesCropScience viridochromogenes. (AgrEvo)) A-199 T25 × Bayer Stackedinsect resistant and herbicide tolerant corn hybrid Zea mays MON810CropScience derived from conventional cross-breeding of the parental L.(Maize) (Aventis lines T25 (OECD identifier: ACS-ZMØØ3-2) and MON810CropScience (OECD identifier: MON-ØØ81Ø-6). (AgrEvo)) A-200 TC1507Mycogen Insect-resistant and glufosinate ammonium herbicide tolerant Zeamays U.S. (c/o Dow maize produced by inserting the cry1F gene fromBacillus L. (Maize) Pat. No. AgroSciences); thuringiensis var. aizawaiand the phosphinothricin N- 7,435,807 Pioneer acetyltransferase encodinggene from Streptomyces (c/o Dupont) viridochromogenes; Insect resistance(Cry1F); A-201 TC1507 × DOW Stacked insect resistant and herbicidetolerant maize Zea mays DAS-59122-7 AgroSciences produced byconventional cross breeding of parental lines L. (Maize) LLC and TC1507(OECD unique identifier: DAS-Ø15Ø7-1) with Pioneer DAS-59122-7 (OECDunique identifier: DAS-59122-7). Hi-Bred Resistance to lepidopteraninsects is derived from TC1507 due International the presence of thecry1F gene from Bacillus thuringiensis Inc. var. aizawai. Cornrootworm-resistance is derived from DAS-59122-7 which contains thecry34Ab1 and cry35Ab1 genes from Bacillus thuringiensis strain PS149B1.Tolerance to glufosinate ammonium herbcicide is derived from TC1507 fromthe phosphinothricin N-acetyltransferase encoding gene from Streptomycesviridochromogenes. A-202 VIP1034 Insect resistance; Zea mays WO L.(Maize) 03/052073 A-203 MS-B2 Male sterility Brassica ssp WO 01/31042A-204 MS-BN1/ Male sterility/restoration Brassica ssp WO RF-BN1 01/41558A-205 RT73 Glyphosate resistance Brassica ssp WO 02/36831 A-206 MON87708 MONSANTO Dicamba herbicide tolerance, transformation vector PV-Glycine max WO TECH- GMHT4355 1) DMO: full length transcript (PeanutChlorotic L. (Soybean) 11/034704 NOLOGY Streak Virus) promoter > tobaccoEtch Virus leader > LLC ribulose 1,5-biphosphate carboxylase smallsubunit (Pisum sativum) chloroplast transit peptide > dicamba mono-oxygenase (Stenotrophomonas maltophilia) coding sequence >ribulose-1,5-bisphosphate carboxylase small subunit E9 (Pisum sativum)3′-untranslated region. A CP4 epsps chimeric gene contained within asecond T-DNA on the transformation vector used was segregated away.A-207 EE-GM3/ BAYER 1) Ph4a748 ABBC: sequence including the promoterregion Glycine max WO FG72 BIOSCIENCE of the histone H4 gene ofArabidopsis thaliana, containing an L. (Soybean) 11/063411 NV [BE]; MSinternal duplication > 5′tev: sequence including the leader TECH-sequence of the tobacco etch virus > TPotp Y: coding sequence NOLOGIESof an optimized transit peptide derivative (position 55 LLC [US] changedinto Tyrosine), containing sequence of the RuBisCO small subunit genesof Zea mays (corn) and Helianthus annuus (sunflower) > hppdPfW336: thecoding sequence of the 4-hydroxyphenylpyruvate dioxygenase ofPseudomonas fluorescens strain A32 modified by the replacement of theamino acid Glycine 336 with a Tryptophane > 3′nos: sequence includingthe 3′ untranslated region of the nopaline synthase gene from the T-DNAof pTiT37 of Agrobacterium tumefaciens. 2) Ph4a748: sequence includingthe promoter region of the histone H4 gene of Arabidopsis thaliana >intron1 h3At: first intron of gene II of the histone H3.III variant ofArabidopsis thaliana > TPotp C: coding sequence of the optimized transitpeptide, containing sequence of the RuBisCO small subunit genes of Zeamays (corn) and Helianthus annuus (sunflower) > 2mepsps: the codingsequence of the double-mutant 5-enol-pyruvylshikimate-3-phosphatesynthase gene of Zea mays > 3′histonAt: sequence including the 3′untranslated region of the histone H4 gene of Arabidopsis thaliana A-208416/ DOW A novel aad-12 transformation event for herbicide toleranceGlycine max WO pDAB4468- AGRO- in soybean plants - referred to herein aspDAB4468-0416. L. (Soybean) 11/066384 0416 SCIENCES The aad-12 gene(originally from Delftia acidovorans) LLC encodes the aryloxyalkanoatedioxygenase (AAD-12) protein. The trait confers tolerance to2,4-dichlorophenoxyacetic acid, for example, and to pyridyloxyacetateherbicides. The aad-12 gene, itself, for herbicide tolerance in plantswas first disclosed in WO 07/053482. A-209 127 ALS/AHASinhibitor-tolerance Glycine max WO L. (Soybean) 10/080829 A-210 A5547-35Glufosinate tolerance Glycine max WO L. (Soybean) 06/108675 A-211A2704-12 Glufosinate tolerance Glycine max WO L. (Soybean) 06/108674A-212 Kefeng No. CHINA NAT Transgenic rice Kefeng 6 is a transformationevent containing Oryza sativa CN 6 RICE two insect-resistant genes,cry1Ac and SCK (modified (Rice) 101824411 RES INST CpTI gene) in China.A-213 17053 Glyphosate tolerance Oryza sativa WO (Rice) 10/117737 A-21417314 Glyphosate tolerance Oryza sativa WO (Rice) 10/117735 A-215 Event1 Fusarium resistance (trichothecene 3-O-acetyltransferase) Wheat CA2561992 A-216 JOPLIN1 disease (fungal) resistance (trichothecene 3-O-Wheat US acetyltransferase) 2008064032 A-217 DAS-40278-9 DOW RB7 MARv3 >zmUbiquitin 1 promoter > aad1 > zmPER5 Zea mays WO AgroSciences 3′UTR >RB 7 MARv4. The aad-1 gene confers tolerance to L. (Maize) 11/022469 LLC2,4-dichlorophenoxyacetic acid and aryloxyphenoxypropionate (commonlyreferred to as “fop” herbicides such as quizalofop) herbicides A-218MIR604 Syngenta 1) CRY3A: metallotionin-like gene (Zea mays) promoter >Zea mays US Participations delta-endotoxin cry3a (Bacillus thuringiensissubsp. L. (Maize) 2005216970, AG tenebrionis) coding sequence, modifiedto include a cathepsin-G US protease recognition site and maize codonoptimized > 2008167456, nopaline synthase (Agrobacterium tumefaciens)3′- US untranslated region 2) PMI: polyubiquitin (Zea mays) 2011111420promoter (incl. first intron) > mannose-6-phosphate isomerase(Escherichia coli) coding sequence > nopaline synthase (Agrobacteriumtumefaciens) 3′-untranslated region A-219 MON 87427 MONSANTO Thetransgene insert and expression cassette of MON 87427 Zea mays WO TECH-comprises the promoter and leader from the cauliflower L. (Maize)11/062904 NOLOGY mosaic virus (CaMV) 35 S containing a duplicatedenhancer LLC region (P-e35S); operably linked to a DNA leader derivedfrom the first intron from the maize heat shock protein 70 gene (I-HSP70); operably linked to a DNA molecule encoding an N-terminalchloroplast transit peptide from the shkG gene from Arabidopsis thalianaEPSPS (Ts-CTP2); operably linked to a DNA molecule derived from the aroAgene from the Agrobacterium sp. strain CP4 and encoding the CP4 EPSPSprotein; operably linked to a 3′ UTR DNA molecule derived from thenopaline synthase (T-NOS) gene from Agrobacterium tumefaciens. A-220DP-004114-3 Pioneer cry1F, cry34Ab1, cry35Ab1, and pat: resistance tocertain Zea mays US Hi-Bred lepidopteran and coleopteran pests, as wellas tolerance to L. (Maize) 2011154523 International phosphinothricin.Inc. A-221 DP-032316-8 Pioneer Cry1F, cry34Ab1, cry35Ab1, pat:resistance to certain Zea mays US Hi-Bred lepidopteran and coleopteranpests, as well as tolerance to L. (Maize) 2011154524 Internationalphosphinothricin Inc. A-222 DP-040416-8 a Pioneer Cry1F, cry34Ab1,cry35Ab1, pat: resistance to certain Zea mays US Hi-Bred lepidopteranand coleopteran pests, as well as tolerance to L. (Maize) 20110154525International phosphinothricin Inc. A-223 DP-043A47-3 Pioneer Cry1F,cry34Ab1, cry35Ab1, pat: resistance to certain Zea mays US Hi-Bredlepidopteran and coleopteran pests, as well as tolerance to L. (Maize)20110154526 International phosphinothricin Inc. A-224 5307 Insect (cornrootworm) resistance (FR8a) Zea mays WO L. (Maize) 10/077816

In material protection the active compounds or the active compoundcombinations of the invention may be used for the protection oftechnical materials against infestation and destruction by insects,nematodes or phytopathogens.

Technical materials are understood to be in the present contextnon-living materials that have been prepared for use in engineering. Forexample, technical materials that are to be protected againstmicro-biological change or destruction by the active materials of theinvention can be adhesives, glues, paper and cardboard, textiles,carpets, leather, wood, paint and plastic articles, cooling lubricantsand other materials that can be infested or destroyed bymicro-organisms. Within the context of materials to be protected arealso parts of production plants and buildings, for example coolingcircuits, cooling and heating systems, air conditioning and ventilationsystems, which can be adversely affected by the propagation of fungi ormicroorganisms. Within the context of the present invention, preferablymentioned as technical materials are adhesives, glues, paper andcardboard, leather, wood, paints, cooling lubricants and heat exchangerliquids, particularly preferred is wood. The combinations according tothe invention can prevent disadvantageous effects like decaying, dis-and decoloring, or molding. The active compound combinations andcompositions according to the invention can likewise be employed forprotecting against colonization of objects, in particular ship hulls,sieves, nets, buildings, quays and signalling installations, which arein contact with sea water or brackish water.

The method of treatment according to the invention can also be used inthe field of protecting storage goods against attack of insects,nematodes or phytopathogens. According to the present invention, theterm “storage goods” is understood to denote natural substances ofvegetable or animal origin and their processed forms, which have beentaken from the natural life cycle and for which long-term protection isdesired. Storage goods of vegetable origin, such as plants or partsthereof, for example stalks, leafs, tubers, seeds, fruits or grains, canbe protected in the freshly harvested state or in processed form, suchas pre-dried, moistened, comminuted, ground, pressed or roasted. Alsofalling under the definition of storage goods is timber, whether in theform of crude timber, such as construction timber, electricity pylonsand barriers, or in the form of finished articles, such as furniture orobjects made from wood. Storage goods of animal origin are hides,leather, furs, hairs and the like. The combinations according thepresent invention can prevent disadvantageous effects such as decay,discoloration or mold. Preferably “storage goods” is understood todenote natural substances of vegetable origin and their processed forms,more preferably fruits and their processed forms, such as pomes, stonefruits, soft fruits and citrus fruits and their processed forms.

Insects, nematodes or phytopathogens to be controlled when the compound(A), the spore-forming bacteria (B) and the biological control agents(C) are used or employed according to the invention are given hereafter:

Insects and Nematodes:

Insects are from the phylum Arthropoda, especially from the classArachnida, for example, Acarus spp., Aceria sheldoni, Aculops spp.,Aculus spp., Amblyomma spp., Amphitetranychus viennensis, Argas spp.,Boophilus spp., Brevipalpus spp., Bryobia graminum, Bryobia praetiosa,Centruroides spp., Chorioptes spp., Dermanyssus gallinae,Dermatophagoides pteronyssinus, Dermatophagoides farinas, Dermacentorspp., Eotetranychus spp., Epitrimerus pyri, Eutetranychus spp.,Eriophyes spp., Glycyphagus domesticus, Halotydeus destructor,Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectus spp.,Loxosceles spp., Metatetranychus spp., Neutrombicula autumnalis,Nuphersa spp., Oligonychus spp., Ornithodorus spp., Ornithonyssus spp.,Panonychus spp., Phyllocoptruta oleivora, Polyphagotarsonemus latus,Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp.,Scorpio maurus, Steneotarsonemus spp., Steneotarsonemus spinki,Tarsonemus spp., Tetranychus spp., Trombicula alfreddugesi, Vaejovisspp., Vasates lycopersici;

from the class Chilopoda, for example, Geophilus spp., Scutigera spp.;from the order or the class Collembola, for example, Onychiurus armatus;from the class Diplopoda, for example, Blaniulus guttulatus;from the class Insecta, e.g. from the order Blattodea, for example,Blattella asahinai, Blattella germanica, Blatta orientalis, Leucophaeamaderae, Panchlora spp., Parcoblatta spp., Periplaneta spp., Supellalongipalpa;from the order Coleoptera, for example, Acalymma vittatum,Acanthoscelides obtectus, Adoretus spp., Agelastica alni, Agriotes spp.,Alphitobius diaperinus, Amphimallon solstitialis, Anobium punctatum,Anoplophora spp., Anthonomus spp., Anthrenus spp., Apion spp., Apogoniaspp., Atomaria spp., Attagenus spp., Bruchidius obtectus, Bruchus spp.,Cassida spp., Cerotoma trifurcata, Ceutorrhynchus spp., Chaetocnemaspp., Cleonus mendicus, Conoderus spp., Cosmopolites spp., Costelytrazealandica, Ctenicera spp., Curculio spp., Cryptolestes ferrugineus,Cryptorhynchus lapathi, Cylindrocopturus spp., Dermestes spp.,Diabrotica spp., Dichocrocis spp., Dicladispa armigera, Diloboderusspp., Epilachna spp., Epitrix spp., Faustinus spp., Gibbium psylloides,Gnathocerus cornutus, Hellula undalis, Heteronychus arator, Heteronyxspp., Hylamorpha elegans, Hylotrupes bajulus, Hypera postica, Hypomecessquamosus, Hypothenemus spp., Lachnosterna consanguinea, Lasiodermaserricorne, Latheticus oryzae, Lathridius spp., Lema spp., Leptinotarsadecemlineata, Leucoptera spp., Lissorhoptrus oryzophilus, Lixus spp.,Luperodes spp., Lyctus spp., Megascelis spp., Melanotus spp., Meligethesaeneus, Melolontha spp., Migdolus spp., Monochamus spp., Naupactusxanthographus, Necrobia spp., Niptus hololeucus, Oryctes rhinoceros,Oryzaephilus surinamensis, Oryzaphagus oryzae, Otiorrhynchus spp.,Oxycetonia jucunda, Phaedon cochleariae, Phyllophaga spp., Phyllophagahelleri, Phyllotreta spp., Popillia japonica, Premnotrypes spp.,Prostephanus truncatus, Psylliodes spp., Ptinus spp., Rhizobiusventralis, Rhizopertha dominica, Sitophilus spp., Sitophilus oryzae,Sphenophorus spp., Stegobium paniceum, Sternechus spp., Symphyletesspp., Tanymecus spp., Tenebrio molitor, Tenebrioides mauretanicus,Tribolium spp., Trogoderma spp., Tychius spp., Xylotrechus spp., Zabrusspp.;from the order Diptera, for example, Aedes spp., Agromyza spp.,Anastrepha spp., Anopheles spp., Asphondylia spp., Bactrocera spp.,Bibio hortulanus, Calliphora erythrocephala, Calliphora vicina,Ceratitis capitata, Chironomus spp., Chrysomyia spp., Chrysops spp.,Chrysozona pluvialis, Cochliomyia spp., Contarinia spp., Cordylobiaanthropophaga, Cricotopus sylvestris, Culex spp., Culicoides spp.,Culiseta spp., Cuterebra spp., Dacus oleae, Dasyneura spp., Delia spp.,Dermatobia hominis, Drosophila spp., Echinocnemus spp., Fannia spp.,Gasterophilus spp., Glossina spp., Haematopota spp., Hydrellia spp.,Hydrellia griseola, Hylemya spp., Hippobosca spp., Hypoderma spp.,Liriomyza spp., Lucilia spp., Lutzomyia spp., Mansonia spp., Musca spp.,Oestrus spp., Oscinella frit, Paratanytarsus spp., Paralauterborniellasubcincta, Pegomyia spp., Phlebotomus spp., Phorbia spp., Phormia spp.,Piophila casei, Prodiplosis spp., Psila rosae, Rhagoletis spp.,Sarcophaga spp., Simulium spp., Stomoxys spp., Tabanus spp., Tetanopsspp., Tipula spp.;from the order Heteroptera, for example, Anasa tristis, Antestiopsisspp., Boisea spp., Blissus spp., Calocoris spp., Campylomma livida,Cavelerius spp., Cimex spp., Collaria spp., Creontiades dilutus, Dasynuspiperis, Dichelops furcatus, Diconocoris hewetti, Dysdercus spp.,Euschistus spp., Eurygaster spp., Heliopeltis spp., Horcias nobilellus,Leptocorisa spp., Leptocorisa varicornis, Leptoglossus phyllopus, Lygusspp., Macropes excavatus, Miridae, Monalonion atratum, Nezara spp.,Oebalus spp., Pentomidae, Piesma quadrata, Piezodorus spp., Psallusspp., Pseudacysta persea, Rhodnius spp., Sahlbergella singularis,Scaptocoris castanea, Scotinophora spp., Stephanitis nashi, Tibracaspp., Triatoma spp.;from the order Homoptera, for example, Acizzia acaciaebaileyanae,Acizzia dodonaeae, Acizzia uncatoides, Acrida turrita, Acyrthosiponspp., Acrogonia spp., Aeneolamia spp., Agonoscena spp., Aleyrodesproletella, Aleurolobus barodensis, Aleurothrixus floccosus,Allocaridara malayensis, Amrasca spp., Anuraphis cardui, Aonidiellaspp., Aphanostigma piri, Aphis spp., Arboridia apicalis, Arytainillaspp., Aspidiella spp., Aspidiotus spp., Atanus spp., Aulacorthum solani,Bemisia tabaci, Blastopsylla occidentalis, Boreioglycaspis melaleucae,Brachycaudus helichrysi, Brachycolus spp., Brevicoryne brassicae,Cacopsylla spp., Calligypona marginata, Carneocephala fulgida,Ceratovacuna lanigera, Cercopidae, Ceroplastes spp., Chaetosiphonfragaefolii, Chionaspis tegalensis, Chlorita onukii, Chondracris rosea,Chromaphis juglandicola, Chrysomphalus ficus, Cicadulina mbila,Coccomytilus halli, Coccus spp., Cryptomyzus ribis, Cryptoneossa spp.,Ctenarytaina spp., Dalbulus spp., Dialeurodes citri, Diaphorina citri,Diaspis spp., Drosicha spp., Dysaphis spp., Dysmicoccus spp., Empoascaspp., Eriosoma spp., Erythroneura spp., Eucalyptolyma spp., Euphylluraspp., Euscelis bilobatus, Ferrisia spp., Geococcus coffeae, Glycaspisspp., Heteropsylla cubana, Heteropsylla spinulosa, Homalodiscacoagulata, Hyalopterus arundinis, Icerya spp., Idiocerus spp.,Idioscopus spp., Laodelphax striatellus, Lecanium spp., Lepidosaphesspp., Lipaphis erysimi, Macrosiphum spp., Macrosteles facifrons,Mahanarva spp., Melanaphis sacchari, Metcalfiella spp., Metopolophiumdirhodum, Monellia costalis, Monelliopsis pecanis, Myzus spp., Nasonoviaribisnigri, Nephotettix spp., Nettigoniclla spectra, Nilaparvata lugens,Oncometopia spp., Orthezia praelonga, Oxya chinensis, Pachypsylla spp.,Parabemisia myricae, Paratrioza spp., Parlatoria spp., Pemphigus spp.,Peregrinus maidis, Phenacoccus spp., Phloeomyzus passerinii, Phorodonhumuli, Phylloxera spp., Pinnaspis aspidistras, Planococcus spp.,Prosopidopsylla flava, Protopulvinaria pyriformis, Pseudaulacaspispentagona, Pseudococcus spp., Psyllopsis spp., Psylla spp., Pteromalusspp., Pyrilla spp., Quadraspidiotus spp., Quesada gigas, Rastrococcusspp., Rhopalosiphum spp., Saissetia spp., Scaphoideus titanus,Schizaphis graminum, Selenaspidus articulatus, Sogata spp., Sogatellafurcifera, Sogatodes spp., Stictocephala festina, Siphoninus phillyreae,Tenalaphara malayensis, Tetragonocephela spp., Tinocallis caryaefoliae,Tomaspis spp., Toxoptera spp., Trialeurodes vaporariorum, Trioza spp.,Typhlocyba spp., Unaspis spp., Viteus vitifolii, Zygina spp.;from the order Hymenoptera, for example, Acromyrmex spp., Athalia spp.,Atta spp., Diprion spp., Hoplocampa spp., Lasius spp., Monomoriumpharaonis, Sirex spp., Solenopsis invicta, Tapinoma spp., Urocerus spp.,Vespa spp., Xeris spp.;from the order Isopoda, for example, Armadillidium vulgare, Oniscusasellus, Porcellio scaber;from the order Isoptera, for example, Coptotermes spp., Cornitermescumulans, Cryptotermes spp., Incisitermes spp., Microtermes obesi,Odontotermes spp., Reticulitermes spp.;from the order Lepidoptera, for example, Achroia grisella, Acronictamajor, Adoxophyes spp., Aedia leucomelas, Agrotis spp., Alabama spp.,Amyelois transitella, Anarsia spp., Anticarsia spp., Argyroploce spp.,Barathra brassicae, Borbo cinnara, Bucculatrix thurberiella, Bupaluspiniarius, Busseola spp., Cacoecia spp., Caloptilia theivora, Capuareticulana, Carpocapsa pomonella, Carposina niponensis, Cheimatobiabrumata, Chilo spp., Choristoneura spp., Clysia ambiguella,Cnaphalocerus spp., Cnaphalocrocis medinalis, Cnephasia spp.,Conopomorpha spp., Conotrachelus spp., Copitarsia spp., Cydia spp.,Dalaca noctuides, Diaphania spp., Diatraea saccharalis, Earias spp.,Ecdytolopha aurantium, Elasmopalpus lignosellus, Eldana saccharina,Ephestia spp., Epinotia spp., Epiphyas postvittana, Etiella spp., Euliaspp., Eupoecilia ambiguella, Euproctis spp., Euxoa spp., Feltia spp.,Galleria mellonella, Gracillaria spp., Grapholitha spp., Hedylepta spp.,Helicoverpa spp., Heliothis spp., Hofmannophila pseudospretella,Homoeosoma spp., Homona spp., Hyponomeuta padella, Kakivoriaflavofasciata, Laphygma spp., Laspeyresia molesta, Leucinodes orbonalis,Leucoptera spp., Lithocolletis spp., Lithophane antennata, Lobesia spp.,Loxagrotis albicosta, Lymantria spp., Lyonetia spp., Malacosomaneustria, Maruca testulalis, Mamstra brassicae, Melanitis leda, Mocisspp., Monopis obviella, Mythimna separata, Nemapogon cloacellus,Nymphula spp., Oiketicus spp., Oria spp., Orthaga spp., Ostrinia spp.,Oulema oryzae, Panolis flammea, Parnara spp., Pectinophora spp.,Perileucoptera spp., Phthorimaea spp., Phyllocnistis citrella,Phyllonorycter spp., Pieris spp., Platynota stultana, Plodiainterpunctella, Plusia spp., Plutella xylostella, Prays spp., Prodeniaspp., Protoparce spp., Pseudaletia spp., Pseudaletia unipuncta,Pseudoplusia includens, Pyrausta nubilalis, Rachiplusia nu, Schoenobiusspp., Scirpophaga spp., Scirpophaga innotata, Scotia segetum, Sesamiaspp., Sesamia inferens, Sparganothis spp., Spodoptera spp., Spodopterapraefica, Stathmopoda spp., Stomopteryx subsecivella, Synanthedon spp.,Tecia solanivora, Thermesia gemmatalis, Tinea cloacella, Tineapellionella, Tineola bisselliella, Tortrix spp., Trichophaga tapetzella,Trichoplusia spp., Tryporyza incertulas, Tuta absoluta, Virachola spp.;from the order Orthoptera or Saltatoria, for example, Acheta domesticus,Dichroplus spp., Gryllotalpa spp., Hieroglyphus spp., Locusta spp.,Melanoplus spp., Schistocerca gregaria;from the order Phthiraptera, for example, Damalinia spp., Haematopinusspp., Linognathus spp., Pediculus spp., Ptirus pubis, Trichodectes spp.;from the order Psocoptera for example Lepinatus spp., Liposcelis spp.;from the order Siphonaptera, for example, Ceratophyllus spp.,Ctenocephalides spp., Pulex irritans, Tunga penetrans, Xenopsyllacheopsis;from the order Thysanoptera, for example, Anaphothrips obscurus,Baliothrips biformis, Drepanothrips reuteri, Enneothrips flavens,Frankliniella spp., Heliothrips spp., Hercinothrips femoralis,Rhipiphorothrips cruentatus, Scirtothrips spp., Taeniothrips cardamomi,Thrips spp.;from the order Zygentoma (=Thysanura), for example, Ctenolepisma spp.,Lepisma saccharina, Lepismodes inquilinus, Thermobia domestica;from the class Symphyla, for example, Scutigerella spp.;pests from the phylum Mollusca, especially from the class Bivalvia, forexample, Dreissena spp., and from the class Gastropoda, for example,Anion spp., Biomphalaria spp., Bulinus spp., Deroceras spp., Galba spp.,Lymnaea spp., Oncomelania spp., Pomacea spp., Succinea spp.;animal pests being nematodes from the phylums Plathelminthes andNematoda, for example, Ancylostoma duodenale, Ancylostoma ceylanicum,Acylostoma braziliensis, Ancylostoma spp., Ascaris spp., Brugia malayi,Brugia timori, Bunostomum spp., Chabertia spp., Clonorchis spp.,Cooperia spp., Dicrocoelium spp., Dictyocaulus filaria, Diphyllobothriumlatum, Dracunculus medinensis, Echinococcus granulosus, Echinococcusmultilocularis, Enterobius vermicularis, Faciola spp., Haemonchus spp.,Heterakis spp., Hymenolepis nana, Hyostrongulus spp., Loa Loa,Nematodirus spp., Oesophagostomum spp., Opisthorchis spp., Onchocercavolvulus, Ostertagia spp., Paragonimus spp., Schistosomen spp.,Strongyloides fuelleborni, Strongyloides stercoralis, Stronyloides spp.,Taenia saginata, Taenia solium, Trichinella spiralis, Trichinellanativa, Trichinella britovi, Trichinella nelsoni, Trichinellapseudopsiralis, Trichostrongulus spp., Trichuris trichiura, Wuchereriabancrofti;phytoparasitic pests being nematodes from the phylum Nematoda, forexample, Aphelenchoides spp., Bursaphelenchus spp., Ditylenchus spp.,Globodera spp., Heterodera spp., Longidorus spp., Meloidogyne spp.,Pratylenchus spp., Radopholus spp., Trichodorus spp., Tylenchulus spp.,Xiphinema spp., Helicotylenchus spp., Tylenchorhynchus spp.,Scutellonema spp., Paratrichodorus spp., Meloinema spp., Paraphelenchusspp., Aglenchus spp., Belonolaimus spp., Nacobbus spp., Rotylenchulusspp., Rotylenchus spp., Neotylenchus spp., Paraphelenchus spp.,Dolichodorus spp., Hoplolaimus spp., Punctodera spp., Criconemella spp.,Quinisulcius spp., Hemicycliophora spp., Hirschmaniella spp., Anguinaspp., Subanguina spp., Hemicriconemoides spp., Psilenchus spp.,Pseudohalenchus spp., Criconemoides spp., Cacopaurus spp.

The compositions according to the invention are particularly useful incontrolling nematodes.

Ein Nematizid im Pflanzenschutz, wie hier beschrieben, bedeutet dieFähigkeit des Wirkstoffes, Nematoden zu kontrollieren.

“Controlling nematodes” according to the invention shall mean to killnematodes or to prevent their development or growth. The efficacy of thecompositions or combinations according to the invention is assessed bycomparing the mortality of nematodes, the development of galls, theformation of cysts, the concentration of nematodes per volume of soil,of cysts, the concentration of nematodes per root, the number ofnematode eggs per volume of soil, the motility of the nematodes betweena plant, a plant part or the soil treated with a composition orcombination according to the invention and the untreated plant, plantpart or soil (100%). Preferred is a reduction by 25-50% in comparisonwith the untreated plant, plant part or soil, very preferred a reductionby 40-79%, and particularly preferred the complete killing and thecomplete prevention of the development or growth by a reduction from 70%to 100% in comparison with the untreated plant, plant part or soil.

“Controlling nematodes” according to the invention shall mean thecontrol of the reproduction of the nematodes (e.g. development of cystsor eggs). The compositions according to the invention can used forkeeping the plants healthy and can be used curatively, preventively orsystemically for controlling nematodes.

The skilled person knows methods for determining the mortality ofnematodes, the development of galls, the formation of cysts, theconcentration of nematodes per volume of soil, of cysts, theconcentration of nematodes per root, the number of nematode eggs pervolume of soil, the motility of the nematodes between a plant, a plantpart or the soil. The treatment according to the invention reduces thedamages caused by nematodes to the plant and leads to an increase inyield.

“Nematodes” as used herein encompass all species of the order Nematodaand in particular species that are parasitic or cause health problems toplant or to fungi (for example species of the orders Aphelenchida,Meloidogyne, Tylenchida and others) or to humans and animals (forexample species of the orders Trichinellida, Tylenchida, Rhabditina, andSpirurida) as well as other parasitic helminths.

“Nematodes” as used herein, refer to plant nematodes meaning plantparasitic nematodes that cause damage to plants. Plant nematodesencompass plant parasitic nematodes and nematodes living in the soil.Plant parasitic nematodes include, but are not limited to, ectoparasitessuch as Xiphinema spp., Longidorus spp., and Trichodorus spp.;semiparasites such as Tylenchulus spp.; migratory endoparasites such asPratylenchus spp., Radopholus spp., and Scutellonerna spp.; sedentaryparasites such as Heterodera spp., Globoderal spp., and Meloidogynespp., and stem and leaf endoparasites such as Ditylenchus spp.,Aphelenchoides spp., and Hirshmaniella spp. Especially harmful rootparasitic soil nematodes are such as cystforming nematodes of the generaHeterodera or Globodera, and/or root knot nematodes of the genusMeloidogyne. Harmful species of these genera are for example Meloidogyneincognita, Heterodera glycines (soybean cyst nematode), Globoderapallida and Globodera rostochiensis (potato cyst nematode), whichspecies are effectively controlled with the compounds described herein.However, the use of the compounds described herein is in no wayrestricted to these genera or species, but also extends in the samemanner to other nematodes.

Plant nematodes include but are not limited to e.g. Aglenchus agricola,Anguina tritici, Aphelenchoides arachidis, Aphelenchoides fragaria andthe stem and leaf endoparasites Aphelenchoides spp. in general,Belonolaimus gracilis, Belonolaimus longicaudatus, Belonolaimus nortoni,Bursaphelenchus eremus, Bursaphelenchus xylophilus and Bursaphelenchusspp. in general, Cacopaurus pestis, Criconemella curvata, Criconemellaonoensis, Criconemella ornata, Criconemella rusium, Criconemellaxenoplax (=Mesocriconema xenoplax) and Criconemella spp. in general,Criconemoides ferniae, Criconemoides onoense, Criconemoides ornatum andCriconemoides spp. in general, Ditylenchus destructor, Ditylenchusdipsaci, Ditylenchus myceliophagus and the stem and leaf endoparasitesDitylenchus spp. in general, Dolichodorus heterocephalus, Globoderapallida (=Heterodera pallida), Globodera rostochiensis (potato cystnematode), Globodera solanacearum, Globodera tabacum, Globodera Virginiaand the sedentary, cyst forming parasites Globodera spp. in general,Helicotylenchus digonicus, Helicotylenchus dihystera, Helicotylenchuserythrine, Helicotylenchus multicinctus, Helicotylenchus nannus,Helicotylenchus pseudorobustus and Helicotylenchus spp. in general,Hemicriconemoides, Hemicycliophora arenaria, Hemicycliophora nudata,Hemicycliophora parvana, Heterodera avenae, Heterodera cruciferae,Heterodera glycines (soybean cyst nematode), Heterodera oryzae,Heterodera schachtii, Heterodera zeae and the sedentary, cyst formingparasites Heterodera spp. in general, Hirschmaniella gracilis,Hirschmaniella oryzae Hirschmaniella spinicaudata and the stem and leafendoparasites Hirschmaniella spp. in general, Hoplolaimus aegyptii,Hoplolaimus californicus, Hoplolaimus columbus, Hoplolaimus galeatus,Hoplolaimus indicus, Hoplolaimus magnistylus, Hoplolaimus pararobustus,Longidorus africanus, Longidorus breviannulatus, Longidorus elongatus,Longidorus laevicapitatus, Longidorus vineacola and the ectoparasitesLongidorus spp. in general, Meloidogyne acronea, Meloidogyne africana,Meloidogyne arenaria, Meloidogyne arenaria thamesi, Meloidogyneartiella, Meloidogyne chitwoodi, Meloidogyne coffeicola, Meloidogyneethiopica, Meloidogyne exigua, Meloidogyne graminicola, Meloidogynegraminis, Meloidogyne hapla, Meloidogyne incognita, Meloidogyneincognita acrita, Meloidogyne javanica, Meloidogyne kikuyensis,Meloidogyne naasi, Meloidogyne paranaensis, Meloidogyne thamesi and thesedentary parasites Meloidogyne spp. in general, Meloinema spp.,Nacobbus aberrans, Neotylenchus vigissi, Paraphelenchuspseudoparietinus, Paratrichodorus allius, Paratrichodorus lobatus,Paratrichodorus minor, Paratrichodorus nanus, Paratrichodorus porosus,Paratrichodorus teres and Paratrichodorus spp. in general, Paratylenchushamatus, Paratylenchus minutus, Paratylenchus projectus andParatylenchus spp. in general, Pratylenchus agilis, Pratylenchus alleni,Pratylenchus andinus, Pratylenchus brachyurus, Pratylenchus cerealis,Pratylenchus coffeae, Pratylenchus crenatus, Pratylenchus delattrei,Pratylenchus giibbicaudatus, Pratylenchus goodeyi, Pratylenchus hamatus,Pratylenchus hexincisus, Pratylenchus loosi, Pratylenchus neglectus,Pratylenchus penetrans, Pratylenchus pratensis, Pratylenchus scribneri,Pratylenchus teres, Pratylenchus thornei, Pratylenchus vulnus,Pratylenchus zeae and the migratory endoparasites Pratylenchus spp. ingeneral, Pseudohalenchus minutus, Psilenchus magnidens, Psilenchusturnidus, Punctodera chalcoensis, Quinisulcius acutus, Radopholuscitrophilus, Radopholus similis, the migratory endoparasites Radopholusspp. in general, Rotylenchulus borealis, Rotylenchulus parvus,Rotylenchulus reniformis and Rotylenchulus spp. in general, Rotylenchuslaurentinus, Rotylenchus macrodoratus, Rotylenchus robustus, Rotylenchusuniformis and Rotylenchus spp. in general, Scutellonema brachyurum,Scutellonema bradys, Scutellonema clathricaudatum and the migratoryendoparasites Scutellonema spp. in general, Subanguina radiciola,Tetylenchus nicotianae, Trichodorus cylindricus, Trichodorus minor,Trichodorus primitivus, Trichodorus proximus, Trichodorus similis,Trichodorus sparsus and the ectoparasites Trichodorus spp. in general,Tylenchorhynchus agri, Tylenchorhynchus brassicae, Tylenchorhynchusclavus, Tylenchorhynchus claytoni, Tylenchorhynchus digitatus,Tylenchorhynchus ebriensis, Tylenchorhynchus maximus, Tylenchorhynchusnudus, Tylenchorhynchus vulgaris and Tylenchorhynchus spp. in general,Tylenchulus semipenetrans and the semiparasites Tylenchulus spp. ingeneral, Xiphinema americanurn, Xiphinema brevicolle, Xiphinemadimorphicaudatum, Xiphinema index and the ectoparasites Xiphinema spp.in general.

Examples of nematodes to which a nematicide of the present invention isapplicable include, but are not limited to, nematodes of the genusMeloidogyne such as the southern root-knot nematode (Meloidogyneincognita), Javanese root-knot nematode (Meloidogyne javanica), northernroot-knot nematode (Meloidogyne hapla), and peanut root-knot nematode(Meloidogyne arenaria); nematodes of the genus Ditylenchus such as thepotato rot nematode (Ditylenchus destructor) and bulb and stem nematode(Ditylenchus dipsaci); nematodes of the genus Pratylenchus such as thecob root-lesion nematode (Pratylenchus penetrans), chrysanthemumroot-lesion nematode (Pratylenchus fallax), coffee root-lesion nematode(Pratylenchus coffeae), tea root-lesion nematode (Pratylenchus loosi),and walnut root-lesion nematode (Pratylenchus vulnus); nematodes of thegenus Globodera such as the golden nematode (Globodera rostochiensis)and potato cyst nematode (Globodera pallida); nematodes of the genusHeterodera such as the soybean cyst nematode (Heterodera glycines) andsugar beet cyst nematode (Heterodera schachtii); nematodes of the genusAphelenchoides such as the rice white-tip nematode (Aphelenchoidesbesseyi), chrysanthemum foliar nematode (Aphelenchoides ritzemabosi),and strawberry nematode (Aphelenchoides fragariae); nematodes of thegenus Aphelenchus such as the mycophagous nematode (Aphelenchus avenae);nematodes of the genus Radopholus such as the burrowing nematode(Radopholus similis); nematodes of the genus Tylenchulus such as thecitrus nematode (Tylenchulus semipenetrans); nematodes of the genusRotylenchulus such as the reniform nematode (Rotylenchulus reniformis);nematodes that occur in trees, such as the pine wood nematode(Bursaphelenchus xylophilus), and the like.

Plants for which a nematicide of the present invention can be used arenot particularly limited; for example, plants such as cereals (forexample, rice, barley, wheat, rye, oat, corn, kaoliang 5 and the like),beans (soybean, azuki, bean, broad bean, peas, peanuts and the like),fruit trees/fruits (apples, citruses, pears, grapes, peaches, Japaneseapricots, cherries, walnuts, almonds, bananas, strawberries and thelike), vegetables (cabbage, tomato, spinach, broccoli, lettuce, onion,Welsh onion, pepper and the like), root crops (carrot, potato, sweetpotato, radish, lotus root, turnip and the like), industrial crops(cotton, hemp, paper mulberry, mitsumata, rape, beet, hop, sugarcane,sugar beet, olive, rubber, coffee, tobacco, tea and the like), pepos(pumpkin, cucumber, watermelon, melon and the like), pasture plants(orchard grass, sorghum, thimosy, clover, alfalfa and the like), lawngrasses (mascarene grass, bent grass and the like), crops for flavoringsetc. (lavender, rosemary, thyme, parsley, pepper, ginger and the like),and flower plants (chrysanthemum, rose, orchids and the like) can bementioned.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are particularly useful in controlling nematodes incoffee belonging to at least one species selected from the group of thephytoparasitic nematodes consisting of Pratylenchus brachyurus,Pratylenchus coffeae, Meloidogyne exigua, Meloidogyne incognita,Meloidogyne coffeicola, Helicotylenchus spp. and also consisting ofMeloidogyne paranaensis, Rotylenchus spp., Xiphinema spp.,Tylenchorhynchus spp., Scutellonema spp.

Compound(s) and compositions comprising compound(s) of the presentinvention is/are particularly useful in controlling nematodes in potatobelonging to at least one species selected from the group of thephytoparasitic nematodes consisting of Pratylenchus brachyurus,Pratylenchus pratensis, Pratylenchus scribneri, Pratylenchus penetrans,Pratylenchus coffeae, Ditylenchus dipsaci and also consisting ofPratylenchus alleni, Pratylenchus andinus, Pratylenchus cerealis,Pratylenchus crenatus, Pratylenchus hexincisus, Pratylenchus loosi,Pratylenchus neglectus, Pratylenchus teres, Pratylenchus thornei,Pratylenchus vulnus, Belonolaimus longicaudatus, Trichodoruscylindricus, Trichodorus primitivus, Trichodorus proximus, Trichodorussimilis, Trichodorus sparsus, Paratrichodorus minor, Paratrichodorusallius, Paratrichodorus nanus, Paratrichodorus teres, Meloidogynearenaria, Meloidogyne hapla, Meloidogyne thamesi, Meloidogyne incognita,Meloidogyne chitwoodi, Meloidogyne javanica, Nacobbus aberrans,Globodera rostochiensis, Globodera pallida, Ditylenchus destructor,Radopholus similis, Rotylenchulus reniformis, Neotylenchus vigissi,Paraphelenchus pseudoparietinus, Aphelenchoides fragariae, Meloinemaspp.

Compound(s) and compositions comprising the compound(s) of the presentinvention is/are particularly useful in controlling nematodes in tomatobelonging to at least one species selected from the group of thephytoparasitic nematodes consisting of Meloidogyne arenaria, Meloidogynehapla, Meloidogyne javanica, Meloidogyne incognita, Pratylenchuspenetrans and also consisting of Pratylenchus brachyurus, Pratylenchuscoffeae, Pratylenchus scribneri, Pratylenchus vulnus, Paratrichodorusminor, Meloidogyne exigua, Nacobbus aberrans, Globodera solanacearum,Dolichodorus heterocephalus, Rotylenchulus reniform is.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are particularly useful in controlling nematodes incucurbits belonging to at least one species selected from the group ofthe phytoparasitic nematodes consisting of Meloidogyne arenaria,Meloidogyne hapla, Meloidogyne javanica, Meloidogyne incognita,Rotylenchulus reniformis and also consisting of Pratylenchus thornei.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are particularly useful in controlling nematodes incotton belonging to at least one species selected from the group of thephytoparasitic nematodes consisting of Belonolaimus longicaudatus,Meloidogyne incognita, Hoplolaimus columbus, Hoplolaimus galeatus,Rotylenchulus reniformis.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are particularly useful in controlling nematodes incorn belonging to at least one species selected from the group of thephytoparasitic nematodes, especially consisting of Belonolaimuslongicaudatus, Paratrichodorus minor and also consisting of Pratylenchusbrachyurus, Pratylenchus delattrei, Pratylenchus hexincisus,Pratylenchus penetrans, Pratylenchus zeae, (Belonolaimus gracilis),Belonolaimus nortoni, Longidorus breviannulatus, Meloidogyne arenaria,Meloidogyne arenaria thamesi, Meloidogyne graminis, Meloidogyneincognita, Meloidogyne incognita acrita, Meloidogyne javanica,Meloidogyne naasi, Heterodera avenae, Heterodera oryzae, Heteroderazeae, Punctodera chalcoensis, Ditylenchus dipsaci, Hoplolaimus aegyptii,Hoplolaimus magnistylus, Hoplolaimus galeatus, Hoplolaimus indicus,Helicotylenchus digonicus, Helicotylenchus dihystera, Helicotylenchuspseudorobustus, Xiphinema americanum, Dolichodorus heterocephalus,Criconemella ornata, Criconemella onoensis, Radopholus similis,Rotylenchulus borealis, Rotylenchulus parvus, Tylenchorhynchus agri,Tylenchorhynchus clavus, Tylenchorhynchus claytoni, Tylenchorhynchusmaximus, Tylenchorhynchus nudus, Tylenchorhynchus vulgaris, Quinisulciusacutus, Paratylenchus minutus, Hemicycliophora parvana, Aglenchusagricola, Anguina tritici, Aphelenchoides arachidis, Scutellonemabrachyurum, Subanguina radiciola.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are particularly useful in controlling nematodes insoybean belonging to at least one species selected from the group of thephytoparasitic nematodes, especially consisting of Pratylenchusbrachyurus, Pratylenchus pratensis, Pratylenchus penetrans, Pratylenchusscribneri, Belonolaimus longicaudatus, Heterodera glycines, Hoplolaimuscolumbus and also consisting of Pratylenchus coffeae, Pratylenchushexincisus, Pratylenchus neglectus, Pratylenchus crenatus, Pratylenchusalleni, Pratylenchus agilis, Pratylenchus zeae, Pratylenchus vulnus,(Belonolaimus gracilis), Meloidogyne arenaria, Meloidogyne incognita,Meloidogyne javanica, Meloidogyne hapla, Hoplolaimus columbus,Hoplolaimus galeatus, Rotylenchulus reniformis.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are very particularly useful in controllingnematodes in soybean belonging to at least one species selected from thegroup of the phytoparasitic nematodes, especially consisting ofPratylenchus brachyurus, Pratylenchus pratensis, Pratylenchus penetrans,Pratylenchus scribneri, Belonolaimus longicaudatus, Hoplolaimus columbusand also consisting of Pratylenchus coffeae, Pratylenchus hexincisus,Pratylenchus neglectus, Pratylenchus crenatus, Pratylenchus alleni,Pratylenchus agilis, Pratylenchus zeae, Pratylenchus vulnus,(Belonolaimus gracilis), Meloidogyne arenaria, Meloidogyne incognita,Meloidogyne javanica, Meloidogyne hapla, Hoplolaimus columbus,Hoplolaimus galeatus, Rotylenchulus reniformis.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are particularly useful in controlling nematodes intobacco belonging to at least one species selected from the group of thephytoparasitic nematodes, especially consisting of Meloidogyneincognita, Meloidogyne javanica and also consisting of Pratylenchusbrachyurus, Pratylenchus pratensis, Pratylenchus hexincisus,Pratylenchus penetrans, Pratylenchus neglectus, Pratylenchus crenatus,Pratylenchus thornei, Pratylenchus vulnus, Pratylenchus zeae, Longidoruselongatu, Paratrichodorus lobatus, Trichodorus spp., Meloidogynearenaria, Meloidogyne hapla, Globodera tabacum, Globodera solanacearum,Globodera virginiae, Ditylenchus dipsaci, Rotylenchus spp.,Helicotylenchus spp., Xiphinema americanum, Criconemella spp.,Rotylenchulus reniformis, Tylenchorhynchus claytoni, Paratylenchus spp.,Tetylenchus nicotianae.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are particularly useful in controlling nematodes incitrus belonging to at least one species selected from the group of thephytoparasitic nematodes, especially consisting of Pratylenchus coffeaeand also consisting of Pratylenchus brachyurus, Pratylenchus vulnus,Belonolaimus longicaudatus, Paratrichodorus minor, Paratrichodorusporosus, Trichodorus, Meloidogyne incognita, Meloidogyne incognitaacrita, Meloidogyne javanica, Rotylenchus macrodoratus, Xiphinemaamericanum, Xiphinema brevicolle, Xiphinema index, Criconemella spp.,Hemicriconemoides, (Radopholus similis), Radopholus citrophilus,Hemicycliophora arenaria, Hemicycliophora nudata, Tylenchulussemipenetrans.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are particularly useful in controlling nematodes inbanana belonging to at least one species selected from the group of thephytoparasitic nematodes, especially consisting of Pratylenchus coffeae,Radopholus similis and also consisting of Pratylenchus giibbicaudatus,Pratylenchus loosi, Meloidogyne spp., Helicotylenchus multicinctus,Helicotylenchus dihystera, Rotylenchulus spp.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are particularly useful in controlling nematodes inpine apple belonging to at least one species selected from the group ofthe phytoparasitic nematodes, especially consisting of Pratylenchuszeae, Pratylenchus pratensis, Pratylenchus brachyurus, Pratylenchusgoodeyi., Meloidogyne spp., Rotylenchulus reniformis and also consistingof Longidorus elongatus, Longidorus laevicapitatus, Trichodorusprimitivus, Trichodorus minor, Heterodera spp., Ditylenchusmyceliophagus, Hoplolaimus californicus, Hoplolaimus pararobustus,Hoplolaimus indicus, Helicotylenchus dihystera, Helicotylenchus nannus,Helicotylenchus multicinctus, Helicotylenchus erythrine, Xiphinemadimorphicaudatum, Radopholus similis, Tylenchorhynchus digitatus,Tylenchorhynchus ebriensis, Paratylenchus minutus, Scutellonemaclathricaudatum, Scutellonema bradys, Psilenchus tumidus, Psilenchusmagnidens, Pseudohalenchus minutus, Criconemoides ferniae, Criconemoidesonoense, Criconemoides ornatum.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are particularly useful in controlling nematodes ingrapes belonging to at least one species selected from the group of thephytoparasitic nematodes, especially consisting of Pratylenchus vulnus,Meloidogyne arenaria, Meloidogyne incognita, Meloidogyne javanica,Xiphinema americanum, Xiphinema index and also consisting ofPratylenchus pratensis, Pratylenchus scribneri, Pratylenchus neglectus,Pratylenchus brachyurus, Pratylenchus thornei, Tylenchulussemipenetrans.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are particularly useful in controlling nematodes intree crops—pome fruits, belonging to at least one species selected fromthe group of the phytoparasitic nematodes, especially consisting ofPratylenchus penetrans and also consisting of Pratylenchus vulnus,Longidorus elongatus, Meloidogyne incognita, Meloidogyne hapla.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are particularly useful in controlling nematodes intree crops—stone fruits, belonging to at least one species selected fromthe group of the phytoparasitic nematodes, especially consisting ofPratylenchus penetrans, Pratylenchus vulnus, Meloidogyne arenaria,Meloidogyne hapla, Meloidogyne javanica, Meloidogyne incognita,Criconemella xenoplax and also consisting of Pratylenchus brachyurus,Pratylenchus coffeae, Pratylenchus scribneri, Pratylenchus zeae,Belonolaimus longicaudatus, Helicotylenchus dihystera, Xiphinemaamericanum, Criconemella curvata, Tylenchorhynchus claytoni,Paratylenchus hamatus, Paratylenchus projectus, Scutellonema brachyurum,Hoplolaimus galeatus.

The compound(s) and compositions comprising the compound(s) of thepresent invention is/are particularly useful in controlling nematodes intree crops—nuts, belonging to at least one species selected from thegroup of the phytoparasitic nematodes, especially consisting ofTrichodorus spp., Criconemella rusium and also consisting ofPratylenchus vulnus, Paratrichodorus spp., Meloidogyne incognita,Helicotylenchus spp., Tylenchorhynchus spp., Cacopaurus pestis.

In a like manner, “nematodes” as used herein, refer to nematodes whichcause damage to humans or animals.

Specific nematode species harmful to humans or animals are:

Trichinellida for example: Trichuris spp., Capillaria spp.,Trichomosoides spp., Trichinella spp.

From the order of the Tylenchida for example: Micronema spp.,Strongyloides spp.

From the order of the Rhabditina for example: Strongylus spp.,Triodontophorus spp., Oesophagodontus spp., Trichonema spp.,Gyalocephalus spp., Cylindropharynx spp., Poteriostomum spp.,Cyclococercus spp., Cylicostephanus spp., Oesophagostomum spp.,Chabertia spp., Stephanurus spp., Ancylostoma spp., Uncinaria spp.,Bunostomum spp., Globocephalus spp., Syngamus spp., Cyathostoma spp.,Metastrongylus spp., Dictyocaulus spp., Muellerius spp., Protostrongylusspp., Neostrongylus spp., Cystocaulus spp., Pneumostrongylus spp.,Spicocaulus spp., Elaphostrongylus spp. Parelaphostrongylus spp.,Crenosoma spp., Paracrenosoma spp., Angiostrongylus spp.,Aelurostrongylus spp., Filaroides spp., Parafilaroides spp.,Trichostrongylus spp., Haemonchus spp., Ostertagia spp., Marshallagiaspp., Cooperia spp., Nematodirus spp., Hyostrongylus spp., Obeliscoidesspp., Amidostomum spp., Ollulanus spp.

From the order of the Spirurida for example: Oxyuris spp., Enterobiusspp., Passalurus spp., Syphacia spp., Aspiculuris spp., Heterakis spp.;Ascaris spp., Toxascaris spp., Toxocara spp., Baylisascaris spp.,Parascaris spp., Anisakis spp., Ascaridia spp.; Gnathostoma spp.,Physaloptera spp., Thelazia spp., Gongylonema spp., Habronema spp.,Parabronema spp., Draschia spp., Dracunculus spp.; Stephanofilaria spp.,Parafilaria spp., Setaria spp., Loa spp., Dirofilaria spp., Litomosoidesspp., Brugia spp., Wuchereria spp., Onchocerca spp.

Many known nematicides are equally active against other parasitichelminths and are therefore used to control human and animal parasiticworms, which do not necessarily belong to the group of nematoda.Therefore, it is envisaged by the present invention that the compoundsdescribed herein may also be used as anthelmintic drugs in a moregeneral meaning. Pathogenic endoparasitic helminths includeplatyhelmintha (e.g. monogenea, cestodes and trematodes),acanthocephala, and pentastoma. The following helminths may be mentionedby way of example and by way of preference—but without any limitation:

Monogenea: e.g.: Gyrodactylus spp., Dactylogyrus spp., Polystoma spp.

Cestodes: From the order of the Pseudophyllidea for example:Diphyllobothrium spp., Spirometra spp., Schistocephalus spp., Ligulaspp., Bothridium spp., Diplogonoporus spp.

From the order of the Cyclophyllida for example: Mesocestoides spp.,Anoplocephala spp., Paranoplocephala spp., Moniezia spp., Thysanosomaspp., Thysaniezia spp., Avitellina spp., Stilesia spp., Cittotaeniaspp., Andyra spp., Bertiella spp., Taenia spp., Echinococcus spp.,Hydatigera spp., Davainea spp., Raillietina spp., Hymenolepis spp.,Echinolepis spp., Echinocotyle spp., Diorchis spp., Dipylidium spp.,Joyeuxiella spp., Diplopylidium spp.

Trematodes: From the class of the Digenea for example: Diplostomum spp.,Posthodiplostomum spp., Schistosoma spp., Trichobilharzia spp.,Ornithobilharzia spp., Austrobilharzia spp., Gigantobilharzia spp.,Leucochloridium spp., Brachylaima spp., Echinostoma spp.,Echinoparyphium spp., Echinochasmus spp., Hypoderaeum spp., Fasciolaspp., Fasciolides spp., Fasciolopsis spp., Cyclocoelum spp.,Typhlocoelum spp., Paramphistomum spp., Calicophoron spp., Cotylophoronspp., Gigantocotyle spp., Fischoederius spp., Gastrothylacus spp.,Notocotylus spp., Catatropis spp., Plagiorchis spp., Prosthogonimusspp., Dicrocoelium spp., Eurytrema spp., Troglotrema spp., Paragonimusspp., Collyriclum spp., Nanophyetus spp., Opisthorchis spp., Clonorchisspp., Metorchis spp., Heterophyes spp., Metagonimus spp.

Acantocephala: From the order of the Oligacanthorhynchida z.B:Macracanthorhynchus spp., Prosthenorchis spp.; from the order of thePolymorphida for example: Filicollis spp.; from the order of theMoniliformida for example: Moniliformis spp.,

From the order of the Echinorhynchida for example Acanthocephalus spp.,Echinorhynchus spp., Leptorhynchoides spp.

Pentastoma: From the order of the Porocephalida for example Linguatulaspp.

In the veterinary field and in animal keeping, the administration of theactive compounds according to the invention is carried out in the knownmanner directly or enterally, parenterally, dermally or nasally in theform of suitable preparations. Administration can be carried outprophylactically or therapeutically.

Some phytopathogens of fungal diseases which can be treated by thecombination according to the invention comprising compound (A), thespore-forming bacteria (B) and the biological control agents (C) may bementioned by way of example, but not by way of limitation:

Powdery Mildew Diseases such as Blumeria diseases caused for example byBlumeria graminis; Podosphaera diseases caused for example byPodosphaera leucotricha; Sphaerotheca diseases caused for example bySphaerotheca fuliginea; Uncinula diseases caused for example by Uncinulanecator;

Rust Diseases such as Gymnosporangium diseases caused for example byGymnosporangium sabinae; Hemileia diseases caused for example byHemileia vastatrix; Phakopsora diseases caused for example by Phakopsorapachyrhizi and Phakopsora meibomiae; Puccinia diseases caused forexample by Puccinia recondita, Puccinia graminis or Pucciniastriiformis; Uromyces diseases caused for example by Uromycesappendiculatus;

Oomycete Diseases such as Albugo diseases caused for example by Albugocandida; Bremia diseases caused for example by Bremia lactucae;Peronospora diseases caused for example by Peronospora pisi andPeronospora brassicae; Phytophthora diseases caused for example byPhytophthora infestans;

Plasmopara diseases caused for example by Plasmopara viticola;Pseudoperonospora diseases caused for example by Pseudoperonosporahumuli and Pseudoperonospora cubensis; Pythium diseases caused forexample by Pythium ultimum;

Leaf spot, Leaf blotch and Leaf Blight Diseases such as Alternariadiseases caused for example by Alternaria solani; Cercospora diseasescaused for example by Cercospora beticola; Cladiosporium diseases causedfor example by Cladiosporium cucumerinum; Cochliobolus diseases causedfor example by Cochliobolus sativus (Conidiaform: Drechslera, Syn:Helminthosporium) or Cochliobolus miyabeanus; Colletotrichum diseasescaused for example by Colletotrichum lindemuthianum; Cycloconiumdiseases caused for example by Cycloconium oleaginum; Diaporthe diseasescaused for example by Diaporthe citri; Elsinoe diseases caused forexample by Elsinoe fawcettii; Gloeosporium diseases caused for exampleby Gloeosporium laeticolor; Glomerella diseases caused for example byGlomerella cingulata; Guignardia diseases caused for example byGuignardia bidwellii; Leptosphaeria diseases caused for example byLeptosphaeria maculans and Leptosphaeria nodorum; Magnaporthe diseasescaused for example by Magnaporthe grisea; Mycosphaerella diseases causedfor example by Mycosphaerella graminicola, Mycosphaerella arachidicolaand Mycosphaerella fijiensis; Phaeosphaeria diseases caused for exampleby Phaeosphaeria nodorum; Pyrenophora diseases caused for example byPyrenophora teres or Pyrenophora tritici repentis; Ramularia—diseasescaused for example by Ramularia collo-cygni or Ramularia areola;Rhynchosporium diseases caused for example by Rhynchosporium secalis;Septoria diseases caused for example by Septoria apii and Septorialycopersici; Typhula diseases caused for example by Thyphula incarnata;Venturia diseases caused for example by Venturia inaequalis;

Root-, Sheath and Stem Diseases such as Corticium diseases caused forexample by Corticium graminearum; Fusarium diseases caused for exampleby Fusarium oxysporum; Gaeumannomyces diseases caused for example byGaeumannomyces graminis; Rhizoctonia diseases caused for example byRhizoctonia solani; Sarocladium diseases caused for example bySarocladium oryzae; Sclerotium diseases caused for example by Sclerotiumoryzae; Tapesia diseases caused for example by Tapesia acuformis;Thielaviopsis diseases caused for example by Thielaviopsis basicola;

Ear and Panicle Diseases including Maize cob such as Alternaria diseasescaused for example by Alternaria spp.; Aspergillus diseases caused forexample by Aspergillus flavus; Cladosporium diseases caused for exampleby Cladiosporium cladosporioides; Claviceps diseases caused for exampleby Claviceps purpurea; Fusarium diseases caused for example by Fusariumculmorum; Gibberella diseases caused for example by Gibberella zeae;Monographella diseases caused for example by Monographella nivalis;

Smut- and Bunt Diseases such as Sphacelotheca diseases caused forexample by Sphacelotheca reiliana; Tilletia diseases caused for exampleby Tilletia caries; Urocystis diseases caused for example by Urocystisocculta; Ustilago diseases caused for example by Ustilago nuda;

Fruit Rot and Mould Diseases such as Aspergillus diseases caused forexample by Aspergillus flavus; Botrytis diseases caused for example byBotrytis cinerea; Penicillium diseases caused for example by Penicilliumexpansum and Penicillium purpurogenum; Rhizopus diseases caused byexample by Rhizopus stolonifer Sclerotinia diseases caused for exampleby Sclerotinia sclerotiorum; Verticillium diseases caused for example byVerticillium alboatrum;

Seed- and Soilborne Decay, Mould, Wilt, Rot and Damping-off diseasescaused for example by Alternaria diseases caused for example byAlternaria brassicicola; Aphanomyces diseases caused for example byAphanomyces euteiches; Ascochyta diseases caused for example byAscochyta lentis; Aspergillus diseases caused for example by Aspergillusflavus; Cladosporium diseases caused for example by Cladosporiumherbarum; Cochliobolus diseases caused for example by Cochliobolussativus; (Conidiaform: Drechslera, Bipolaris Syn: Helminthosporium);Colletotrichum diseases caused for example by Colletotrichum coccodes;Fusarium diseases caused for example by Fusarium culmorum; Gibberelladiseases caused for example by Gibberella zeae; Macrophomina diseasescaused for example by Macrophomina phaseolina; Microdochium diseasescaused for example by Microdochium nivale; Monographella diseases causedfor example by Monographella nivalis; Penicillium diseases caused forexample by Penicillium expansum; Phoma diseases caused for example byPhoma lingam; Phomopsis diseases caused for example by Phomopsis sojae;Phytophthora diseases caused for example by Phytophthora cactorum;Pyrenophora diseases caused for example by Pyrenophora graminea;Pyricularia diseases caused for example by Pyricularia oryzae; Pythiumdiseases caused for example by Pythium ultimum; Rhizoctonia diseasescaused for example by Rhizoctonia solani; Rhizopus diseases caused forexample by Rhizopus oryzae; Sclerotium diseases caused for example bySclerotium rolfsii; Septoria diseases caused for example by Septorianodorum; Typhula diseases caused for example by Typhula incarnata;Verticillium diseases caused for example by Verticillium dahlias;

Canker, Broom and Dieback Diseases such as Nectria diseases caused forexample by Nectria galligena;

Blight Diseases such as Monilinia diseases caused for example byMonilinia laxa;

Leaf Blister or Leaf Curl Diseases including deformation of blooms andfruits such as Exobasidium diseases caused for example by Exobasidiumvexans.

Taphrina diseases caused for example by Taphrina deformans;

Decline Diseases of Wooden Plants such as Esca disease caused forexample by Phaeomoniella clamydospora, Phaeoacremonium aleophilum andFomitiporia mediterranea; Ganoderma diseases caused for example byGanoderma boninense; Rigidoporus diseases caused for example byRigidoporus lignosus

Diseases of Flowers and Seeds such as Botrytis diseases caused forexample by Botrytis cinerea;

Diseases of Tubers such as Rhizoctonia diseases caused for example byRhizoctonia solani; Helminthosporium diseases caused for example byHelminthosporium solani;

Club root diseases such as Plasmodiophora diseases, cause for example byPlamodiophora brassicae.

Diseases caused by Bacterial Organisms such as Xanthomonas species forexample Xanthomonas campestris pv. oryzae; Pseudomonas species forexample Pseudomonas syringae pv. lachrymans; Erwinia species for exampleErwinia amylovora.

Preference is given to controlling the following diseases of soya beans:

Fungal diseases on leaves, stems, pods and seeds caused, for example, byalternaria leaf spot (Alternaria spec. atrans tenuissima), anthracnose(Colletotrichum gloeosporoides dematium var. truncatum), brown spot(Septoria glycines), cercospora leaf spot and blight (Cercosporakikuchii), choanephora leaf blight (Choanephora infundibulifera trispora(Syn.)), dactuliophora leaf spot (Dactuliophora glycines), downy mildew(Peronospora manshurica), drechslera blight (Drechslera glycini),frogeye leaf spot (Cercospora sojina), leptosphaerulina leaf spot(Leptosphaerulina trifolii), phyllostica leaf spot (Phyllostictasojaecola), pod and stem blight (Phomopsis sojae), powdery mildew(Microsphaera diffusa), pyrenochaeta leaf spot (Pyrenochaeta glycines),rhizoctonia aerial, foliage, and web blight (Rhizoctonia solani), rust(Phakopsora pachyrhizi Phakopsora meibomiae), scab (Sphacelomaglycines), stemphylium leaf blight (Stemphylium botryosum), target spot(Corynespora cassiicola).

Fungal diseases on roots and the stem base caused, for example, by blackroot rot (Calonectria crotalariae), charcoal rot (Macrophominaphaseolina), fusarium blight or wilt, root rot, and pod and collar rot(Fusarium oxysporum, Fusarium orthoceras, Fusarium semitectum, Fusariumequiseti), mycoleptodiscus root rot (Mycoleptodiscus terrestris),neocosmospora (Neocosmopspora vasinfecta), pod and stem blight(Diaporthe phaseolorum), stem canker (Diaporthe phaseolorum var.caulivora), phytophthora rot (Phytophthora megasperma), brown stem rot(Phialophora gregata), pythium rot (Pythium aphanidermatum, Pythiumirregulare, Pythium debaryanum, Pythium myriotylum, Pythium ultimum),rhizoctonia root rot, stem decay, and damping-off (Rhizoctonia solani),sclerotinia stem decay (Sclerotinia sclerotiorum), sclerotinia Southernblight (Sclerotinia rolfsii), thielaviopsis root rot (Thielaviopsisbasicola).

It is also possible to control resistant strains of the organismsmentioned above.

Phytopathogens capable of degrading or changing the industrial materialswhich may be mentioned are, for example, bacteria, fungi, yeasts, algaeand slime organisms. The active compound combinations and compositionsaccording to the invention preferably act against phytopathogens, inparticular moulds, wood-discolouring and wood-destroying fungi(Basidiomycetes) and against slime organisms and algae. Phytopathogensof the following genera may be mentioned as examples: Alternaria, suchas Alternaria tenuis, Aspergillus, such as Aspergillus niger,Chaetomium, such as Chaetomium globosum, Coniophora, such as Coniophorapuetana, Lentinus, such as Lentinus tigrinus, Penicillium, such asPenicillium glaucum, Polyporus, such as Polyporus versicolor,Aureobasidium, such as Aureobasidium pullulans, Sclerophoma, such asSclerophoma pityophila, Trichoderma, such as Trichoderma viride,Escherichia, such as Escherichia coli, Pseudomonas, such as Pseudomonasaeruginosa, and Staphylococcus, such as Staphylococcus aureus.

In addition, the combination comprising (A) Fluopyram, (B) aspore-forming bacterium of the genera Bacillus, and (C) a biologicalcontrol agent, in particular bacteria, fungi or yeasts, protozoa,viruses, entomopathogenic nematodes, inoculants, botanicals and productsproduced by microorganisms including proteins or secondary metabolites,particularly (C8.1) Harpin according to the invention also have verygood antimycotic activity. They have a very broad antimycotic activityspectrum in particular against dermatophytes and yeasts, moulds anddiphasic fungi (for example against Candida species such as Candidaalbicans, Candida glabrata) and Epidermophyton floccosum, Aspergillusspecies such as Aspergillus niger and Aspergillus fumigatus,Trichophyton species such as Trichophyton mentagrophytes, Microsporonspecies such as Microsporon canis and audouinii. The list of these fungiby no means limits the mycotic spectrum which can be covered, but isonly for illustration.

When applying the compounds or the active compound combination accordingto the invention the application rates can be varied within a broadrange. The dose of active compound combination/application rate usuallyapplied in the method of treatment according to the invention isgenerally and advantageously

-   -   for treatment of part of plants, e.g. leaves (foliar treatment):        from 0.01 to 10,000 g/ha, preferably from 50 to 1,000 g/ha, more        preferably from 100 to 750 g/ha; in case of drench or drip        application, the dose can even be reduced, especially while        using inert substrates like rockwool or perlite;    -   for seed treatment: from 2 to 250 g per 100 kg of seed,        preferably from 3 to 200 g per 100 kg of seed, more preferably        from 2.5 to 50 g per 100 kg of seed, even more preferably from        2.5 to 25 g per 100 kg of seed;    -   for soil treatment: from 0.01 to 10,000 g/ha, preferably from 1        to 5,000 g/ha.

The doses herein indicated are given as illustrative examples of themethod according to the invention. A person skilled in the art will knowhow to adapt the application doses, notably according to the nature ofthe plant or crop to be treated.

The active compound combination or composition according to theinvention can be used in order to protect plants within a certain timerange after the treatment against pests or phytopathogenic fungi ormicroorganisms. The time range, in which protection is effected, spansin general 1 to 28 days, preferably 1 to 14 days, more preferably 1 to10 days, even more preferably 1 to 7 days after the treatment of theplants with the combinations or up to 200 days after the treatment ofplant propagation material.

The application of the active compound combination or compositionsaccording to the invention on growing plants or plant parts can also beused to protect plants or plant parts after harvesting.

According to the invention, post-harvest and storage diseases may becaused for example by the following fungi: Colletotrichum spp., e.g.Colletotrichum musae, Colletotrichum gloeosporioides, Colletotrichumcoccodes; Fusarium spp., e.g. Fusarium semitectum, Fusarium moniliforme,Fusarium solani, Fusarium oxysporum; Verticillium spp., e.g.Verticillium theobromae; Nigrospora spp.; Botrytis spp., e.g. Botrytiscinerea; Geotrichum spp., e.g. Geotrichum candidum; Phomopsis spp.,Phomopsis natalensis; Diplodia spp., e.g. Diplodia citri; Alternariaspp., e.g. Alternaria citri, Alternaria alternata; Phytophthora spp.,e.g. Phytophthora citrophthora, Phytophthora fragariae, Phytophthoracactorum, Phytophthora parasitica; Septoria spp., e.g. Septoriadepressa; Mucor spp., e.g. Mucor piriformis; Monilinia spp., e.g.Monilinia fructigena, Monilinia laxa; Venturia spp., e.g. Venturiainaequalis, Venturia pyrina; Rhizopus spp., e.g. Rhizopus stolonifer,Rhizopus oryzae; Glomerella spp., e.g. Glomerella cingulata; Sclerotiniaspp., e.g. Sclerotinia fruiticola; Ceratocystis spp., e.g. Ceratocystisparadoxa; Penicillium spp., e.g. Penicillium funiculosum, Penicilliumexpansum, Penicillium digitatum, Penicillium italicum; Gloeosporiumspp., e.g. Gloeosporium album, Gloeosporium perennans, Gloeosporiumfructigenum, Gloeosporium singulata; Phlyctaena spp., e.g. Phlyctaenavagabunda; Cylindrocarpon spp., e.g. Cylindrocarpon mali; Stemphylliumspp., e.g. Stemphyllium vesicarium; Phacydiopycnis spp., e.g.Phacydiopycnis malirum; Thielaviopsis spp., e.g. Thielaviopsis paradoxy;Aspergillus spp., e.g. Aspergillus niger, Aspergillus carbonarius;Nectria spp., e.g. Nectria galligena; Pezicula spp.

According to the invention, post-harvest storage disorders are forexample scald, scorch, softening, senescent breakdown, lenticel spots,bitter pit, browning, water core, vascular breakdown, CO₂ injury, CO₂deficiency and O₂ deficiency.

Furthermore combinations and compositions according to the invention mayalso be used to reduce the contents of mycotoxins in plants and theharvested plant material and therefore in foods and animal feed stuffmade therefrom. Especially but not exclusively the following mycotoxinscan be specified: Deoxynivalenole (DON), Nivalenole, 15-Ac-DON,3-Ac-DON, T2-und HT2-Toxins, Fumonisines, Zearalenone Moniliformine,Fusarine, Diaceotoxyscirpenole (DAS), Beauvericine, Enniatine,Fusaroproliferine, Fusarenole, Ochratoxines, Patuline, Ergotalkaloidesund Aflatoxins, which are caused for example by the following fungaldiseases: Fusarium spec., like Fusarium acuminatum, F. avenaceum, F.crookwellense, F. culmorum, F. graminearum (Gibberella zeae), F.equiseti, F. fujikoroi, F. musarum, F. oxysporum, F. proliferatum, F.poae, F. pseudograminearum, F. sambucinum, F. scirpi, F. semitectum, F.solani, F. sporotrichoides, F. langsethiae, F. subglutinans, F.tricinctum, F. verticillioides and others but also by Aspergillus spec.,Penicillium spec., Claviceps purpurea, Stachybotrys spec. and others.

The good fungicidal or insecticidal or nematicidal activity of theactive compound combinations according to the invention is evident fromthe example below. While the individual active compounds exhibitweaknesses with regard to the fungicidal or insecticidal or nematicidalactivity, the combinations have an activity which exceeds a simpleaddition of activities.

A synergistic effect of the combinations according to the invention isalways present when the fungicidal or nematicidal or nematicidalactivity of the active compound combinations exceeds the total of theactivities of the active compounds when applied individually.

The expected activity for a given combination of two active compoundscan be calculated as follows (cf. Colby, S. R., “Calculating Synergisticand Antagonistic Responses of Herbicide Combinations”, Weeds 1967, 15,20-22):

If

-   X is the efficacy when active compound A is applied at an    application rate of m ppm (or g/ha),-   Y is the efficacy when active compound B is applied at an    application rate of n ppm (or g/ha),-   Z is the efficacy when employing active compound C at an application    rate of r ppm (or g/ha),-   E¹ is the efficacy when the active compounds A and B (or A and C, or    B and C) are applied at application rates of m and n (or m and r, or    n and r) ppm (or g/ha), respectively, and-   E2 is the efficacy when employing active compounds A and B and C at    application rates of m and n and r ppm (or g/ha),

then

$E_{1} = {X + Y - \frac{X \cdot Y}{100}}$

and for a combination of 3 active compounds:

$E_{2} = {X + Y + Z - \left( \frac{{X \cdot Y} + {X \cdot Z} + {Y \cdot Z}}{100} \right) + \frac{X \cdot Y \cdot Z}{10000}}$

The degree of efficacy, expressed in % is denoted. 0% means an efficacywhich corresponds to that of the control while an efficacy of 100% meansthat no disease is observed. If the actual fungicidal or nematicidalactivity exceeds the calculated value, then the activity of thecombination is superadditive, i.e. a synergistic effect exists. In thiscase, the efficacy which was actually observed must be greater than thevalue for the expected efficacy (E) calculated from the abovementionedformula. A further way of demonstrating a synergistic effect is themethod of Tammes (cf. “Isoboles, a graphic representation of synergismin pesticides” in Neth. J. Plant Path., 1964, 70, 73-80).

EXAMPLE 1 Meloidogyne incognita—Test (MELGIN)

Solvent: 125.0 parts by weight of acetone

To produce a suitable preparation of active compound, 1 part by weightof active compound is mixed with the stated amount of solvent, and theconcentrate is diluted with water to the desired concentration. Thepreparation of the bacteria, fungi or yeast products contains 10⁹-10¹⁰spores/g or cells/g. To produce a suitable preparation of a biologicalsuspension the cells or spores are diluted with emulsifier-containingwater to the desired concentration.

Vessels are filled with sand, a solution of the active ingredient, asuspension containing eggs and larvae of Meloidogyne incognita and saladseeds. The salad seeds germinate and the seedlings grow. Galls developin the roots.

After the specified period of time the nematicidal activity isdetermined on the basis of the percentage of gall formation. WhenMeloidogyne incognita attacks roots of plants, it deforms the normalroot cells and establishes giant cells and consequently the attackedroots form galls. 100% means that no galls were found; 0% means that thenumber of galls found on the roots of the treated plants was equal tothat in untreated control plants.

The following combinations of Bacillus firmus CNCM I-1582, Fluopyram andan additional compound showed a synergistic effect according to theinvention:

Concentration Active ingredient ppm Mortality in % after 21^(d) Bacillusfirmus CNCM I-1582 100 0 Fluopyram 0.0005 0 Bacillus thuringiensissubsp. tenebrionis 10 0 obs.* cal.** Bacillus firmus CNCM I-1582 +Fluopyram + 100 + 0.0005 + 10 90 0 B. thuringiensis tenebrionisMetarhizium anisopliae strain F52 5 0 obs.* cal.** Bacillus firmus CNCMI-1582 + Fluopyram + 100 + 0.0005 + 5 70 0 M. anisopliae strain F52*obs. = observed insecticidal efficacy, **cal. = efficacy calculatedwith Colby-formula

1. Active compound combination comprising: (A) Fluopyram, (B) aspore-forming bacterium of the genera Bacillus, selected from the groupconsisting of Bacillus firmus, Bacillus firmus strain CNCM I1582,Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillussubtilis strain GB03, Bacillus subtilis strain QST713, and (C) at leastone biological control agent selected from the group consisting of (C1)bacteria, (C2) fungi or yeasts, (C3) protozoas, (C4) viruses, (C5)entomopathogenic nematodes, (C6) inoculants, (C7) botanicals, and (C8.1)Harpin (produced by Erwinia amylovora): with the proviso that thespore-forming bacterium (B) of the genera Bacillus and the biologicalcontrol agent (C) are not identical.
 2. Active compound combinationaccording to claim 1, wherein the combination has fungicidal andnematicidal and optionally insecticidal activity.
 3. Active compoundcombination according to claim 1, wherein the spore-forming bacterium(B) of the genera Bacillus is selected from the group consisting of (B1)Bacillus firmus strain CNCM I-1582, (B2) Bacillus cereus strain CNCMI-1562, (B3) Bacillus amyloliquefaciens strain IN937a, (B4) Bacillusamyloliquefaciens strain FZB42, (B5) Bacillus subtilis strain GB03, (B6)Bacillus subtilis strain QST713, (B7) Bacillus pumilus strain GB34, (B8)Bacillus pumilus strain QST2808.
 4. Active compound combinationaccording to claim 1, wherein (C) is selected from the group consisting(C1) bacteria including spore-forming, root-colonizing bacteria, orbacteria useful as biofungicide, bioinsecticide or nematicide selectedfrom the group consisting of (C1.1) Bacillus agri, (C1.2) Bacillusaizawai, (C1.3) Bacillus albolactis, (C1.6) Bacillus coagulans, (C1.7)Bacillus endoparasiticus, (C1.8) Bacillus endorhythmos, (C1.9) Bacillusazotoformans, (C1.10) Bacillus kurstaki, (C1.11) Bacillus lacticola,(C1.12) Bacillus lactimorbus, (C1.13) Bacillus lactis, (C1.14) Bacilluslaterosporus, (C1.15) Bacillus lentimorbus, (C1.16) Bacilluslicheniformis, optionally strain SB3086 (product known as EcoGuard™Biofungicide or Green Releaf from Novozymes Biologicals, US), (C1.17)Bacillus medusa, (C1.18) Bacillus megaterium, (C1.19) Bacillus metiens,(C1.20) Bacillus natto, (C1.21) Bacillus nigrificans, (C1.22) Bacilluspopillae (also known as Paenibacillus popilliae, product known as Milkyspore disease from St. Gabriel Laboratories), (C1.24) Bacillussiamensis, (C1.25) Bacillus sphaericus, optionally Serotype H5a5b strain2362, (product known as VectoLex® from Valent BioSciences, US), (C1.26)Bacillus subtilis var. amyloliquefaciens strain FZB24 (products known asTaegro®, Rhizopro, FZB24), (C1.27) Bacillus thuringiensis, optionally(C1.27a) Bacillus thuringiensis var. israelensis (serotype H-14),optionally strain AM65-52 (Accession No. ATCC 1276, products known asVectoBac®, from Valent BioSciences, US) or strain BMP 144, (productknown as Aquabac from Becker Microbial Products IL), (C1.27b) Bacillusthuringiensis subsp. aizawai strain ABTS-1857 (products known asXenTari® from Bayer Crop Science, DE) or strain GC-91 (Accession No.NCTC 11821), or serotype H-7, (products known as Florbac WG from ValentBioSciences, US) or (C1.27c) Bacillus thuringiensis subsp. kurstakistrain HD-1, (products known as Dipel® ES from Valent BioSciences, US),or strain BMP 123 from Becker Microbial Products, IL, or strain ABTS 351(Accession No. ATCC SD-1275), or strain PB 54 (Accession No. CECT 7209),or strain SA 11 (Accession No. NRRL B-30790), or strain SA 12 (AccessionNo. NRRL B-30791), or strain EG 2348 (Accession No. NRRL B-18208) or(C1.27d) Bacillus thuringiensis subsp. tenebrionis strain NB 176(products known as Novodor® FC from BioFa, DE) or (C1.27e) Bacillusthuringiensis subsp. morrisoni or (C1.27f) Bacillus thuringiensis var.san diego (product known as M-One® from Mycogen Corporation, US) or(C1.27g) Bacillus thuringiensis subsp. thuringiensis (serotype 1)MPPL002, or (C1.27h) Bacillus thuringiensis var. aegyptii, or (C1.27k)Bacillus thuringiensis var. colmeri, or (C1.27l) Bacillus thuringiensisvar. darmstadiensis, or (C1.27m) Bacillus thuringiensis var.dendrolimus, or (C1.27n) Bacillus thuringiensis var. galleriae, or(C1.27o) Bacillus thuringiensis var. japonensis, in particular strainBuibui or (C1.27r) Bacillus thuringiensis var. 7216 (products known asAmactic, Pethian), or (C1.27s) Bacillus thuringiensis var. T36, or(C1.27t) Bacillus thuringiensis strain BD#32 (Accession No. NRRLB-21530) from Agraquest, or (C1.27u) Bacillus thuringiensis strain AQ52(Accession No. NRRL B21619) from Agraquest, or (C1.27v) Bacillusthuringiensis strain CR-371 (Accession No. ATCC 55273), (C1.28) Bacillusuniflagellatus, (C1.29) Delftia acidovorans, in particular strain RAY209(products known as) BioBoost®, (C1.30) Lysobacter antibioticus,optionally strain 13-1 (cf. Biological Control 2008, 45, 288-296),(C1.31) Pasteuria penetrans (synonym Bacillus penetrans), (C1.32)Pseudomonas chlororaphis, optionally strain MA 342 (products known asCedomon from Bioagri, S) or strain 63-28 (product known as ATEze fromEcoSoil Systems, US), (C1.33) Pseudomonas proradix (products known as)Proradix®, (C1.34) Streptomyces galbus, optionally in particular strainK61 (Accession No. DSM 7206, products known as Mycostop®, cf. CropProtection 2006, 25, 468-475) or strain NRRL 30232, (C1.35) Streptomycesgriseoviridis (products known as) Mycostop®, (C1.36) Bacillus lautus,(C1.37) Bacillus atrophaeus, (C1.39) Bacillus mycoides, optionallyisolate J (product known as BmJ from Certis USA) or strain 683 or strainAQ726 (Accession No. NRRL B21664), (C1.40) Bacillus acidoterrestris,(C1.41) Bacillus fastidiosus, (C1.42) Bacillus megaterium (productsknown as Bioarc®, from BioArc), or strain YFM3.25, (C1.43) Bacilluspsychrosaccharolyticus, (C1.44) Bacillus maroccanus, (C1.45) Bacillusmegaterium C, (C1.46) Bacillus pantothenticus (also known asVirgibacillus pantothenticus), in particular strain ATCC 14576/DSM 491,(C1.47) Bacillus lentus, (C1.48) Bacillus badius, (C1.49) Bacillussmithi, (C1.50) Acinetobacter spec, (C1.51) Acinetobacter lwoffii,(C1.52) Bacillus luciferensis, (C1.53) Chromobacterium subtsugae,optionally strain PRAA4-1T (product known as Grandevo, from Marrone BioInnovations), (C1.54) Pasteuria usgae (product known as Econem™Biological Nematicide), (C1.55) Paenibacillus polymyxa, optionallystrain AC-1 (product known as Topseed from Green Biotech Company Ltd.),(C1.57) Serratia entomophila (product known as Invade®), (C1.58)Bacillus chitinosporus, optionally strain AQ746 (Accession No. NRRLB-21618), (C1.59) Pseudomonas cepacia (ex Burkholderia cepacia, productknown as Deny from Stine Microbial Products), (C1.60) Bacillusnematocida, optionally strain B-16, (C1.61) Bacillus circulans, (C1.62)Brevibacillus laterosporus (also known as Bacillus laterosporus),optionally strain ATCC 64 or strain NRS 1111 or strain NRS 1645 orstrain NRS 1647 or strain BPM3 or strain G4 or strain NCIMB 41419,(C1.63) Corynebacterium paurometabolum, (C1.64) Lactobacillusacidophilus (products known as Fruitsan® from Inagrosa-IndustriasAgrobiologicas, S.A), (C1.65) Paenibacillus alvei, optionally strain T36or strain III3DT-1A or strain III2E or strain 46C3 or strain 2771,(C1.66) Paenibacillus macerans, (C1.67) Pasteuria nishizawae, optionallystrain Pn1, (C1.68) Pasteuria ramosa, (C1.69) Pasteuria thornei, (C1.70)Pseudomonas aeruginosa, optionally strains WS-1 or PN1, (C1.71)Pseudomonas aureofaciens, optionally strain TX-1 (product known asSpot-Less Biofungicide from Eco Soils Systems, CA), (C1.72) Pseudomonasfluorescens, optionally in particular strain A506 (products known asBlightban or BlightBan A506 from NuFarm), (C1.73) Pseudomonas putida,(C1.74) Pseudomonas resinovorans (products known as Solanacure), (C1.75)Pseudomonas syringae, optionally strain MA-4 (products known as Biosavefrom EcoScience, US), (C1.76) Serratia marcescens, optionally strain SRM(MTCC8708) or strain R35, (C1.77) Streptomyces candidus, optionallystrain Y21007-2, (products known as Bio-bac), (C1.78) Streptomyceslydicus, in particular strain WYCD108 (products known as ActinovateSP)or strain WYEC108 (products known as Actino-iron from NaturalIndustries), (C1.79) Streptomyces saraceticus, (C1.80) Streptomycesvenezuelae, (C1.81) Xenorhabdus nematophila, (C1.82) Agrobacteriumradiobacter, (C1.83) Bacillus mojavensis, especially strain CECT-7666,(C1.84) Pantoea agglomerans, optionally strain E325 (products known asBloomtime Biological FD Biopesticide), (C1.85) Streptomycescolombiensis, (C1.86) Streptomyces sp. WYE 20 (KCTC 0341BP) and WYE 324(KCTC 0342BP), (C1.87) Bacillus brevis (also known as Brevibacillusbrevis, product known as Brevisin), optionally strain SS86-3 or strainSS86-4 or strain SS86-5 or strain 2904, (C1.88) Erwinia carotovora (alsoknown as Pectobacterium carotovorum) carotovora (product known asBiokeeper), (C1.89) Xanthomonas campestris pv vesicatoria (product knownas Camprico), (C1.90) Pasteuria reniformis, optionally strain Pr3,(C1.91) Burkholderia spec strain A396 (Accession No. NRRL B-50319,product known as MBI-206 TGAI from Marrone Bio Innovations), (C1.92)Bacillus firmus CNCM I-1582, optionally the spores (cf. U.S. Pat. No.6,406,690, products known as Bionem, VOTIVO), (C1.93) Bacillus cereus(synonyms: Bacillus endorhythmos, Bacillus medusa), optionally inparticular spores of Bacillus cereus strain CNCM I-1562 (cf. U.S. Pat.No. 6,406,690), or strain BP01 (ATCC 55675, product known as Mepichlorfrom Arysta, US or Mepplus, Micro-Flo Company LLC, US), (C1.94) Bacillusamyloliquefaciens strain IN937a or strain FZB42 (DSM 231179, productknown as RhizoVital® from ABiTEP, DE), or strain B3, or strain D747,(products known as Bacstar® from Etec Crop Solutions, NZ, or DoubleNickel™ from Certis, US), (C1.95) Bacillus subtilis, optionally strainGB03 (Accession No. ATCC SD-1397, product known as Kodiak® from BayerCrop Science, DE) or strain QST713/AQ713 (Accession No. NRRL B-21661,products known as Serenade QST 713@, Serenade Soil and Serenade Max fromAgraQuest, US) or strain AQ 153 (ATCC accession No. 55614) or strainAQ743 (Accession No. NRRL B-21665) or strain DB 101, (products known asShelter from Dagutat Bio lab, ZA) or strain DB 102, (products known asArtemis from Dagutat Bio lab, ZA) or strain MBI 600, (products known asSubtilex from Becker Underwood, US) or strain QST30002/AQ30002(Accession No. NRRL B-50421, cf. WO 2012/087980) or strainQST30004/AQ30004 (Accession No. NRRL B-50455, cf. WO 2012/087980),(C1.96) Bacillus pumilus, optionally strain GB34 (Accession No. ATCC700814, products known as Yield Shield® from Bayer Crop Science, DE) orstrain QST2808 (Accession No. NRRL B-30087, products known as Sonata QST2808® from AgraQuest, US), or strain BU F-33 (product known as IntegralF-33 from Becker Underwood, US), or strain AQ717 (Accession No. NRRLB21662, (C1.97) Pasteuria sp., optionally strain SD-5832 and (C1.98)Pasteuria sp., optionally strain PTA-9643, (C1.98) Agrobacteriumradiobacter, optionally strain K84 (products known as Galltrol-A fromAgBioChem) or strain K1026 (products known as Nogall, Becker Underwood),(C1.99) Agrobacterium vitis, optionally the non-pathogenic strainVAR03-1, (C1.100) Azorhizobium caulinodans, optionally strain ZB-SK-5,(C1.101) Azospirillum amazonense, (C1.102) Azospirillum brasilense,(C1.103) Azospirillum halopraeference, (C1.104) Azospirillum irakense,(C1.105) Azospirillum lipoferum, (C1.106), Azotobacter chroococcum,optionally strain H 23 (CECT 4435), (C1.107) Azotobacter vinelandii,optionally strain ATCC 12837, (C1.108) Bacillus acidocaldarius, (C1.109)Bacillus acidoterrestris, (C1.110) Bacillus alcalophilus, (C1.111)Bacillus alvei, (C1.112) Bacillus aminoglucosidicus, (C1.113) Bacillusaminovorans, (C1.114) Bacillus amylolyticus (also known as Paenibacillusamylolyticus), (C1.115) Bacillus aneurinolyticus, (C1.116) Bacillussubtilis isolate B246, for example in form of the commercially availableproduct Avogreen from RE at UP), (C1.117) Bacillus tequilensis,optionally strain NII-094, (C1.118) Bacillus sp. strain AQ175 (ATCCAccession No. 55608), (C1.119) Bacillus sp. strain AQ177 (ATCC AccessionNo. 55609), (C1.120) Bacillus sp. strain AQ178 (ATCC Accession No.53522), (C1.121) Gluconacetobacter diazotrophicus, (C1.122)Herbaspirilum rubrisubalbicans, (C1.123) Herbaspirilum seropedicae,(C1.124) Lactobacillus sp. (products known as Lactoplant fromLactoPAFI), (C1.125) Lysobacter enzymogenes, optionally strain C3 (cf. JNematol. 2006 June; 38(2): 233-239), (C1.126) Rhodococcus globerulusstrain AQ719 (Accession No. NRRL B21663, from AgraQuest), (C1.127)Streptomyces sp. Strain NRRL B-30145 (from Agraquest), (C1.128)Streptomyces acidiscabies, optionally strain RL-110T, (product known asMBI-005EP from Marrone Bioinnovations), (C1.129) Streptomycesgoshikiensis, (C1.130) Streptomyces lavendulae, (C1.131) Streptomycesprasinus (cf. “Prasinons A and B: potent insecticides from Streptomycesprasinus” Applied microbiology 1973 November), (C1.132) Streptomycesrimosus; (C2) fungi or yeasts selected from the group consisting of:(C2.1) Ampelomyces quisqualis, optionally strain AQ 10 (product known asAQ 10®), (C2.2) Aureobasidium pullulans, optionally blastospores ofstrain DSM14940 or blastospores of strain DSM 14941 or mixtures thereof(product known as Blossom Protect®), (C2.3) Beauveria bassiana,optionally strain ATCC 74040 (products known as Naturalis®) or strainGHA (products known as Mycotrol, BotaniGard) or strain ATP02 (DSM 24665)or strain CG716 (product known as BoveMax), (C2.4) Candida oleophila,optionally strain O (products known as Nexy®) or strain I-182 (productsknown as ASPIRE®, Decco I-182), (C2.5) Coniothyrium minitans, optionallystrain CON/M/91-8 (DSM-9660) (products known as Contans®), (C2.6)Dilophosphora alopecuri (products known as Twist Fungus®), (C2.7)Gliocladium catenulatum, optionally strain J1446 (products known asPrestop®), (C2.8) Lecanicillium lecanii (formerly known as Verticilliumlecanii), optionally conidia of strain KV01 (products known as Mycotal®,Vertalec®, from Koppert/Arysta) or strain DAOM198499 or DAOM216596,(C2.9) Metarhizium anisopliae, optionally strain F52 (DSM 3884, ATCC90448, products known as BIO 1020, MET52) or var. acridum isolate IMI330189/ARSEF 7486 (products known as Green Muscle®) (C2.10)Metschnikovia fructicola, optionally the strain NRRL Y-30752 (productsknown as Shemer®), (C2.11) Microsphaeropsis ochracea (products known asMicrox®), (C2.12) Muscodor albus, optionally strain QST 20799 (productsknown as QRD300), (C2.13) Nomuraea rileyi, optionally strains SA86101,GU87401, SR86151, CG128 and VA9101, (C2.14) Paecilomyces lilacinus,optionally spores of P. lilacinus strain 251(AGAL 89/030550) (productsknown as BioAct®, cf. Crop Protection 2008, 27, 352-361), (C2.15)Paecilomyces fumosoroseus (also known as Isaria fumosorosae), optionallystrain apopka 97 (ATCC 20874) (products known as PFR-97TM 20% WDG,PreFeRal® WG,), (C2.16) Penicillium bilaii, optionally strain ATCC22348(products known as JumpStart®, PB-50, Provide), (C2.17) Pichia anomala,optionally strain WRL-076, (C2.18) Pseudozyma flocculosa, optionallystrain PF-A22 UL (products known as Sporodex® L), (C2.19) Pythiumoligandrum, optionally strain DV74 (products known as Polyversum) orstrain M1 (ATCC 38472), (C2.20) Trichoderma asperellum, optionallystrain ICC 012 (also known as Trichoderma harzianum ICC012, productsknown as Bioten®) or strain SKT-1 (products known as Triderma® orECO-HOPE®) or strain T34 (products known as T34 Biocontrol) or strainSF04 or strain TV1 (also known as Trichoderma viride TV1) or strain T11(also known as Trichoderma viride T25), (C2.21) Trichoderma harzianum,optionally T. harzianum T39 (products known as Trichodex®) or strainT-22 (products known as PLANTSHIELD®T-22G, Rootshield, TurfShield), orstrain TH 35 (products known as ROOT PRO®) or strain TSTh20/PTA-0317 orstrain 1295-22 (products known as Bio-Trek), (C2.22) Beauveriabrongniartii (products known as Beaupro), (C2.23) Aschersonia aleyrodes,(C2.24) Hirsutella thompsoni (products known as Mycohit), (C2.25)Lagenidium giganteum (products known as LAGINEX®), (C2.26) Myrotheciumverrucaria strain AARC-0255 (products known as DiTera™), (C2.27) Pandoradelphacis, (C2.28) Tsukamurella paurometabola, optionally strain C924(products known as HeberNem®), (C2.30) ARF 18 (Arkansas Fungus 18),(C2.31) Trichoderma atroviride optionally strain CNCM I-1237 (productsknown as Esquive® WP, Sentinel®, Tenet®) or strain NMI No. V08/002387 orstrain NMI No. V08/002389 or strain NMI No. V08/002390 or strain NMI No.V08/002388 (patent application US 2011/0009260) or strain ATCC 20476(IMI 206040) or strain T11 (IM1352941) or strain LC52 (products known asSentinel®, Agrimm Technologies, (products known as Esquive®) or strainNMI V08/002387, or strain NMI V08/002389 or strain SKT-1/FERM P-1651 orstrain SKT-2/FERM P-16511 or strain SKT-3/FERM P17021 (described inJP3691264) or strain L52 (product known as SENTINEL®), (C2.32) Glomusaggregatum, (C2.33) Glomus etunicatum, (C2.34) Glomus intraradices,(C2.35) Glomus mosseae, (C2.36) Glomus deserticola, (C2.37) Glomusclarum, (C2.38) Glomus brasilianum, (C2.39) Glomus monosporum, (C2.40)Gigaspora margarita, (C2.41) Rhizopogon villosullus, (C2.42) Rhizopogon.luteolus, (C2.43) Rhizopogon. amylopogon, (C2.44) Rhizopogon fulvigleba,(C2.45) Pisolithus tinctorius, (C2.46) Scleroderma cepa, (C2.47)Scleroderma citrinum, (C2.48) Suillus granulatus, (C2.49) Suilluspunctatapies, (C2.50) Laccaria laccata, (C2.51) Laccaria bicolor;(C2.52) Metarhizium flavoviride, (C2.53) Arthrobotrys dactyloides,(C2.54) Arthrobotrys oligospora, (C2.55) Arthrobotrys superba (C2.56)Aspergillus flavus strain NRRL 21882 (product known as Afla-Guard®, fromSyngenta) or strain AF36 (product known as AF36), (C2.57) Candidasaitoana, in particular strain NRRL Y-21022 (products known as BIOCURE®or BIOCOAT®), (C2.58) Chaetomium cupreum, (C2.59) Chaetomium globosum,(C2.60) Chondrostereum purpureum, in particular strain PFC2139, (C2.61)Cladosporium cladosporioides strain H39 (as described in EP2230918 A1),(C2.62) Conidiobolus obscurus, (C2.63) Cryptococcus albidus (productknown as Yield Plus®.), (C2.64) Cryptococcus flavescens, optionallystrain NRRL Y-50378 and strain NRRL Y-50379, (C2.65), Dactylariacandida, (C2.66) Entomophthora virulenta, (C2.67) Harposporiumanguillullae, (C2.68) Hirsutella minnesotensis, (C2.69) Hirsutellarhossiliensis, (C2.70) Meristacrum asterospermum, (C2.71) Microdochiumdimerum, optionally strain L13 (products known as ANTIBOT®, Agrauxine),(C2.72) Monacrosporium cionopagum, (C2.73) Monacrosporium psychrophilum,(C2.74) Monacrosporium drechsleri, (C2.75) Monacrosporium gephyropagum,(C2.76) Ophiostoma piliferum, optionally strain D97 (products known asSylvanex), (C2.77) Paecilomyces variotii, optionally strain Q-09(product known as Nemaquim), (C2.78) Pochonia chlamydosporia(=Vercillium chlamydosporiumi), (C2.79) Pseudozyma aphidis, (C2.80)Stagonospora heteroderae, (C2.81) Stagonospora phaseoli, (C2.82)Talaromyces flavus, in particular strain V117b (products known asPROTUS®), (C2.83) Trichoderma viride (also known as Trichoderma gamsii),optionally strain ICC 080 (products known as REMEDIER® WP, Bioderma®)and strain TV1 (products known as T. viride TV1, Agribiotec), (C2.84)Trichoderma harmatum, isolate 382 (C2.85) Trichoderma koningii, (C2.86)Trichoderma lignorum, (C2.87) Trichoderma polysporum, isolate IMI 206039(ATCC 20475), (C2.88) Trichoderma stromaticum, (C2.89) Trichodermavirens (also known as Gliocladium virens), in particular strain GL-21(products known as SOILGARD®) or strain G41 (products known as BW240 WPBiological Fungicide), (C2.90) Ulocladium oudemansii, optionally iparticular strain HRU3 (products known as BOTRY-ZEN®), (C2.91)Verticillium alboatrum in particular strain WCS850, (C2.92) Verticilliumchlamydosporium, (C2.93) Verticillium dahlia isolate WCS 850 (productsknown as Dutch Trig), (2.94) Zoophtora radicans, (2.95) Cylindrocarponheteronema, (C2.96) Exophiala jeanselmei, (C2.97) Exophilia pisciphila,(C2.98) Fusarium aspergilus, (C2.99) Fusarium oxysporum, optionally thenon pathogenic strain Fo47 (product FUSACLEAN) or the non pathogenicstrain 251/2RB (product known as BIOFOX®), (C2.100) Fusarium solani, forexample strain Fs-K (as described in patent application US20110059048),(C2.101) Gliocladium roseum, optionally in particular strain 321U,(C2.102) Mucor haemelis (products known as BIO-AVARD), (C2.103)Nematoctonus geogenius, (C2.104) Nematoctonus leiosporus, (C2.105)Phlebiopsis gigantea (products known as ROTSOP®), (C2.106) Trichodermaalbum (products known as Biozeid®), (C2.107) Trichoderma asperellum(products known as BIO-TAM™) and, (C2.108) Trichoderma gamsii (productsknown as BIO-TAM™) or optionally strain ICC080 (products known asBioderma), (C2.109) Hirsutella citriformis, (C2.110) Muscodor roseusstrain A3-5 (Accession No. NRRL 30548), (C2.111) Neocosmosporavasinfecta, (C2.112) Penicillium vermiculatum (products known asVermiculen®), (C2.113) Saccharomyces cerevisae, in particular strainCNCM No. I-3936, strain CNCM No. I-3937, strain CNCM No. I-3938, strainCNCM No. I-3939 (patent application US 2011/0301030), (C2.114)Sporothrix insectorum (products known as Sporothrix®), (C3) Protozoasselected from the group consisting of (C3.1) Nosema locustae, (C3.2)Thelohania, (C3.3) Vairimorpha; (C4) Viruses selected from the groupconsisting of (C4.1) Gypsy moth (Lymantria dispar) nuclear polyhedrosisvirus (NPV), (C4.2) Tussock moth (Lymantriidae) NPV, (C4.3) HeliothisNPV, (C4.4) Pine sawfly (Neodiprion) NPV, (C4.5) Codling moth (Cydiapomonella) granulosis virus (GV), (C4.6) Adoxophyes orana GV (productknown as Capex®), (C4.7) Helicoverpa armigera NPV (products known asVivus Max®, Vivus Gold®) or Gemstar®), (C4.8) Spodoptera exigua NPV,(C4.9) Spodoptera littoralis NPV, (C4.10) Spodoptera litura NPV, (C4.11)Neodiprion abietis NPV (product known as ABIETIV™), (C4.12) Neodiprionsertifer NPV (product known as Neocheck-S™), (C4.13) Agrotis segetum(turnip moth) nuclear polyhedrosis virus (NPV), (C4.14) Anticarsiagemmatalis (Woolly pyrol moth) mNPV (products known as Polygen), (C4.15)Autographa californica (Alfalfa Looper) mNPV (products known as VPN80from Agricola El Sol); (C5) entomopathogenic nematodes selected from thegroup consisting of (C5.1) Steinernema ssp. (=Neoaplectana spp.), (C5.2)Steinernema scapterisci, (C5.3) Steinernema feltiae (=Neoplectanacarpocapsae, products known as Nemasys®), (C5.4) Steinernema carpocapsae(products known as Biocontrol; Nematac® C), (C5.5) Heterorhabditis spp.,(C5.6) Heterorhabditis heliothidis, (C5.7) Hexamermis spp., (C5.8)Amphimermis spp., (C5.9) Mermis nigrescens, (C5.10) Agamermis decaudata,(C5.11) Maupasina weissi, (C5.12) Subulura spp., (C5.13) Seuratumcadarachense, (C5.14) Pterygodermatites spp., (C5.15) Abbreviatacaucasica, (C5.16) Spirura guianensis, (C5.17) Diplotriaena spp.,(C5.18) Tetrameres spp., (C5.19) Acuaria spp., (C5.20) Gongylonema spp.,(C5.21) Protrellatus spp., (C5.22) Hydromermis spp., (C5.23) Cameroniaspp., (C5.24) Physaloptera spp., (C5.25) Chitwoodiella ovofilamenta,(C5.26) Gynopoecilia pseudovipara, (C5.27) Parasitylenchus spp., (C5.28)Neoparasitylenchus rugulosi, (C5.29) Sulphuretylenchus elongatus,(C5.30) Sphaerulariopsis spp., (C5.31) Allantonema spp., (C5.32)Contortylenchus spp., (C5.33) Bovienema spp., (C5.34) Parasitaphelenchusspp., (C5.35) Parasitorhabditis spp., (C5.36) Phasmarhabditishermaphrodita, (C5.37) Romanomermis spp., (C5.38) Octomyomermis spp.,(C5.39) Strelkovimermis peterseni, (C5.40) Perutilimermis culicis,(C5.41) Culicimermis spp., (C5.42) Empidomermis spp., (C5.43)Gastromermis spp., (C5.44) Isomermis spp., (C5.45) Neomesomermis spp.,(C5.46) Limnomermis spp., (C5.47) Mesomermis spp., (C5.48) Xenorhabdusluminescence (entomopathogenic bacteria symbiotically associated withnematodes); (C5.49) Heterorhabditis bacteriophora (products known asB-Green, Nemasys® G), (C5.50) Heterorhabditis baujardi, (C5.51)Heterorhabditis indica (products known as Nematon), (C5.52)Heterorhabditis marelatus, (C5.53) Heterorhabditis megidis, (C5.54)Heterorhabditis zealandica, (C5.55) Phasmarhabditis hermaphrodita,(C5.56) Steinernema bibionis, (C5.57) Steinernema glaseri (productsknown as Biotopia), (C5.58) Steinernema kraussei (products known asLarvesure, Nemasys® L), (C5.59) Steinernema riobrave (products known asBiovector), (C5.60) Steinernema scapterisci (products known asNematacS), (C5.61) Steinernema scarabaei, (C5.62) Steinernema siamkayai,(C5.63) Beddingia (=Deladenus) siridicola, (C5.64) Filipjevimermisleipsandra, (C5.65) Steinernema thailandse products known as Nemanox®),(C6) Inoculants selected from the group consisting of (C6.1) Rhizobiumleguminosarum, in particular bv. viceae strain Z25 (Accession No. CECT4585), (C6.2) Rhizobium tropici, (C6.3) Rhizobium loti, (C6.4) Rhizobiumtrifolii, (C6.5) Rhizobium meliloti, (C6.6) Rhizobium fredii, (C6.7)Azorhizobium caulinodans, (C6.8) Pseudomonas, (C6.9) Azospirillum,(C6.10) Azotobacter, (C6.11) Streptomyces, (C6.12) Burkholdia, (C6.13)Agrobacterium, (C6.14) Endo Mycorhiza, (C6.15) Ecto Mycorhiza, (C6.16)Vesicular Arbuscular (VA) Mycorhiza, (C6.17) Bradyrhizobium; (C7)Botanicals (or: plant extracts) selected from the group consisting of(C7.1) Thymus oil, (C7.2) Azadirachtin (Neem), (C7.3) Pyrethrum, (C7.4)Cassia nigricans, (C7.5) Quassia amara, (C7.6) Rotenon, (C7.7) Garlic,(C7.8) Quillaja, (C7.9) Sabadilla, in particular Veratrin, (C7.10)Ryania, optionally Ryanodine, (C7.11) Viscum album (mistel), (C7.12)mugwort or common tansy (Tanacetum vulgare), (C7.13) Artemisiaabsinthium, (C7.14) Urtica dioica, (C7.15) Symphytum officinale, (C7.16)Tropaeulum majus, (C7.17) Quercus (C7.18) mustard flour, (C7.19)Chenopodium anthelminticum, (C7.20) Dryopteris filix-mas, (C7.21) barkof Chinese bittersweet (Celastrus orbiculatus), (C7.22) Equisetumarvense, (C7.23) bark of Celastus angulatus, (C7.24) Laminarin (BrownAlgae), (C7.25) Alginic acid (Brown Algae), (C7.26) Chitin/Chitinosan.(C7.27) Chenopodium quinoa (product known as HeadsUp), (C7.28) Melaleucaalternifolia (products known as Timorex Gold®), (C7.29) Sesame oil(product known as Dragongfire-CCP™) and (C7.30) natural extracts orsimulated blend of Chenopodium ambrosioides (products known as Requiem).(C8) Products produced by microorganisms including proteins or secondarymetabolites selected from the group consisting of (C8.1) Harpin(produced by Erwinia amylovora, products known as Harp-N-Tek™,Messenger®, Employ™ ProAct™).
 5. Composition comprising an activecompound combination according to claim 1 and further comprising atleast one of an auxiliaries, solvents, carriers, surfactants and/orextenders.
 6. Method for controlling insects, nematodes orphytopathogens comprising applying an active compound combinationaccording to claim 1 to seed, a plant, to fruit of a plant and/or tosoil on which a plant grows and/or is supposed to grow.
 7. Methodaccording to claim 6, wherein the plant, the fruit of the plant and/orthe soil on which the plant grows and/or is intended to grow is treated.8. Method according to claim 6, wherein, in treatment of leaves, from0.01 to 10 000 g/ha is employed and in the treatment of seed, from 2 to200 g per 100 kg of seed is employed.
 9. Use of An active compoundcombination according to claim 1 capable of being used for controllingone or more of insects, nematodes and/or phytopathogens in cropprotection.
 10. An active compound combination according to claim 1capable of being used for treating seed, seed of a transgenic plantand/or a transgenic plant.
 11. Seed treated with an active compoundcombination according to claim
 1. 12. Method of treating a plantcomprising applying an active compound combination according to claim 1for improvement of plant properties comprising one or more of bettergrowth or increased harvest yields or a better developed root system ora larger leaf area or greener leaves or stronger shoots.